“…IL-3 is known to mediate a variety of cellular activities in Ba/F3 cells through Jak/STAT, Ras/Raf/ MAPK, and PI3K/Akt signaling pathways. Furthermore, 14-3-3/␥ isoforms through dimerization by interaction with Sirt2 and down-regulation of p53 have been tied to higher survival function (53,54). We have observed the up-regulation of PI3K, Akt, MEK1, p-ERK, p-p38, p-JNK, and PKC as a consequence of ectopic expression of 14-3-3␥, revealing its importance in activating signaling cascades that promote cell survival and proliferation; in contrast, the up-regulation of Bad and Bax were seen with the ablation of 14-3-3␥ both in vivo and in vitro (19,55).…”