Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model

Ozawa, Hideto; Miyagawa, Shigeru; Fukushima, Satsuki; Itoh, Eriko; Harada, Akira; Saito, Atsuhiro; Ueno, Takayoshi; Toda, Köichi; Kuratani, Toru; Sawa, Yoshiki

doi:10.1016/j.athoracsur.2016.02.093

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…Recently, it has been shown that Sirt1 plays a vital role in higher-order brain dysfunctions such as drug addiction [ 20 ], endocrine regulation [ 18 , 21 ], and synaptic plasticity [ 22 , 23 ]. Furthermore, there are pieces of evidence suggesting that Sirt1 plays a critical role in cardiovascular diseases [ 24 ], metabolic and health span [ 25 , 26 ], neurodegenerative diseases [ 27 , 28 ], cancer [ 29 ], and optic neuritis [ 30 ].…”

Section: Sirt1mentioning

confidence: 99%

Role and Possible Mechanisms of Sirt1 in Depression

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

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Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD+ and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target. In this short review article, we attempt to present an up-to-date knowledge of depression and Sirt1 of the sirtuin family, describe the different effects of Sirt1 on depression, and further discuss possible mechanisms of Sirt1 including glial activation, neurogenesis, circadian control, and potential signaling molecules. Thus, it will open a new avenue for clinical treatment of depression.

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Section: Sirt1mentioning

confidence: 99%

Role and Possible Mechanisms of Sirt1 in Depression

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Transplantation from Sirt1-KO stem cells caused less functional improvement compared to the other groups. Moreover, in vitro study showed less proliferation potential and more cytokine secretion from Sirt1-KO cells compared to the wild type [60]. Taken together, either intrinsic Sirt1 expression by stem cells or Sirt1 overactivation induction in stem cells could be considered as a therapeutic option for treating certain diseases as well as improving stem cell transplantation (Table 2).…”

Section: Sirtuin 1 and Stem Cell Transplantation In 2012 Leko Et Almentioning

confidence: 99%

“…Sirt1−/− bone marrow TX ⟶ normal output (55) Sirt1−/− bone marrow TX ⟶ stem cells aberrant expansion, increased DNA damage, p53 overactivation, and genomic instability (56) Intrabone marrow-bone marrow TX ⟶ amelioration of SAMP10 and mice nonalcoholic fatty liver disease (57, 58) SRT-1720-pretreated-mesenchymal stem cells infusion to myocardial infarction model ⟶ left ventricular ejection fraction↑, angiogenesis↑, fibrosis↓(59) Sirt1-KO skeletal stem cell TX infusion to myocardial infarction model ⟶ functional improvement↓, proliferation rate↓, cytokine secretion↑ (60) Liver transplantation…”

Section: Stem Cell Transplantationmentioning

confidence: 99%

“…Liver preservation in TMZ ⟶ Sirt1 activation ⟶ p53 and FoxO expression↓, ALT and GDH↓, improved graft survival (61) Losartan administration before liver TX ⟶ Sirt1↑, FoxO1↓, ALT and AST↓, caspase 12 and cleaved caspase 3↓ (62) particular, liver transplant recipients may profit from antiinflammatory and tissue preserving properties of Sirt1 if its natural or pharmacological activators are included in their immunosuppressive drugs. Despite positive results obtained from the injection of Sirt1+ mesenchymal stem cells for tissue regeneration in animal models [59,60] there are almost no solid findings about its efficacy in human patients. e potential of Sirt1 in tissue repair and maintenance suggest it as a candidate for manipulating mesenchymal stem cells and transferring them into the damaged tissue particularly in heart stroke.…”

Section: Stem Cell Transplantationmentioning

confidence: 99%

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Sirtuin 1: A Dilemma in Transplantation

Assadiasl

Mooney

Mohebbi

et al. 2020

Journal of Transplantation

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Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations. In view of the anti-inflammatory properties of sirtuin 1 along with its protective role in ischemia reperfusion injury, it might be considered as contributing to the promotion of transplantation outcome. However, the potential ability of sirtuin 1 to induce malignancies raises some concerns about its overexpression in clinic. Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation. The identification of sirtuin 1 natural and synthetic activators leads to the proposal of sirtuin 1 as an eligible target for clinical interventions in transplantation. All positive and negative consequences of sirtuin 1 overactivation/overexpression in the allograft should therefore be studied thoroughly. Herein, we summarize previous findings concerning direct and indirect influences of sirtuin 1 manipulation on transplantation.

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“…The results are expressed as the average diameter of myocytes randomly selected from 10 fields of each ventricle. 15) In addition, the paraffin sections were labeled for anti-CD31 antibodies (Abcam, Cambridge, UK) and visualized using LSABTM kits (Dako, Glostrup, Denmark). Vessel density was quantified as the number of CD 31-positive vessels per millimeter squared.…”

Section: Definition Of Myocardial Areasmentioning

confidence: 99%

Microvascular Dysfunction Related to Progressive Left Ventricular Remodeling due to Chronic Occlusion of the Left Anterior Descending Artery in an Adult Porcine Heart

et al. 2019

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Occlusion of a major coronary artery induces myocardial infarction (MI), leading to left ventricle (LV) remodeling due to progressive microvasculature dysfunction. Irreversible impairment in microvascular function has been suggested to extend from the infarcted region into the infarct-border or remote regions, depending on the time to revascularization. Our aim was to determine whether the occlusion of a major coronary artery induces microvascular dysfunction in the adjacent area perfused by intact coronary arteries using a porcine model for chronic total occlusion of the left anterior descending artery (LAD). MI was induced via an ameroid constrictor ring around the LAD in adult Göttingen pigs (Sus scrofa domesticus, n = 5). Age-matched normal pigs were treated as controls (n = 3). Cardiac magnetic resonance showed reduced systolic regional wall motion in the left circumflex (LCx) and right coronary artery (RCA) territories, with a progressively worsening motion in the infarction-adjacent area over an eight-week period. On 13 N-ammonia positron emission tomography (PET), myocardial blood flow (MBF) during hyperemia was significantly greater in the LCx and RCA territories (particularly in the infarction-adjacent area) compared to that in the LAD territory at four weeks after infarct induction. Subsequently, the flow significantly decreased, approaching that in the LAD territory at eight weeks after infarct induction. Fluoroscopy-guided pressure-wire studies showed significantly higher microvascular resistance in the LCx area at eight weeks compared to that in controls. Electron microscopy showed endothelium swelling and microvasculature disruption in areas adjacent to the LCx and RCA territories. Anterior MI caused coronary microvascular dysfunction in the adjacent area, associated with a reduced MBF and regional wall motion.

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Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model

Cited by 8 publications

References 21 publications

Role and Possible Mechanisms of Sirt1 in Depression

Role and Possible Mechanisms of Sirt1 in Depression

Sirtuin 1: A Dilemma in Transplantation

Microvascular Dysfunction Related to Progressive Left Ventricular Remodeling due to Chronic Occlusion of the Left Anterior Descending Artery in an Adult Porcine Heart

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