Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models

Ranadive, Niraja; Arora, Devinder; Nampoothiri, Madhavan; Mudgal, Jayesh

doi:10.1016/j.brainresbull.2021.03.016

Cited by 3 publications

(3 citation statements)

References 67 publications

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“…Sirtuins (SIRTs) are ubiquitous regulators of cell activities that are class III histone deacetylases and have been shown to have neuroprotective properties in a variety of neurodegenerative disorders (Liu et al 2021;Ranadive et al 2021). In PVN, SIRT1 stimulates the HPA axis and basal glucocorticoid (GC) levels by increasing CRH production via an increase in prohormone convertase 2 (PC2) biosynthesis, which is required for the maturation of CRH from pro-CRH (Toorie et al 2016;Yamamoto and Takahashi 2018).…”

Section: Sirtuins and Ptsdmentioning

confidence: 99%

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Govindula

Ranadive

Nampoothiri

et al. 2023

J Neuroimmune Pharmacol

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Post-traumatic stress disorder (PTSD) is a chronic incapacitating condition with recurrent experience of trauma-related memories, negative mood, altered cognition, and hypervigilance. Agglomeration of preclinical and clinical evidence in recent years specified that alterations in neural networks favor certain characteristics of PTSD. Besides the disruption of hypothalamus-pituitary-axis (HPA) axis, intensified immune status with elevated pro-inflammatory cytokines and arachidonic metabolites of COX-2 such as PGE2 creates a putative scenario in worsening the neurobehavioral facet of PTSD. This review aims to link the Diagnostic and Statistical Manual of mental disorders (DSM-V) symptomology to major neural mechanisms that are supposed to underpin the transition from acute stress reactions to the development of PTSD. Also, to demonstrate how these intertwined processes can be applied to probable early intervention strategies followed by a description of the evidence supporting the proposed mechanisms. Hence in this review, several neural network mechanisms were postulated concerning the HPA axis, COX-2, PGE2, NLRP3, and sirtuins to unravel possible complex neuroinflammatory mechanisms that are obscured in PTSD condition.

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Section: Sirtuins and Ptsdmentioning

confidence: 99%

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Govindula

Ranadive

Nampoothiri

et al. 2023

J Neuroimmune Pharmacol

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“…Sirtuins, including SIRT1, are NAD+-dependent protein deacetylases, and have been shown to exhibit neuroprotective activities in animal models through reduction of neuroinflammation mediated by the NLRP3 inflammasome and cytokine/NF-κB (Ranadive et al, 2021). Whilst NAM exerts feedback inhibition to the sirtuin reactions, once administered to cells, NAM is converted to NAD+, resulting in a temporary initial inhibition of SIRT1, followed by an increase in the activity (Hwang and Song, 2017).…”

Section: Vitamin B3 (Nicotinamide)mentioning

confidence: 99%

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Reichelt¹,

Dunkley²

2022

Preprint

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Concussion, sometimes called a mild traumatic brain injury (mTBI), is an acquired brain injury resulting in alterations to brain function underpinned by a sequence of neuropathological and neurometabolic events that can result in excitotoxicity, oxidative stress, oedema, neuroinflammation and cell death. To date, pharmaceutical therapies have had limited success in treating TBI, presenting considerable interest in nutritional therapies in the form of dietary supplementation to alleviate the deleterious pathological sequelae following neurotrauma. Many nutritional supplements have low toxicity, few drug interactions, and are already approved for human use making them attractive potential therapies following a concussion. In the setting of brain injury models, a considerable body of preclinical evidence has accumulated supporting the use of nutritional supplements including essential fatty acids, vitamins, minerals, amino acids, polyphenols, bioflavonoids and other bioactive compounds to facilitate aspects of functional recovery. Here, we review studies presenting diet supplements as therapeutic strategies as potential treatments for mTBI or to augment neurological resistance against mTBI in experimental models, as well as emerging therapeutic targets including the gut microbiome, and psychedelic and non-psychedelic compounds derived from fungi.

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“…In addition, the SIRT2 inhibitor AK-7 improves the outcome of brain ischemia independent of p38 activation in mice [ 100 ]. On the contrary, SIRT2 inhibition was reported to exacerbate traumatic brain injury [ 101 , 102 ]. AK-7 administration in mice treated with experimental traumatic brain injury increases the volume of brain edema lesion, neuroinflammation, and blood-brain barrier disruption via both increased K310 acetylation and nuclear translocation of NF-kappaB p65.…”

Section: Sirt2 Mirnas Hypoxia Oxidative Stress and Neurodegenerative Diseasesmentioning

confidence: 99%

Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA–SIRT2 Axis and Its Relationship with Aging-Related Diseases

Kaitsuka

Matsushita

2021

Cells

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The sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylase and ADP-ribosyl transferases plays key roles in aging, metabolism, stress response, and aging-related diseases. SIRT2 is a unique sirtuin that is expressed in the cytosol and is abundant in neuronal cells. Various microRNAs were recently reported to regulate SIRT2 expression via its 3′-untranslated region (UTR), and single nucleotide polymorphisms in the miRNA-binding sites of SIRT2 3′-UTR were identified in patients with neurodegenerative diseases. The present review highlights recent studies into SIRT2-mediated regulation of the stress response, posttranscriptional regulation of SIRT2 by microRNAs, and the implications of the SIRT2–miRNA axis in aging-related diseases.

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Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models

Cited by 3 publications

References 67 publications

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

Nutrition and neutraceutical interventions as therapeutic strategies to aid recovery from mild traumatic brain injuries

Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA–SIRT2 Axis and Its Relationship with Aging-Related Diseases

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