Sistemik İsotretinoin Tedavisi Alan Akne Vulgaris Hastalarında Nötrofil- Lenfosit Oranı ve C-Reaktif Protein Düzeyleri

Abstract

Introduction: Inflammatory mediators have importance in acne vulgaris pathogenesis. Which mediators cause lesions or increase with which variants is not clear. Neutrophil-lymphocyte ratio and C-reactive protein are the inflammatory indicators that used for follow up of inflammatory diseases. There are various studies state that neutrophil-lymphocyte ratio and C-reactive protein levels are important for systemic isotretinoin treatment or not. Evaluation of changes in neutrophil-lymphocyte ratio and C-reactive protein levels with systemic isotretinoin treatment is the aim of this study. Material andMethod: Acne vulgaris patients who are treated with systemic isotretinoin and healthy control subjects between January 2006 and December 2016 in Konya Training and Research Hospital Dermatology outpatient clinic are included to study. Neutrophillymphocyte ratio and C-reactive protein levels compared in each group at the beginning of treatment and at the 3rd month.Results: 50 patients (28 of women and 22 of men) who are treated with systemic isotretinoin for acne vulgaris and 50 healthy control patients (21 of women and 29 of men) included to study. Mean age of treatment group was 21 (19-23) and control group was 29,5. Neutrophil-lymphocyte ratio are not found statistically significiant in patients and control group at the begining and middle of the treatment (1,84,[3,36-0,51] -1,62,[4,07-0,68], p:0,107), C-reactive protein levels show a statistically significiant decrease in patient group with treatment (p<0,028). Conclusion:Systemic isotretinoin treatment may affect neutrophillymphocyte ratio and C-reactive protein levels in patients. Further studies are needed to clarify this relation.

Effect of Isotretinoin Treatment on the Inflammatory Markers in Patients with Acne Vulgaris: A Case-Control Study

“…In a study, patients using oral isotretinoin showed a significant decrease with treatment. 33 In another study, there was no statistical difference in CRP values after 4 months of oral isotretinoin treatment. 34 However, there was a study showing a significant increase in CRP levels with 6 months of oral isotretinoin treatment.…”