Site, histological type, and thickness of primary cutaneous malignant melanoma in western Netherlands since 1980

Abstract

An increasing incidence of cutaneous malignant melanoma had been observed in the Netherlands. Therefore, between 1989 and 1992 a preventive skin cancer campaign was organized in part of western Netherlands. The effect of this screening campaign has yet to be evaluated by investigating the distribution of all in situ and invasive primary cutaneous melanoma according to anatomical subsite, tumour thickness, and histological type in a population-based study during 1980-92. A total number of 2236 (1361 female; 875 male) invasive and 580 (395 female; 185 male) in situ melanomas were diagnosed. The median age of patients with thin lesions was 46 years, intermediate lesions 54 years, and thick lesions 65 years, which may be indicative of slow tumour progression. The median thickness of the invasive lesions was 0.9 mm for women and 1.1 mm for men and the invasive to in situ ratio was 3.4 for female and 4.7 for male subjects, suggesting a reasonable awareness of melanoma in this population. The relative tumour density (RTD) was remarkably high for melanomas in the head/neck area for both sexes and invasive melanoma on the male trunk and the lower legs of females. The low RTD of invasive melanomas on the lower limbs of men and the high density in the head/neck area for both sexes are remarkable and support the aetiological role of ultraviolet exposure. It is concluded that our findings are in many ways similar to those of other descriptive studies.

Mortality from cutaneous melanoma: evidence for contrasting trends between populations

“…Given the importance of sun exposure during childhood to CMM in adult life (Autier and Doré, 1998), the continuously increasing CMM mortality observed among older people could be the consequence of heavy sun exposure when they were young 2. The decreasing thickness of CMM, reported in several countries, has been more pronounced in younger people (Van der Spek-Keijser et al, 1997;Bucchi et al, 1992) 3. The improvement in survival from CMM does not seem to be entirely attributable to earlier stage at diagnosis or to better medical management (Masbach et al, 1994).…”

Clinicopathological Analysis of Patients with Malign Melanoma

“…Van der Sperk Kreiger e arkadaşlar n n 8500 serilik çal şmas nda ortalama yaş 46 bulunmuştur (4). Uehera e arkadaşlar n n 103 hastal k çal şmas nda ortalama yaş 55 iken Kandolf-Sekulo ić e arkadaşlar n n 266 hastal k çal şmas nda 57 olarak saptanm şt r(5,6).…”

“…3 okuz ylül Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. 4 zmir Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. ÖZET GİRİŞ ve AMAÇ: u çal şmada Malign Melanom tan l hastalar n Klinikopatolojik özelliklerini incelemeyi amaçlad k. YÖNTEM ve GEREÇLER: u çal şmada okuz ylül Üni ersitesi Hastanesi T bbi Onkoloji bölümünde 1991-2011 Y llar aras nda takip edilen malign melanom tan l 166 hasta retrospektif olarak değerlendirilmiştir.…”

Bronzeamento e risco de melanoma cutâneo: revisão da literatura

“…The predominant anatomical area varies according to age: the disease occurs in areas less exposed to the sun (back, arms, shoulders, legs and thighs) in younger individuals, and in more exposed areas (head, neck) in older individuals. 34,89 The nodular subtype is the second most common amongst Caucasians, accounting for 10-12% of all diagnosed melanomas. 85 As with the superficial spreading melanoma, its anatomical distribution varies with age.…”

“…The first subtype accounts for 5% of melanomas in Caucasians, and is more frequently diagnosed in women, subjects older than 60 years, and in anatomical areas more intensely exposed to the sun. 34,89 The most common subtype among lightskinned individuals is the superficial spreading melanoma, which accounts for 70% of all diagnosed melanomas. The predominant anatomical area varies according to age: the disease occurs in areas less exposed to the sun (back, arms, shoulders, legs and thighs) in younger individuals, and in more exposed areas (head, neck) in older individuals.…”