Site of subcutaneous desferrioxamine injection is the initial site of post-transfusion urticaria in multi-transfused ββ-thalassaemia major patients

Daar, Shahina; Ghosh, Kanjaksha; Nirmala, V

doi:10.1046/j.1365-2257.2000.00258-1.x

Cited by 2 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concomitant diseases and additional medications were evenly distributed between cases and controls and could not be alleged to be primarily responsible for the elevated ferritin levels (table 1). Regarding the urticaria cases, deferoxamine has been shown to sensitize mast cells around the site of injection, causing a local histamine release [32], and it has been implicated as an allergen in urticarial reactions [33]. However, in the 2 cases with urticaria that were on deferoxamine, we could not implicate this drug in their pathogenesis as both cases subsided without change in the chelation treatment.…”

Section: Discussionmentioning

confidence: 52%

Higher Serum Ferritin Levels Correlate with an Increased Risk of Cutaneous Morbidity in Adult Patients with β-Thalassemia: A Single-Center Retrospective Study

Skandalis

Vlachos²,

Pliakou³

et al. 2015

Acta Haematol

View full text Add to dashboard Cite

Disturbed iron homeostasis characterizes β-thalassemia and increases its morbidity. Our aim was to retrospectively associate β-thalassemia disease characteristics with treatment-requiring skin conditions. The files of adult β-thalassemia (including sickle β-thalassemia) patients were screened over a 10-year period for treatment-requiring skin disease episodes and their correlation with hematologic diagnoses and epidemiological and serological characteristics. Seventy-eight patients were identified, and 7 (9%) developed at least one relevant episode including cutaneous small-vessel vasculitis (CSVV), urticaria, and leg ulcers. Average ferritin serum level correlated significantly with development of a dermatosis (2,034 ± 799 μg/l in cases vs. 920 ± 907 μg/l in the overall population; p = 0.001, ANOVA). This difference relied exclusively on the high ferritin levels observed in patients with ‘generalized' dermatoses (urticaria and CSVV: 3,860 ± 1,220 μg/l) as opposed to values within the normal range in the case of ‘localized' ones (leg ulcers: 662 ± 167 μg/l). The employed iron chelation treatment influenced ferritin levels (p = 0.002, Kruskal-Wallis test) since chelation with a single agent seems to increase the risk of a skin disease (p = 0.013, likelihood ratio method). Conclusively, serum ferritin can be evaluated as risk factor for generalized dermatoses, but not for leg ulcers, in patients with the β-thalassemia genotype. This risk can be efficiently controlled with adequate chelation.

show abstract

Section: Discussionmentioning

confidence: 52%

Higher Serum Ferritin Levels Correlate with an Increased Risk of Cutaneous Morbidity in Adult Patients with β-Thalassemia: A Single-Center Retrospective Study

Skandalis

Vlachos²,

Pliakou³

et al. 2015

Acta Haematol

View full text Add to dashboard Cite

show abstract

Automatic analysis of normal bone marrow blood cells using the XE‐2100 automated hematology analyzer

Shibata

Yamane

Yamamura

et al. 2003

Clinical Laboratory Analysis

View full text Add to dashboard Cite

The bone marrow aspiration test conventionally has been performed by visual methods, using a light microscope, because automatic blood cell analyzers cannot adequately capture erythroblasts and immature granulocytes (IGs) (Tatsumi et al.: Osaka City Med J 1988;34:135-146 by the microscopic method and with the XE2100, and compared the results. A good correlation was found in the nucleated red blood cell (NRBC), white blood cell (WBC), and total nucleated cell (TNC) counts; the myeloid/erythroid ratio (M/E ratio); neutrophils, lymphocytes, eosinophils, and IGs in the immature myeloid information (IMI) channel; and the total cell count. These items can all be analyzed in about 54 sec with the XE2100, which is faster than with the microscopic method. Therefore, analysis of bone marrow aspiration specimens with this apparatus appears to be very useful for clinical screening as well as laboratory testing.

show abstract

Site of subcutaneous desferrioxamine injection is the initial site of post-transfusion urticaria in multi-transfused ββ-thalassaemia major patients

Cited by 2 publications

References 5 publications

Higher Serum Ferritin Levels Correlate with an Increased Risk of Cutaneous Morbidity in Adult Patients with β-Thalassemia: A Single-Center Retrospective Study

Higher Serum Ferritin Levels Correlate with an Increased Risk of Cutaneous Morbidity in Adult Patients with β-Thalassemia: A Single-Center Retrospective Study

Automatic analysis of normal bone marrow blood cells using the XE‐2100 automated hematology analyzer

Contact Info

Product

Resources

About