Site-Specific Deterioration of Trabecular Bone Architecture in Men and Women With Advancing Age

Abstract

ABSTRACT:We tested the hypothesis that the age dependence of trabecular bone microstructure differs between men and women and is specific to skeletal site. Furthermore, we aimed to investigate the microstructural pattern of bone loss in aging. Microstructural properties of trabecular bone were measured in vitro in 75 men and 75 age-matched women (age, 52-99 yr) using CT. Trabecular bone samples were scanned at a 26-m isotropic resolution at seven anatomical sites (i.e., distal radius, T 10 and L 2 vertebrae, iliac crest, femoral neck and trochanter, and calcaneus). DXA measurements were obtained at the distal radius and proximal femur and QCT was used at T 12 . No significant decrease in bone density or structure with age was found in men using CT, DXA, or QCT at any of the anatomical sites. In women, a significant age-dependent decrease in BV/TV was observed at most sites, which was strongest at the iliac crest and weakest at the distal radius. At most sites, the reduction in BV/TV was associated with an increase in structure model index, decrease in Tb.N, and an increase in Tb.Sp. Only in the calcaneus was it associated with a significant decrease in Tb.Th. In conclusion, a significant, site-specific correlation of trabecular bone microstructure with age was found in women but not in men of advanced age. The microstructural basis by which a loss of BV/TV occurs with age can vary between anatomical sites.

Interrelationships between Tooth Properties and Biochemical Bone Turnover Markers Investigated on Six-Month-Old Pig Model

“…However, these negative correlations with age were site-specific and obtained in differentiated localization in the skeleton for each diagnostic method. The fact that the observed interrelationships were stated only in postmenopausal women is also noteworthy [18].…”

Bone microarchitecture at muscle attachment sites: The relationship between macroscopic scores of entheses and their cortical and trabecular microstructural design

“…In this context, bone microarchitecture may better reflect bone loading history (Hert, 1994a;Skedros and Baucom, 2007;-Durić et al, 2012), and such a link was evaluated at various skeletal sites experiencing different loading conditions (Lochmuller et al, 2008;Djuric et al, 2010;Turunen et al, 2013). However, the microarchitecture of bony parts of entheses has been widely neglected, and the relationship between the macroscopic and microscopic appearance at the sites of muscle attachments has not been established.…”

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

“…Cancellous bone specimen of 8 mm × 8 mm × 8 mm cube was prepared from the central part of femoral neck for quantitative micro-CT examination. Alterations of the femoral neck cancellous bone with advancing age include a decline in BV/TV and Tb.N, and an increase in Tb.Sp [49,51,52] . BV/TV decreases by around 20% from 60 to 90 years of age (Figure 4).…”

“…Consequently, in addition to age, gender is also an important factor to influence cortical porosity. With advancing age, especially in females several intracortical pores coalesce into a giant pores larger than 385 m [46,52,55] . The giant intracortical pore formation might have a pivotal function in the process of local cortical bone loss during aging.…”