Six-coordinate oxo-vanadium(V) dimer complex with methoxy bridging: Synthesis, crystal structure, biological activity and molecular docking

Heidari, Farideh; Fatemi, S. Jamil. A.; Ebrahimipour, S. Yousef; Ebrahimnejad, Hadi; Castro, Jesús; Dušek, Michal; Eigner, Václav

doi:10.1016/j.inoche.2016.11.015

Cited by 33 publications

(10 citation statements)

References 20 publications

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“…Finally, the turbidity of the wells was measured using a micro plate reader device. Growth of the microorganisms was followed by monitoring the absorbance at 620 nm after 24 h until the stationary phase was reached …”

Section: Methodsmentioning

confidence: 99%

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Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex

Ebrahimipour

Khosravan

White

et al. 2018

Applied Organom Chemis

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We synthesized a tridentate Schiff base ligand, 6-(((2-hydroxyphenyl)amino) methylene)-2-methoxycyclohexa-2,4-dienone [H 2 L], as well as its Mo(VI) complex [MoO 2 (L)(DMSO)], and then characterized them completely using elemental analysis, FT-IR, UV-Vis and 1 HNMR spectroscopy techniques. Xray single crystal diffraction method was used for the determination of the structure of the synthesized ligand and complex. All other spectroscopic techniques performed, confirmed that [MoO 2 (L)(DMSO)]had an octahedral geometry around the Mo(VI) central ion coordinated by the donor atoms of the deprotonated ligand, two oxido groups and one oxygen atom of DMSO molecule. Hybrid functional B3LYP with DGDZVP as basis set was applied for DFT calculations of the compounds in their ground state. The MEP, Mulliken, HOMO-LUMO energy gap and thermodynamic properties of the compounds were also theoretically predicted. In-vitro antimicrobial studies on the synthesized compounds indicated the great antibacterial activities of the Mo(VI) complex against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus bacteria.

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Section: Methodsmentioning

confidence: 99%

“…So, inactivation of this enzyme is lethal for the microorganism . This inactivation and subsequent antimicrobial activity can be studied theoretically using molecular docking …”

Section: Introductionmentioning

confidence: 99%

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex

Ebrahimipour

Khosravan

White

et al. 2018

Applied Organom Chemis

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“…Plates were incubated at specific conditions according to the microbe under assay (37 °C).In the final phase, we read immediately the turbidity of the wells using the micro plate reader device. Then the absorbance read at 620 nm wavelength, until the growth of bacteria reached the stationary phase after 24 hours …”

Section: Methodsmentioning

confidence: 99%

A mixed‐ligand quinazoline‐based Ni(II) Schiff base complex: Synthesis, characterization, crystal structure, antimicrobial investigation and catalytic activity for the synthesis of 2H–indazolo[2,1‐b]phthalazine‐triones

Nejad

Khosravan

Ebrahimipour

et al. 2017

Applied Organom Chemis

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A tridentate Schiff base ligand, (E)-3-((2-hydroxy-3-methoxybenzylidene)amino)-2-methylquinazolin-4(3H)-one [HL], and its mixed-ligand Ni(II) complex [Ni(L)(imi)], were synthesized and fully characterized using elemental analysis, FT-IR, UV-Vis and 1 HNMR spectroscopy techniques. The structure of the synthesized ligand and complex was determined with single crystal X-ray diffraction method. In the complex, a square planner geometry was observed around the Ni(II) central atom coordinated with the donor atoms of the Schiff base ligand and one nitrogen of imidazole group. In addition, the catalytic activity of the complex on the three-component condensation of hydrazine hydrate with phthalic anhydride and dimedone to obtain 2H-indazolo[2,1-b]phthalazine-triones was investigated. Furthermore, in-vitro antimicrobial studies were performed that indicated the great antibacterial activities of the Ni(II) complex against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus bacteria.

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“…It appears that vanadium IV has lower side effects than platinum metal ions (Leon et al 2017a ), hence, recent investigations are focused on the IV complexes to find a suitable drug with the lowest side effects on normal non-cancerous cells. Vanadium compounds as a new class of non-platinum metallodrugs have attracted much attention and large efforts have been made to discover new molecular targets of these compounds (Leon et al 2017a ; León et al 2016 ; Sciortino et al 2018 ; Ebrahimipour et al 2015 ; Abbasi et al 2017 ; Hong et al 2017 ; Schmidt et al 2017 ; Sheikhshoaie et al 2016 ; Ebrahimipour et al 2016 ; Nair et al 2016 ; Takjoo et al 2013 ; Takjoo et al 2017 ; Heidari et al 2017 ; Zabin and Abdelbaset 2016 ; Mohamadi et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells

et al. 2018

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Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol ([IV(L)] complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48 h using MTT assay to find IC50 concentration of vanadium m, [IV(L)] complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, [IV(L)] complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, [IV(L)] complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells.

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Six-coordinate oxo-vanadium(V) dimer complex with methoxy bridging: Synthesis, crystal structure, biological activity and molecular docking

Cited by 33 publications

References 20 publications

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex

A mixed‐ligand quinazoline‐based Ni(II) Schiff base complex: Synthesis, characterization, crystal structure, antimicrobial investigation and catalytic activity for the synthesis of 2H–indazolo[2,1‐b]phthalazine‐triones

Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells

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Six-coordinate oxo-vanadium(V) dimer complex with methoxy bridging: Synthesis, crystal structure, biological activity and molecular docking

Cited by 33 publications

References 20 publications

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO2 complex

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO2 complex

A mixed‐ligand quinazoline‐based Ni(II) Schiff base complex: Synthesis, characterization, crystal structure, antimicrobial investigation and catalytic activity for the synthesis of 2H–indazolo[2,1‐b]phthalazine‐triones

Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells

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Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex

Preparation, crystal structure, spectroscopic studies, DFT calculations, antibacterial activities and molecular docking of a tridentate Schiff base ligand and its cis‐MoO₂ complex