Six-Membered Ring Systems: Diazines and Benzo Derivatives

Rinderspacher, K. Alison

doi:10.1016/b978-0-12-819962-6.00013-0

Cited by 8 publications

(7 citation statements)

References 76 publications

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“…These compounds belong to a wide range of biological applications, such as antibacterial, anticancer, antifungal, antiviral, antiinflammatory, and so on. 1 In the last decades, the first compound, pyridazine, have received considerable attention due to their biological activities as antimicrobial agents and antiplatelet agents. 2 In addition, pyridazines, pyrazines, pyrimidines are used in the chemical industries as a starting or addition products for the synthesis of more complex compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Pyridazines, pyrazines, and pyrimidines, whose chemical structures are given in Figure 1, alongside all their benzoderivatives, present the core shell of a large variety of natural products and pharmaceutical drugs. These compounds belong to a wide range of biological applications, such as antibacterial, anticancer, antifungal, antiviral, anti‐inflammatory, and so on 1 …”

Section: Introductionmentioning

confidence: 99%

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Gas‐phase OH oxidation kinetics of pyrazine, pyrimidine, and pyridazine

Samir

Kalalian

Roth

et al. 2021

Int J of Chemical Kinetics

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The gas-phase kinetics of the OH-oxidation of three six-membered nitrogen heterocycles C 4 N 2 H 4 isomers, namely pyrazine, pyrimidine, and pyridazine, were determined in a photochemical reactor coupled to a FTIR spectrometer and a SPME-GC/MS, at atmospheric pressure over the temperature range 298-353 K. Experiments were conducted using the relative rate method where two different references were employed for each studied compound. The obtained Arrhenius expressions are (in cm 3 molecule -1 s -1 ) OH+pyrazine ( ) = (7.21 ± 1.57) × 10 −13 exp (− (166 ± 71) ∕ ) , OH+pyrimidine ( ) = (1.18 ± 0.57) × 10 −12 exp (− (362 ± 155) ∕ ) , OH+pyridazine ( ) = (9.82 ± 7.20) × 10 −12 exp (− (1063 ± 248) ∕ ) .These results were compared with available literature data for other heterocyclic compounds and discussed in terms of structure-reactivity and temperature dependency. Their tropospheric lifetimes with respect to reaction with OH radicals were then calculated and found to be of the order of 29, 34, and 37 days for pyrazine, pyrimidine, and pyridazine, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gas‐phase OH oxidation kinetics of pyrazine, pyrimidine, and pyridazine

Samir

Kalalian

Roth

et al. 2021

Int J of Chemical Kinetics

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“…Currently, new diazine-based natural substance products continue to be isolated and studied, and both they and synthetic derivatives are frequently used as flavorings or pharmaceuticals. Their diverse properties due to their structure give them a wide range of applications, ranging from medical chemistry to electrochemistry [126][127][128].…”

Section: Diazinesmentioning

confidence: 99%

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

et al. 2021

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Over the past two decades, polyoxometalates (POM) have received considerable attention as solid catalysts, due to their unique physicochemical characteristics, since, first, they have very strong Bronsted acidity, approaching the region of a superacid, and second, they are efficient oxidizers that exhibit rapid redox transformations under fairly mild conditions. Their structural mobility is also highlighted, since they are complex molecules that can be modified by changing their structure or the elements that compose them to model their size, charge density, redox potentials, acidity, and solubility. Finally, they can be used in substoichiometric amounts and reused without an appreciable loss of catalytic activity, all of which postulate them as versatile, economic and ecological catalysts. Therefore, in 2009, we wrote a review article highlighting the great variety of organic reactions, mainly in the area of the synthesis of bioactive heterocycles in which they can be used, and this new review completes that article with the contributions made in the same area for the period 2010 to 2020. The synthesized heterocycles to be covered include pyrimidines, pyridines, pyrroles, indoles, chromenes, xanthenes, pyrans, azlactones, azoles, diazines, azepines, flavones, and formylchromones, among others.

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“…On the other hand, diazins can represent pyrimidines (e.g., nucleic acids) but also many natural products and biologically active compounds (e.g. Rinderspacher 2014). The remainder pyrolysis components in VAN-002 included alkanes (consisting of 1-heptene (2.5%), 1-octene (2.6)), acetic acid (7.3%), undecanoic acid (5.2%), oxy-acetic acid (3.0%), and cyclohexanone (1.6%).…”

Section: Organic Carbon and Microbiological Edna Analysis -Tablementioning

confidence: 99%

The ecology and bioactivity of some Greco-Roman medicinal minerals: the case of Melos earth pigments

Knapp

Christidis

Venieri

et al. 2021

Archaeol Anthropol Sci

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Mineral compounds, as pigments and therapeutics, appeared regularly in the technical and medical texts of the Greco-Roman (G-R) world. We have referred to them as ‘G-R medicinal minerals’ and we suggest that despite their seeming familiarity, there are actually many unknowns regarding their precise nature and/or purported pharmacological attributes. Earth pigments are part of that group. This paper presents a brief overview of our work over the past twenty years relating to: a. the attempt to locate a select number of them in the places of their origin; b. their chemical/mineralogical characterization; c. the study of their ecology via the identification of the microorganisms surrounding them; d. their testing as antibacterials against known pathogens. In the process, and to fulfil the above, we have developed a novel methodological approach which includes a range of analytical techniques used across many disciplines (mineralogy, geochemistry, DNA extraction and microbiology). This paper focuses on a select number of earth pigments deriving from the island of Melos in the SW Aegean, celebrated in antiquity for its Melian Earth, a white pigment, and asks whether they might display antibacterial activity. We demonstrate that some (but not all) yellow, green and black earth pigments do. We also show that the manner in which they were dispensed (as powders or leachates) was equally important. The results, although preliminary, are informative. Given their use since deep time, earth pigments have never lost their relevance. We suggest that the study of their ecology/mineralogy and potential bioactivity allows for a better understanding of how our perception of them, as both pigments and therapeutics, may have evolved.

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Six-Membered Ring Systems: Diazines and Benzo Derivatives

Cited by 8 publications

References 76 publications

Gas‐phase OH oxidation kinetics of pyrazine, pyrimidine, and pyridazine

Gas‐phase OH oxidation kinetics of pyrazine, pyrimidine, and pyridazine

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

The ecology and bioactivity of some Greco-Roman medicinal minerals: the case of Melos earth pigments

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