Six-Minute Walk Test

Agarwala, Priya; Salzman, Steve H.

doi:10.1016/j.chest.2019.10.014

Cited by 210 publications

(120 citation statements)

References 56 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Perhaps future studies could implement a similar intervention strategy, while elucidating the physiological mechanisms that underpin such positive changes, including muscle-tendon complex adaptation (e.g., neuromuscular adaptation), serum lipid transporters (e.g., LPL), and biological markers of inflammation (interleukin 6, tumor necrosis factor alpha, and C-reactive protein). Future studies should also investigate the effects of SB displacement on validated QoL assessments in older adults (e.g., SF-36 and EQ-5D; Bohannon and DePasquale, 2010), as-well as comprehensive physical capacity assessments [e.g., 6 min walk test (6MWT; Agarwala and Salzman, 2020)].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Displacing Sedentary Behavior With Two Distinct Patterns of Light Activity on Health Outcomes in Older Adults (Implications for COVID-19 Quarantine)

et al. 2020

View full text Add to dashboard Cite

Rationale: The COVID-19 pandemic is limiting outdoor and community-based activities, especially for older adults owing to the requirement for self-isolation, potentially increasing prolonged sedentary behavior (SB). Given a poor tolerance for intense exercise, SB displacement with light intensity physical activity (LIPA) is a promising health enhancing alternative. Therefore, the aims of this study were to investigate the effects of two different types of SB displacement on health outcomes in older adults and any differential impact of associated LIPA pattern.Method: 28 older women (age: 73 ± 5 years, height: 1.60 ± 0.07 m, weight: 67 ± 10 kg, and BMI: 26.1 ± 3.6 kg/m2) underwent overnight fasted dual energy x-ray absorptiometry (DEXA) imaging, blood sampling, and functional assessments before being randomly allocated to one of two groups: (1) single continuous bout of 45–50 min LIPA daily (n = 14); or (2) SB fragmentation (SBF; ~48 min LIPA daily, 2 min LIPA for every 30 min of SB; n = 14). Compliance was systematically monitored using tri-axial accelerometery. All measures were taken at weeks 0 and 8.Results: Physical behavior significantly altered (decreased SB/increased LIPA; p < 0.05) and to a similar extent in both groups. We observed a significant reduction in serum triglycerides [p = 0.045, effect size (ɳp2) = 0.15; SBF: −0.26 ± 0.77 mmol/L, LIPA: −0.26 ± 0.51 mmol/L], improved 30 s sit-to-stand (STS) count (p = 0.002, ɳp2 = 0.32, 2 ± 3 STS) and speed (p = 0.009, ɳp2 = 0.35, −10 ± 33%), as well as increased average handgrip strength (p = 0.001, ɳp2 = 0.45, 6 ± 12%), and gait speed (p = 0.005, ɳp2 = 0.27, 0.09 ± 0.16 m/s) in both groups. Interestingly, SBF caused a greater increase in peak handgrip strength (8 ± 14%), compared to LIPA (2 ± 10%; p = 0.04, ɳp2 = 0.38).Conclusion: SB displacement induced significant improvements in fasting triglycerides, gait speed, as-well as STS endurance/speed in older women. Frequent vs. continuous SB displacement also caused greater increases in handgrip strength. While both SB displacement protocols display promise as efficacious home-based interventions for self-isolating older adults, our results would suggest a physical functioning advantage of the SBF protocol for certain outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effects of Displacing Sedentary Behavior With Two Distinct Patterns of Light Activity on Health Outcomes in Older Adults (Implications for COVID-19 Quarantine)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…117 The 6-min walk test (cut-off <350 m) predicts mortality and morbidity in COPD patients and can therefore be used to stratify patients to functional capacity. 118,119 It does not require specialized equipment, but does need a 30 meters long corridor, which might make it more feasible in research settings than in everyday clinical assessment.…”

Section: Physical Performancementioning

confidence: 99%

Towards Personalized Management of Sarcopenia in COPD

Bakel¹,

Gosker²,

Langen³

et al. 2021

COPD

View full text Add to dashboard Cite

“…6MWT, 12MWT and 3MSC provide a comprehensive measure of the cardiovascular and the respiratory apparatus as well as of the osteo-articular system function [158,159].…”

Section: Endurance and Mobility Issuesmentioning

confidence: 99%

Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations

Parini

Deodato

2020

IJMS

View full text Add to dashboard Cite

The aim of this review is to summarize the evidence on efficacy, effectiveness and safety of intravenous enzyme replacement therapy (ERT) available for mucopolysaccharidoses (MPSs) I, II, IVA, VI and VII, gained in phase III clinical trials and in observational post-approval studies. Post-marketing data are sometimes conflicting or controversial, possibly depending on disease severity, differently involved organs, age at starting treatment, and development of anti-drug antibodies (ADAs). There is general agreement that ERT is effective in reducing urinary glycosaminoglycans and liver and spleen volume, while heart and joints outcomes are variable in different studies. Effectiveness on cardiac valves, trachea and bronchi, hearing and eyes is definitely poor, probably due to limited penetration in the specific tissues. ERT does not cross the blood–brain barrier, with the consequence that the central nervous system is not cured by intravenously injected ERT. All patients develop ADAs but their role in ERT tolerance and effectiveness has not been well defined yet. Lack of reliable biomarkers contributes to the uncertainties about effectiveness. The data obtained from affected siblings strongly indicates the need of neonatal screening for treatable MPSs. Currently, other treatments are under evaluation and will surely help improve the prognosis of MPS patients.

show abstract

Six-Minute Walk Test

Cited by 210 publications

References 56 publications

The Effects of Displacing Sedentary Behavior With Two Distinct Patterns of Light Activity on Health Outcomes in Older Adults (Implications for COVID-19 Quarantine)

The Effects of Displacing Sedentary Behavior With Two Distinct Patterns of Light Activity on Health Outcomes in Older Adults (Implications for COVID-19 Quarantine)

Towards Personalized Management of Sarcopenia in COPD

Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations

Contact Info

Product

Resources

About