Six-minute walk test versus two-minute walk test in children with Duchenne muscular dystrophy: Is more time more information?

Vill, Katharina; Ille, Lena; Schroeder, Sebastian A.; Blaschek, Astrid; Müller‐Felber, Wolfgang

doi:10.1016/j.ejpn.2015.08.002

Cited by 20 publications

(21 citation statements)

References 15 publications

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“…Yet little is known about the usefulness of the 2MWT especially in pediatric population, but recent studies support the ability of the 2MWD to predict the 6MWD, specifically in the pediatric neuromuscular disease population. 18,26 Our results give further evidence, that a 2MWT might be a suitable alternative. Shortening the test would lower the risk of falling and increase motivation, which is a severe problem especially in patients with more advanced stages of DMD.…”

Section: Do We See Progredient Fatigue In the Intraindividual Course supporting

confidence: 62%

“…Since a previous study 18 of ours showed that-due to reasons of motivation-the speed during the first minute of the 6MWT was constantly higher than in the following minutes, we selected the ratio between the second and the sixth minute of the 6MWT for the assessment of fatigue due to neuromuscular problems. A ratio of (distance min 2)/(distance min 6) >1 was used as an indicator of exercise-induced fatigue.…”

Section: Methodsmentioning

confidence: 99%

“…Our findings, however, represent a strong argument that shortening the walking distance would not be associated with a relevant loss of informative value. 18 Is Exercise-Induced Fatigue Therefore an Argument against the Establishment of the 2MWT As a Primary Outcome Parameter?…”

Section: Do We See Progredient Fatigue In the Intraindividual Course mentioning

confidence: 99%

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Is Exercise-Induced Fatigue a Problem in Children with Duchenne Muscular Dystrophy?

et al. 2020

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Objective Duchenne muscular dystrophy (DMD) is a devastating X-linked muscular disorder. The number of studies investigating new therapeutic approaches is substantially increasing. This study aims to investigate the impact and diagnostic value of exercise-induced fatigue in DMD, which has been proposed as a suitable outcome parameter in other conditions like spinal muscular atrophy. Patients and Methods A cohort of 55 DMD patients (49 of them treated with steroids and 9 with ataluren) underwent a total of 241 6MWT (mean 4.4 tests/patient) which were retrospectively analyzed. Exercise-induced fatigue was assessed by the ratio between the distance achieved in the sixth minute and the distance in the second minute of the 6MWT. In previous studies a quotient above 1 was defined as a sign of fatigue. Results The average fatigue quotient in the whole cohort of patients was 1.0. In a further analysis no impact of age, steroid therapy, ataluren therapy, overall disability, and distance in the 6-minute walk test (6MWT) on fatigue in DMD patients could be shown. Conclusion Our data show that fatigue does not play a relevant role in DMD. Analysis of fatigue is not a useful outcome parameter in DMD studies. For this reason we suggest the 2MWT, which is better accepted by the patients, as an alternative to the commonly 6MWT.

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Section: Do We See Progredient Fatigue In the Intraindividual Course supporting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

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Is Exercise-Induced Fatigue a Problem in Children with Duchenne Muscular Dystrophy?

et al. 2020

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“…T he 2-minute walk test (2MWT) and 6-minute walk test (6MWT) are used to evaluate walking capacity in patients with neuromuscular diseases (NMD) in the clinic and in clinical trials. However, reliability of the 2MWT has been documented only in Duchenne muscular dystrophy (1) and reliability of the 6MWT has been documented only in Duchenne muscular dystrophy (1,2), myotonic dystrophy (3), and spinal and bulbar muscular atrophy (4). Relative reliability characterizes the trustworthiness of a test in a specific diagnosis.…”

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confidence: 99%

“…Each dot represents a single patient. Various (6): spinal muscular atrophy (3), myotonia congenital Thomsen disease (1), congenital myopathy (1) and polymyositis(1). A + B: The Bland-Altman plots show the change in walking distance between repeated tests for each patient compared with mean ± 1.96 standard deviation (SD) for all NMD as a group.…”

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confidence: 99%