Size- and pathotropism-driven targeting and washout-resistant effects of boronic acid-rich protein nanoparticles for liver cancer regression

Wang, Jing; Zhang, Zhaoheng; Wang, Xin; Wu, Wei; Jiang, Xiqun

doi:10.1016/j.jconrel.2013.02.019

Cited by 49 publications

(32 citation statements)

References 34 publications

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“…The ability of PBA to form reversible covalent complexes with 1,2-or 1,3-diols (Cambre and Sumerlin, 2011) is desirable for many medical and pharmaceutical applications such as glucose sensing (Wu et al, 2012;Zhang et al, 2013), glucose-sensitive insulin controlled release (Wu et al, 2010), cancer targeting delivery (Wang et al, 2014(Wang et al, , 2013b, liver targeting delivery (Wang et al, 2013a) and gene delivery (Piest et al, 2013). It is worth noticing that recently, PBA moiety has been used to confer biomaterials affinity to mucin, since oligosaccharides in mucin provide plenty of binding sites for PBA (Zheng et al, 2013).…”

mentioning

confidence: 99%

Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Liu

Yan

et al. 2015

International Journal of Pharmaceutics

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mentioning

confidence: 99%

Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Liu

Yan

et al. 2015

International Journal of Pharmaceutics

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“…Besides, the fluorescence intensity of FITC-Gal(oct)-coix oil-MEs was 1.4-fold lower than that of FITC-Gal(oct)-C-MEs, further validating that coixan and galactose ester synergistically enhanced internalization. The internalization mechanism of Gal(oct)-C-MEs was studied using various specific inhibitors or treatment, such as 4°C/NaN 3 (energy inhibitor), NH 4 Cl (lyso-endosomers endocytosis inhibitor), sucrose (clathrin-mediated endocytosis inhibitor), genistein (caveolae-mediated endocytosis inhibitor) and amiloride (macropinocytosis inhibitor). 22 As displayed in Figure 4C, the cellular uptake greatly reduced when the cells were cultured under low temperature, as well as when treated with NaN 3 , suggesting that Gal(oct)-C-MEs entered the tumor cells in a energy-dependent manner.…”

Section: Cellular Uptakementioning

confidence: 99%

“…22 As displayed in Figure 4C, the cellular uptake greatly reduced when the cells were cultured under low temperature, as well as when treated with NaN 3 , suggesting that Gal(oct)-C-MEs entered the tumor cells in a energy-dependent manner. In addition, the cellular uptake was also inhibited after treatment with NH 4 Cl and sucrose, suggesting that Gal(oct)-C-MEs crossed the cell membrane by clathrin-mediated pathway and was consequently entrapped by lyso-endosomers.…”

Section: Cellular Uptakementioning

confidence: 99%

“…2 Although chemotherapy is a most commonly used and effective approach for treatment of HCC, the severe systemic side effects resulting from nonselective biodistribution still enormously restrict the clinical applications. 3,4 Recently, nano-sized drug delivery system (DDS) showed a promising potentiality in tumor-specific accumulation by enhanced permeability and retention (EPR) effect. …”

Section: Introductionmentioning

confidence: 99%

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Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Qu¹,

Liu²,

Huang³

et al. 2017

IJN

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A nanosized drug delivery platform with a combination of rational components and tumor targeting is significant for enhancement of anticancer therapy and reduction of side effects. In this study, we developed a octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components (Gal(oct)-C-MEs), which improved the tumor accumulation through asialoglycoprotein receptor-mediated endocytosis and promoted the antitumor efficacy through multicomponent-mediated synergistic effect. Octanoyl galactose ester (Gal(oct)) with a yield of 82.3% was synthesized through a green enzymatic reaction and multidimensional characterization. Gal(oct)-C-MEs with a spherical shape had a small and uniform particle size (58.49±1.03 nm), narrow polydispersity index (0.09±0.01) and neutral surface charge (−5.82±0.57 mV). In the cellular uptake studies, the internalized Gal(oct)-C-ME was 2.28-fold higher relative to that of coix seed component-based microemulsions (C-MEs). The half-maximal inhibitory concentration of Gal(oct)-C-MEs against HepG2 cells was 46.5±2.4 μg/mL, which was notably higher than that of C-MEs. Importantly, the intratumor fluorescence of HepG2 xenograft-bearing nude mice treated with Cy5/Gal(oct)-C-MEs was 1.9-fold higher relative to treatment with Cy5/C-MEs. In the study of antitumor efficacy in vivo, HepG2 xenograft-bearing nude mice intragastrically administered Gal(oct)-C-MEs for 14 days exhibited the strongest inhibition of tumor growth and the lowest toxicity against liver and kidney among all the treatments. In summary, Gal(oct)-C-ME, as a highly effective and safe anticancer drug delivery system, showed promising potential for hepatoma therapy.

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“…The first layer applied to the citrate gold particles was Hexadecathiol (Sigma Aldrich) dissolved in ethanol [311]. While stirring, 20 mL pure ethanol (Decon Labs) was placed in a breaker with 60 μL 1-Hexadecathiol being added secondly.…”

Section: Particle Functionalizationmentioning

confidence: 99%

Study of novel nanoparticle transport and drug release for cancer treatment.

Gene¹

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Nano-scale particles sized 10-400 nm administered systemically preferentially extravasate from tumor vasculature due to the enhanced permeability and retention effect. Therapeutic success remains elusive, however, because of inhomogeneous particle distribution within tumor tissue. Insufficient tumor vascularization limits particle transport and also results in avascular hypoxic regions with non-proliferating cells, which can regenerate tissue after nanoparticle-delivered cytotoxicity or thermal ablation. In this study, gold nanoparticles were functionalized with phosphatidylcholine (two-layer) or phosphatidylcholine and HDL (three-layer) in the formation of "layered" nanoparticles. The diffusivity of both two-and three layered colloidal gold nanoparticles and silica gold nanoshells were examined in 3D cell cultures. Both two-and three layered nanoparticles showed enhanced diffusivity in comparison to previously developed PEGylated nanoparticles. As the two layer nanoparticles displayed enhanced diffusivity in comparison to three layer nanoparticles, the two layered nanoparticles were further examined in vivo using mice implanted with orthotopic pancreatic adenocarcinomas. The two layer colloidal gold nanoparticles showed enhanced diffusivity in comparison to silica gold nanoshells in vivo, suggesting that smaller nanoparticles were able to localize and diffuse from vasculature better than larger nanoparticles. Overall accumulation of solid gold nanoparticle accumulated in the tumor and filtering organs (liver and spleen) was 2X higher than silica gold nanoshells. Thus, two layer colloidal gold nanoparticles were loaded with cisplatin or paclitaxel to determine optimal drug release kinetics. Drug release from paclitaxel-loaded nanoparticles displayed a slower release while cisplatin-loaded nanoparticles experienced an initial burst of drug release followed by a slower release of remaining drug. Lastly, drug-loaded colloidal gold nanoparticles were tested in 3D cell cultures to determine their cytotoxicity. Both two and three layer nanoparticles loaded with cisplatin or v paclitaxel showed similar efficacy to drug alone, suggesting their viable use in vivo for cancer treatment.This study has demonstrated the potential use of layered nanoparticles for increasing the delivery of chemotherapeutics deeper into tumor tissue.

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Size- and pathotropism-driven targeting and washout-resistant effects of boronic acid-rich protein nanoparticles for liver cancer regression

Cited by 49 publications

References 34 publications

Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles

Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Study of novel nanoparticle transport and drug release for cancer treatment.

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