Size-Controlled Self-Assembly of Superparamagnetic Polymersomes

Hickey, Robert J.; Koski, Jason; Meng, Xin; Riggleman, Robert A.; Zhang, Peijun; Park, Soo‐Young

doi:10.1021/nn405012h

Cited by 121 publications

(111 citation statements)

References 48 publications

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“…[55] The formation of polymersomes was favored with the addition SPIONs by reducing the entropy penalty. SPIONs with a diameter of 5.8 nm were dispersed in the bilayer of larger polymersomes with diameters of 513 nm.…”

Section: Controlling Physicochemical Properties Of Polymersome Membranementioning

confidence: 99%

Engineering Polymersomes for Diagnostics and Therapy

Leong

Teo

Aakalu

et al. 2018

Adv Healthcare Materials

113

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Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self-assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli- responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.

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Section: Controlling Physicochemical Properties Of Polymersome Membranementioning

confidence: 99%

Engineering Polymersomes for Diagnostics and Therapy

Leong

Teo

Aakalu

et al. 2018

Adv Healthcare Materials

113

View full text Add to dashboard Cite

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“…[1][2][3][4][5][6] Various hybrid co-assemblies were developed with the controllable morphologies including sphere 7,8 , cylindrical 9, 10 , vesicles 11,12 , and other complex structures ranging from zero to three dimensions [13][14][15] . [19][20][21][22][23] By varying precursor composition [24][25][26][27] or environmental parameters 28,29 in co-assembly, various inorganic components such as nanoparticles (NPs) and nanorods have been located selectively in the different portion of the hybrid coassemblies. Since the spatial distribution of the nanoparticles in hybrid materials is one of the critical factors to determine the properties of the obtained hybrid structure [16][17][18] , many efforts have been made towards preparing the hybrid coassemblies with the controllable location of inorganic component in polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

Dynamic control of the location of nanoparticles in hybrid co-assemblies

Jiang

et al. 2015

Nanoscale

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We herein demonstrated an approach to control the spatial distribution of components in hybrid microspheres. Hybrid core-shell structured microspheres (CSMs) prepared through co-assembly were used as starting materials, which are comprised of anthracene-ended hyperbranched poly(ether amine) (AN-hPEA) in the shell and crystallized anthracene containing polyhedral oligomer silsesquioxane (AN-POSS). Upon thermal annealing at a temperature higher than the melting point of AN-POSS, the diffusion of AN-POSS from the core to the shell of CSM leads to a transition of morphology from the core-shell structure to core-transition-shell to the more stable homogeneous morphology, which has been revealed by experimental results of TEM and DSC. The mechanism for the morphology transition of CSM induced by the diffusion of AN-POSS was disclosed by a dissipative particle dynamics (DPD) simulation. A mathematical model for the diffusion of POSS in the hybrid microsphere is established according to Fick's law of diffusion and can be used to quantify its distribution in CSM. Thus, the spatial distribution of POSS in the microsphere can be controlled dynamically by tuning the temperature and time of thermal annealing.

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“…All JVs consist of a hollow cavity and a membrane composed of BCP-tethered AuNPs, MNPs, and free BCPs, as indicated by the higher contrast at the edges and the wrinkle surface—which are two characteristics typical of vesicles—of the assemblies displayed in the TEM images (Figure 2a,b; Supporting Information, Figure S2b). [10] The average diameter of the JVs was 570.8 ± 93.2 nm, characterized by dynamic light scattering (Supporting Information, Figure S4). Within the vesicular membranes of JVs, the BCP-tethered AuNPs were segregated and densely packed in one half of the vesicular membrane, while the hydrophobic MNPs could be clearly observed in the polymeric domains in another half of the vesicles.…”

mentioning

confidence: 99%

Magneto‐Plasmonic Janus Vesicles for Magnetic Field‐Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

et al. 2016

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Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field.

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Size-Controlled Self-Assembly of Superparamagnetic Polymersomes

Cited by 121 publications

References 48 publications

Engineering Polymersomes for Diagnostics and Therapy

Engineering Polymersomes for Diagnostics and Therapy

Dynamic control of the location of nanoparticles in hybrid co-assemblies

Magneto‐Plasmonic Janus Vesicles for Magnetic Field‐Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

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