Size effect of dynamic bioactive magnetic particles on regulated isolation of tumor cells

Qin, Rong; Bai, Mengqi; Yang, Kaitong; Huo, Yaning; Wang, Zengkai; Tian, Xiaohua; Cheng, Kai; Zhang, Feiyi; Yang, Yuhe; Dong, Mingdong; Hou, Shuai; Liu, Lei

doi:10.1016/j.apsusc.2024.159959

Cited by 1 publication

(1 citation statement)

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“…Up to now, immunomagnetic capture methods have been more commonly studied. Qin et al used polydopamine (PDA) coating and produced dynamic magnetic particles (DBMPs) using phenylboric acid (PBA) through the reversible catechol–borate interaction [ 52 ]. Mohamadi’s team combined the velocity valley chip with an integrated circuit, which has the ability to directly analyze the gene expression of CTCs in the manner shown in Figure 3 A, avoiding the shortcomings of immunostaining methods that are slow to observe CTCs [ 53 ].…”

Section: Label-dependent Methodsmentioning

confidence: 99%

Novel Isolating Approaches to Circulating Tumor Cell Enrichment Based on Microfluidics: A Review

Qiao,

Teng,

Liu

et al. 2024

Micromachines

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Circulating tumor cells (CTCs), derived from the primary tumor and carrying genetic information, contribute significantly to the process of tumor metastasis. The analysis and detection of CTCs can be used to assess the prognosis and treatment response in patients with tumors, as well as to help study the metastatic mechanisms of tumors and the development of new drugs. Since CTCs are very rare in the blood, it is a challenging problem to enrich CTCs efficiently. In this paper, we provide a comprehensive overview of microfluidics-based enrichment devices for CTCs in recent years. We explore in detail the methods of enrichment based on the physical or biological properties of CTCs; among them, physical properties cover factors such as size, density, and dielectric properties, while biological properties are mainly related to tumor-specific markers on the surface of CTCs. In addition, we provide an in-depth description of the methods for enrichment of single CTCs and illustrate the importance of single CTCs for performing tumor analyses. Future research will focus on aspects such as improving the separation efficiency, reducing costs, and increasing the detection sensitivity and accuracy.

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Section: Label-dependent Methodsmentioning

confidence: 99%