Size-Templating Matrix Effect in Vesicle Formation. 2. Analysis of a Macroscopic Model

Bolton, Colin D; Wattis, Jonathan A. D.

doi:10.1021/jp034590+

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…Some theoretical studies on vesicles have also been carried out by Bolton and Wattis, , and more recently by Božič, who interestingly introduce the hydraulic permeability in the analysis.…”

Section: The “Matrix Effect”mentioning

confidence: 99%

Vesicle Behavior: In Search of Explanations

Luisi¹,

Souza²,

Stano³

2008

J. Phys. Chem. B

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In this paper we will present a series of experiments in the general field of surfactant aggregates and, in particular, in vesicle chemistry, which have found no definitive explanation until now. These experiments concern vesicle self-reproduction (in particular, the so-called matrix effect); the interaction between vesicle and RNA, where RNA appears capable of discriminating between vesicles differing slightly in size; the fusion of oppositely charged vesicles, which brings about unexpected behavior of size distribution; and some aspects of local concentration inside vesicles, which still lack clarification in terms of local versus overall concentration. The theoretical and experimental implications of this not yet understood behavior will be discussed, emphasizing that progress in the field must face the difficulty of applying thermodynamics to these kinetically trapped systems, and the general difficulty of understanding how kinetic and thermodynamic factors interplay with each other.

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Section: The “Matrix Effect”mentioning

confidence: 99%

Vesicle Behavior: In Search of Explanations

Luisi¹,

Souza²,

Stano³

2008

J. Phys. Chem. B

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“…In this rapidly progressing field, different theoretical approaches have been recently proposed at different levels of complexity, and making the underlying chemistry more or less explicit in the model. Bolton and Wattis focused on early examples of chemical autopoiesis studying the time evolution of the size distribution of autopoietic vesicles [16][17][18] by means of a deterministic kinetic stepwise aggregation model: The Becker-Döring model. In this approach a vesicle is described only in terms of its aggregation number or its size, i.e.…”

Section: Introductionmentioning

confidence: 99%

Recent Theoretical Approaches to Minimal Artificial Cells

Mavelli

Altamura

Cassidei

et al. 2014

Entropy

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Minimal artificial cells (MACs) are self-assembled chemical systems able to mimic the behavior of living cells at a minimal level, i.e. to exhibit self-maintenance, self-reproduction and the capability of evolution. The bottom-up approach to the construction of MACs is mainly based on the encapsulation of chemical reacting systems inside lipid vesicles, i.e. chemical systems enclosed (compartmentalized) by a double-layered lipid membrane. Several researchers are currently interested in synthesizing such simple cellular models for biotechnological purposes or for investigating origin of life scenarios. Within this context, the properties of lipid vesicles (e.g., their stability, permeability, growth dynamics, potential to host reactions or undergo division processes…) play a central role, in combination with the dynamics of the encapsulated chemical or biochemical networks. Thus, from a theoretical standpoint, it is very important to develop kinetic equations in order to explore first-and specify later-the conditions that allow the robust implementation of these complex chemically reacting systems, as well as their controlled reproduction. Due to being compartmentalized in small volumes, the population of reacting molecules can be very low in terms of the number of molecules and therefore their behavior becomes highly affected by stochastic effects both in the time course of reactions and in occupancy distribution among the vesicle population. In this short review we report our mathematical approaches to model artificial cell systems in this complex scenario by giving a summary of three recent simulations studies on the topic of primitive cell (protocell) systems. OPEN ACCESSEntropy 2014, 16 2489

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“…A similar model has been analysed by Wu [23]. Multi-component Becker-Döring systems have been used in several models of the kinetics of vesicle formation [9,6,7]. However, the situations under consideration in this paper require Smoluchowski [16] aggregation rather than the restricted stepwise growth of BeckerDöring models.…”

Section: Introductionmentioning

confidence: 99%

Exact solutions for cluster-growth kinetics with evolving size and shape profiles

Wattis¹

2006

J. Phys. A: Math. Gen.

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Abstract. In this paper we construct a model for the simultaneous compaction by which clusters are restructured, and growth of clusters by pairwise coagulation. The model has the form of a multicomponent aggregation problem in which the components are cluster mass and cluster diameter. Following suitable approximations, exact explicit solutions are derived which may be useful for the verification of simulations of such systems. Numerical simulations are presented to illustrate typical behaviour and to show the accuracy of approximations made in deriving the model. The solutions are then simplified using asymptotic techniques to show the relevant timescales of the kinetic processes and elucidate the shape of the cluster distribution functions at large times.

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Size-Templating Matrix Effect in Vesicle Formation. 2. Analysis of a Macroscopic Model

Cited by 8 publications

References 19 publications

Vesicle Behavior: In Search of Explanations

Vesicle Behavior: In Search of Explanations

Recent Theoretical Approaches to Minimal Artificial Cells

Exact solutions for cluster-growth kinetics with evolving size and shape profiles

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