Size-tunable supramolecular nanoparticles mediated by ternary cucurbit[8]uril host–guest interactions

Abstract

The formation of size-tunable, supramolecular nanoparticles (SNPs), employing cucurbit[8]uril-assisted naphthol-viologen charge-transfer complexes, is strongly time and temperature dependent. Yet, the ternary complex formation is fast at all temperatures employed. This indicates that SNP formation requires dynamic disassembly and reassembly of the constituting ternary complex units.

Photoresponsive Cucurbit[8]uril‐Mediated Adhesion of Bacteria on Supported Lipid Bilayers

“…MV-SH was synthesized as previously reported in literature. [ 51 ] The AzoMan glycoconjugate was also synthesized as previously reported in literature. [ 19 ] Both ORN178 and ORN208 bacterial strains were kindly provided by Prof. Luc Brunsveld, TU/e.…”

A High‐Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors

“…This strategy yields generally applicable protein modules whose assembly properties are not affected by the core protein. Driven by the supramolecular synthetic strategy, [15,[26][27][28][29][30] genes and proteins can be effectively incorporated together to form MFSNPs grafted with various functional molecules (Ad-PEG, Ad-PEG-RGD, and Ad-PEG-TAT) on their surface to achieve desired structural stability, delivery specificity, and cell transfusion capability, respectively. Moreover, because the gene and protein payloads are encapsulated inside the self-assembled MFSNPs, potential degradation [36] over the delivery process can be avoided.…”

“…Combining integrated microfluidic technologies [16][17][18][19][20][21][22][23][24][25] with a supramolecular synthetic strategy, [15,[26][27][28][29][30] we demonstrate herein a high-throughput approach for formulating and screening multifunctional supramolecular nanoparticles (MFSNPs) that are capable of simultaneous delivery of gene and functional proteins with superb efficiency and controllable stoichiometry among individual payloads ( Figure 1). As illustrated in Figure 1a, this approach utilized two microfluidic systems including a digital droplet generator (DDG; Supporting Information, Section 1.2-1.5, video available in Supporting Information) [20,22] and a microfluidic cell culture array [31,32] .…”

“…As illustrated in Figure 1a, this approach utilized two microfluidic systems including a digital droplet generator (DDG; Supporting Information, Section 1.2-1.5, video available in Supporting Information) [20,22] and a microfluidic cell culture array [31,32] . To enable the capability of on-chip synthesis of MFSNPs using the DDG, we developed a modular assembly system based on the supramolecular synthetic strategy [15,[26][27][28][29][30] (Figure 1b). By utilizing the molecular recognition between adamantane (Ad) and β-cyclodextrin (CD), a combinatorial library of DNA and proteins-encapsulated MFSNPs was generated by the DDG via systematically altering the ratios among the four functional modules.…”

Supramolecular bacterial systems

“…51 The Azo-Man glycoconjugate was also synthesized as previously reported in literature. 19 Both ORN178 and ORN208 bacterial strains were kindly provided by Prof.…”