Skeletal Muscle Changes Assessed by Preoperative Computed Tomography Images Can Predict the Long‐Term Prognosis of Stage III Colorectal Cancer

Yokoi, Keigo; Tanaka, Toshimichi; Kojo, Ken; Miura, Hirohisa; Yamanashi, Takahiro; Sato, Takeo; Yamashita, Keishi; Kumamoto, Yusuke; Hiki, Naoki; Naitoh, Takeshi

doi:10.1002/ags3.12532

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Results our present study show that patients in the lower SMR group suffered from lower continuation and a higher treatment stop rate due to the adverse effects associated with the postoperative CAPOX therapy. In our previous study, SMI in men and SMR in women were prognostic factors for Stage III colorectal cancer [11]. Based on these previous results, although we anticipated that SMI would also be a risk factor for the discontinuation of adjuvant chemotherapy, our present results did not show this (data not shown).…”

Section: Discussioncontrasting

confidence: 53%

“…Myopenia and myosteatosis could also be a prognostic factor in colorectal cancer (CRC) [1-4, 6, 8-10]. We previously demonstrated that skeletal muscle changes were a predictor of long-term prognosis in Stage III CRC [11]. In this previous study, low skeletal muscle index (SMI), which re ects myopenia, was the prognostic factor in men, while low skeletal muscle radiodensity (SMR) was the predictor in women.…”

Section: Introductionmentioning

confidence: 99%

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S048 Low skeletal muscle radiodensity is a risk factor for adjuvant chemotherapy discontinuation in colorectal cancer

Yokoi

Watanabe

Yokota

et al. 2023

Preprint

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Background Previously, we reported SMR (skeletal muscle radiodensity) as a potential prognostic marker for colorectal cancer. However, there have been limited studies on the association between SMR and the continuation of adjuvant chemotherapy in colorectal cancer. Methods In this retrospective study, 143 colorectal cancer patients underwent curative surgery and adjuvant chemotherapy using the CAPOX regimen. Patients' SMRs were measured from preoperative CT images and divided into low (bottom quarter) and high (top three quarters) SMR groups. We compared chemotherapy cycles, capecitabine and oxaliplatin doses, and adverse effects in each group. Results The low SMR group had significantly fewer patients completing adjuvant chemotherapy compared to the high SMR group (44% vs. 68%, P<0.01). Capecitabine and oxaliplatin doses were also lower in the low SMR group. Incidences of Grade 2 or Grade 3 adverse effects did not differ between groups, but treatment discontinuation due to adverse effects was significantly higher in the low SMR group. Logistic regression analysis revealed Stage III disease (odds ratio 9.30, 95% CI: 1.07-80.54) and low SMR (odds ratio 3.09, 95% CI: 1.07-8.94) as factors associated with unsuccessful treatment completion. Additionally, a higher proportion of low SMR patients received fewer than 2 cycles of chemotherapy (50% vs. 12%). Conclusion The low SMR group showed higher treatment incompletion rates and received lower drug doses during adjuvant chemotherapy. Low SMR independently contributed to treatment non-completion in colorectal cancer patients.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

S048 Low skeletal muscle radiodensity is a risk factor for adjuvant chemotherapy discontinuation in colorectal cancer

Yokoi

Watanabe

Yokota

et al. 2023

Preprint

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“…Each tissue type at the L3 level was evaluated in every CT image and marked with different colors (Figure 1). Sarcopenia was assessed through the skeletal muscle index (SMI), calculated as [SMA/height squared (m²)], while myosteatosis was assessed by the average SMA degeneration (17). The myosteatosis thresholds were set at 41 HU for patients with a body mass index (BMI) < 25 kg/m² and 33 HU for patients with a BMI ≥ 25 kg/m² (18).…”

Section: Body Composition Analysis Based On Ctmentioning

confidence: 99%

The coexistence of myosteatosis and the creatinine/cystatin C ratio are determinants of outcomes in cholangiocarcinoma patients undergoing curative surgery

Liu,

Zhang,

Song

et al. 2024

Front. Oncol.

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BackgroundMyosteatosis is a well-established predictor of poor prognosis in many types of cancer, and a decreased Creatinine/Cystatin C ratio (CCR) is a known indicator of unfavorable outcomes in patients with metabolic disorders and cancer. Despite this knowledge, the significance of concurrent CCR and myosteatosis in predicting the prognosis of patients with cholangiocarcinoma (CCA) who undergo radical surgery remains uncertain.MethodData from 757 patients with cholangiocarcinoma who underwent the first radical resection in the Affiliated Hospital of Qingdao University from January 2017 to March 2022 were collected. According to the inclusion and exclusion criteria, 149 patients were finally included in the retrospective study cohort. Various clinicopathological, serological, and radiological data were collected at admission. Myosteatosis was evaluated using sliceOmatic software on computed tomography (CT) images. The study used receiver operating characteristic (ROC) curve analysis to determine the critical value of CCR, which predicts overall survival (OS) based on the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were employed to identify the risk factors associated with OS and RFS confidently.ResultsThe group identified as the myosteatosis cohort consisted of 79 patients with an average age of 64.3 ± 7.8 years. The ROC curve analysis revealed an optimal critical CCR value of 10.834. A low CCR ≤ 10.834 and myosteatosis were found to be associated with poor OS and RFS outcomes (P = 0.022; P = 0.017; P = 0.038; P = 0.030 respectively). Moreover, patients with myosteatosis and a CCR ≤ 10.834 had the worst OS and RFS outcomes (P = 0.035; P = 0.027).ConclusionAfter radical excision in CCA patients, the presence of myosteatosis and CCR had a negative correlation with prognosis. A more accurate prediction of OS and RFS was possible by combining CCR and myosteatosis, compared to CCR alone.

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