Skeletal muscle mass and composition during mammalian hibernation

Cotton, Clark J.

doi:10.1242/jeb.125401

Cited by 64 publications

(57 citation statements)

References 144 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that minimal loss of musculoskeletal mass and function occurs in hibernating mammals, despite the fact that they experience suppressed neural activity and natural periods of prolonged musculoskeletal disuse (Bodine, 2013b;Cotton, 2016;McGee-Lawrence et al, 2008). This applies to many species, such as bears, squirrels, woodchucks, bats, hamsters, prairie dogs and marmots (Cotton, 2016;Cotton and Harlow, 2010;Doherty et al, 2012;James et al, 2011;McGee-Lawrence et al, 2015Utz et al, 2009;Wojda et al, 2012).…”

Section: Maintenance Of Musculoskeletal Properties In Hibernators Andmentioning

confidence: 99%

“…This applies to many species, such as bears, squirrels, woodchucks, bats, hamsters, prairie dogs and marmots (Cotton, 2016;Cotton and Harlow, 2010;Doherty et al, 2012;James et al, 2011;McGee-Lawrence et al, 2015Utz et al, 2009;Wojda et al, 2012). However, some small hibernators, such as the 13-lined ground squirrel (Ictidomys tridecemlineatus) have been reported to exhibit microstructural bone loss (osteocytic osteolysis) during hibernation bouts, which has not been observed in larger hibernating animals (McGeeLawrence et al, 2011).…”

Section: Maintenance Of Musculoskeletal Properties In Hibernators Andmentioning

confidence: 99%

“…Examinations of skeletal muscle changes (or lack thereof ) in mammalian hibernators have largely focused on rodents, bears and bats, with fewer studies investigating skeletal muscle changes in aestivating amphibians (Cotton, 2016;Hudson and Franklin, 2002b; Y. Maistrovski, Regulation of anti-apoptotic pathways in skeletal muscle and liver of an estivating species, Xenopus laevis, MSc thesis, Carleton University, Ontario, Canada, 2011). The morphological changes and remodelling of contractile performance that occur in the muscle of hibernating mammals and aestivating frogs have recently been extensively reviewed elsewhere (Cotton, 2016;James, 2010).…”

Section: Mechanisms Underpinning Inhibition Of Muscle Disuse Atrophymentioning

confidence: 99%

“…The morphological changes and remodelling of contractile performance that occur in the muscle of hibernating mammals and aestivating frogs have recently been extensively reviewed elsewhere (Cotton, 2016;James, 2010). Studies on muscle types from small hibernators such as hamsters, ground squirrels and bats have shown relatively small changes in both muscle mass and protein content during hibernation, with most reporting up to only 15% and 30% decreases in mass and protein, respectively (Cotton, 2016). Alterations in muscle protein content from hibernating bears have been shown to be similar to those of small mammalian hibernators, with an average decrease in muscle protein content of 5-10% (Cotton, 2016).…”

Section: Mechanisms Underpinning Inhibition Of Muscle Disuse Atrophymentioning

confidence: 99%

“…hibernation and aestivation; see Glossary) to survive unfavourable environmental conditions; these periods usually involve prolonged inactivity and fasting. Remarkably, hibernating mammals and aestivating frogs have been shown to exhibit negligible or no loss of musculoskeletal mass and strength, despite the fact that they experience natural periods of extended inactivity and starvation that can, in extreme cases, last for years (Cotton, 2016;Hudson and Franklin, 2002b;James, 2010;McGeeLawrence et al, 2008). The physiological adaptations of hibernating and aestivating animals may provide insight into why inactivityinduced muscle and bone loss occurs relatively rapidly in other vertebrate species, and might suggest novel potential treatments for these conditions in humans.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prevention of muscle wasting and osteoporosis: the value of examining novel animal models

Reilly

Franklin

2016

Journal of Experimental Biology

View full text Add to dashboard Cite

Bone mass and skeletal muscle mass are controlled by factors such as genetics, diet and nutrition, growth factors and mechanical stimuli. Whereas increased mechanical loading of the musculoskeletal system stimulates an increase in the mass and strength of skeletal muscle and bone, reduced mechanical loading and disuse rapidly promote a decrease in musculoskeletal mass, strength and ultimately performance (i.e. muscle atrophy and osteoporosis). In stark contrast to artificially immobilised laboratory mammals, animals that experience natural, prolonged bouts of disuse and reduced mechanical loading, such as hibernating mammals and aestivating frogs, consistently exhibit limited or no change in musculoskeletal performance. What factors modulate skeletal muscle and bone mass, and what physiological and molecular mechanisms protect against losses of muscle and bone during dormancy and following arousal? Understanding the events that occur in different organisms that undergo natural periods of prolonged disuse and suffer negligible musculoskeletal deterioration could not only reveal novel regulatory factors but also might lead to new therapeutic options. Here, we review recent work from a diverse array of species that has revealed novel information regarding physiological and molecular mechanisms that dormant animals may use to conserve musculoskeletal mass despite prolonged inactivity. By highlighting some of the differences and similarities in musculoskeletal biology between vertebrates that experience disparate modes of dormancy, it is hoped that this Review will stimulate new insights and ideas for future studies regarding the regulation of atrophy and osteoporosis in both natural and clinical models of muscle and bone disuse.

show abstract

Section: Maintenance Of Musculoskeletal Properties In Hibernators Andmentioning

confidence: 99%

Section: Maintenance Of Musculoskeletal Properties In Hibernators Andmentioning

confidence: 99%

Section: Mechanisms Underpinning Inhibition Of Muscle Disuse Atrophymentioning

confidence: 99%

Section: Mechanisms Underpinning Inhibition Of Muscle Disuse Atrophymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevention of muscle wasting and osteoporosis: the value of examining novel animal models

Reilly

Franklin

2016

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals

Fogarty¹,

Sieck²

2019

Comprehensive Physiology

View full text Add to dashboard Cite

Symmorphosis is a concept of economy of biological design, whereby structural properties are matched to functional demands. According to symmorphosis, biological structures are never over designed to exceed functional demands. Based on this concept, the evolution of the diaphragm muscle (DIAm) in mammals is a tale of two structures, a membrane that separates and partitions the primitive coelomic cavity into separate abdominal and thoracic cavities and a muscle that serves as a pump to generate intra-abdominal (P ab ) and intra-thoracic (P th ) pressures. The DIAm partition evolved in reptiles from folds of the pleural and peritoneal membranes that was driven by the biological advantage of separating organs in the larger coelomic cavity into separate thoracic and abdominal cavities, especially with the evolution of aspiration breathing. The DIAm pump evolved from the advantage afforded by more effectively generation of both a negative P th for ventilation of the lungs and a positive P ab for venous return of blood to the heart and expulsive behaviors such as airway clearance, defecation, micturition, and child birth. Didactic SynopsisThe DIAm separates abdominal and thoracic cavities; thus, it is a partition, and its evolution reflects that important role in isolating organs into separate thoracic and abdominal cavities. However, the DIAm is also a muscle, and is most often described as the principal pump muscle of inspiration. However, the DIAm also serves as a pump for generating both negative P th and positive P ab in other motor behaviors. Accordingly, the evolution of the DIAm is more complex and should be considered in the context of its dual physiological roles as a partition and muscular pump. In considering DIAm evolution, we adopt the guiding concept of symmorphosis or economy of design, where biological structures are not over designed for their functional roles. Thus, this is a tale of the evolution of two diaphragms, a partition and a muscular pump that separates thoracic and abdominal cavities but also affects generation of P th and P ab .

show abstract

Unexpected regulation pattern of the IKKβ/NF‐κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus)

Wei¹,

Gong²,

Fu³

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

As a typical hibernator, the Daurian ground squirrel (Spermophilus dauricus) spends considerable time in a state of reduced activity with prolonged fasting. Despite this, they experience little muscle atrophy and have thus become an interesting anti-disuse muscle atrophy model. The IKKβ/NF-κB signaling pathway is significant to muscle atrophy due to the protein degradation resulting from the upregulation of the E3 ubiquitin ligase MuRF1. The current study showed that the IKKβ/NF-κB signaling pathway and MuRF1 maintained relatively steady mRNA and protein expression levels, with little muscle atrophy observed in the soleus (slow-twitch, SOL) or extensor digitorum longus (fast-twitch, EDL) during hibernation (HIB); however, mRNA expression significantly increased in the SOL and EDL muscle during interbout arousal (IBA), as did the MuRF1 mRNA level in the SOL and MuRF1 protein level in the EDL. Interestingly, the expressions of p50 and MuRF1 significantly increased during HIB in the gastrocnemius (mixed muscle, GAS) and showed moderate atrophy, but dramatically decreased during IBA. Elevated IKKβ and p50 mRNA and protein expression in the cardiac muscle (CM) during HIB did not accompany increased MuRF1 expression or muscle wasting. Importantly, almost all increased or decreased indicators in the tested tissues recovered to pre-hibernation levels after HIB. This is the first study to report on the unexpected regulation of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in Daurian ground squirrels during hibernation. Furthermore, we found that different types of muscles exhibited different strategies to cope with prolonged hibernation-induced disuse muscle atrophy.

show abstract

Skeletal muscle mass and composition during mammalian hibernation

Cited by 64 publications

References 144 publications

Prevention of muscle wasting and osteoporosis: the value of examining novel animal models

Prevention of muscle wasting and osteoporosis: the value of examining novel animal models

Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals

Unexpected regulation pattern of the IKKβ/NF‐κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus)

Contact Info

Product

Resources

About