Skeletal muscle metastases from lung cancer

Kwas, H.; Zendah, I.; Ghedira, Habib

doi:10.1177/0218492312470571

Cited by 10 publications

(13 citation statements)

References 5 publications

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“…Lung cancer despite being the tumour that more metasta sizes to skeletal muscle, that occurrence is considered rare. Several the ories have been proposed to explain this unusual event as the following: skeletal muscle is an adverse environment for tumour cells because of the intermittent contraction of the muscle, lactic acid production and variation of blood flow; skeletal muscle can produce a strong immune response; and the resistance of skeletal muscle to tumour implantation, causes a slow progression of metastatic tumours [3] [4].…”

Section: Discussionmentioning

confidence: 99%

“…The lung adenocarcinoma histological type was the most often found in patients with muscle involvement and the diaphragm was the skeletal muscle most frequently affected (8%) [4]. However, in the literature, there are few cases of diaphragmatic metastasis secondary to lung cancer, and reports on this rare entity are most often found in association with the presence of gastrointestinal tumors [5]- [7].…”

Section: Discussionmentioning

confidence: 99%

“…The metastasis process described is haematogenous and lymphatic, with cases described of direct extension [4] [8]. Muscle metastases may be identified during the evolution of a known malignancy, or more rarely, may reveal the tumor [4], as in the case presented.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma

Rocha¹,

Clérigo²,

Fernandes³

et al. 2014

ALC

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Lung cancer is a leading cause of death due to malignancy worldwide. Diaphragmatic metastasis secondary to primary lung cancer is rare. In the literature, only a few cases have been described as the majority of cases of diaphragmatic metastasis which are secondary to gastrointestinal neoplasia. The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female patient with no history of active or passive smoking with progressive worsening fatigue, asthenia, malaise, and unquantified weight loss with three months of evolution, associated with pleuritic chest pain and edema of the lower limbs for fifteen days previous to hospital admission. Chest X-ray showed elevation of the right hemi-diaphragm and thoracic-abdominal-pelvic computed tomography revealed a complex multilobuled mass with neoformative characteristics intersecting the diaphragm and invading the dome liver and the right lung region. Biopsy of the mass was performed whose histological examination was consistent with moderately differentiated adenocarcinoma. Immunohistochemical examination was positive for cytokeratin 7 and negative forcytokeratin 20, suggesting primary lung tumor. A positron emission tomography was performed without uptake in other locations. Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with carboplatin and gemcitabine. The patient died six months after the diagnosis. The authors also present a brief theoretical discussion based on the current and scarce literature on this rare entity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma

Rocha¹,

Clérigo²,

Fernandes³

et al. 2014

ALC

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“…Lung cancer is the leading cause of cancer mortality in the United States, with an estimated 224,210 novel cases and 159,260 mortalities in 2014 (6). The malignant tumor can metastasize to almost every region of the body, including skeletal muscle, although this is rather rare (7). There is no consensus on the optimal therapeutic strategy for muscle metastasis, as it may be the end-stage presentation of lung cancer (8).…”

Section: Introductionmentioning

confidence: 99%

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

et al. 2015

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Abstract. Intramuscular myxoma (IMM) as a rare soft-tissue tumor arising from the muscles is completely benign. When IMM accompanies malignance, it may be misdiagnosed as muscle metastasis, and for this extremely rare concurrence, the subsequent treatment would vary accordingly. The current study presents, to the best of our knowledge, the first case of non-small cell lung cancer (NSCLC) concomitant with IMM mimicking skeletal muscle metastasis. A 64-year-old female was hospitalized with a history of chest discomfort and right lumbar pain that had persisted for four months. The computed tomography scan showed a lesion in the left upper lobe of the lung and the right psoas, respectively. Serum biomarkers for NSCLC were abnormal. A presumptive clinical diagnosis was compatible with left NSCLC and right psoas muscle metastasis (cT2aN3M1b, stage Ⅳ). Stage Ⅳ lung cancer would receive palliative treatment. However, the final diagnosis of synchronous left lung squamous cell carcinoma (cT2aN3M0, stage ⅢB) and IMM in the right psoas was confirmed by biopsy. The patient therefore underwent definitive chemoradiotherapy for lung carcinoma, and conservative treatment, including analgesics, for IMM. The diagnosis process for a malignant neoplasm concomitant with IMM is not straightforward due to a lack of clinical experience, and it significantly affects the tumor staging and subsequent treatment strategy. The present case suggests that IMM should be included in the differential diagnosis when an abnormal intramuscular lesion concomitant with malignancy is identified. The value of histopathological diagnosis prior to definitive treatment also requires highlighting.

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“…Other metastatic sites as skeletal muscle are extremely rare [1] [2], and there are very few cases described in literature [3] [4]. Some of these muscle metastases are diagnosed only when the autopsy is performed, since they are mostly asymptomatic [5]. Several factors have been proposed to explain the rarity of this type of metastases, such as blood flow in the muscle tissue, the type of cell metabolism, trauma and muscle contraction.…”

Section: Introductionmentioning

confidence: 99%

Abdominal Muscular Metastases of a Pulmonar Adenocarcinoma

Rocha¹,

Brandão²,

Cruz³

et al. 2015

ALC

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Metastases are synonymous of malignant neoplasm in advanced stage and so associated with a poor prognosis. As the first manifestation of cancer disease, the muscle metastasis is very rare. The definitive diagnosis of its presence is made based on histology. The authors presented the case of a patient with a lung adenocarcinoma, being with first manifestation of it, a muscle metastasis only about a month later there were clinical manifestations with imaging appearance that led to the diagnosis of a primary neoplasm. The rare manifestation of the disease motivated the study and surveillance of the patient and lead to the diagnosis.

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Skeletal muscle metastases from lung cancer

Cited by 10 publications

References 5 publications

A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma

A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

Abdominal Muscular Metastases of a Pulmonar Adenocarcinoma

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