Skeletal Muscle Mitochondrial Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction

“…29 Systemic inflammation may also negatively affect endothelial, microvascular, and skeletal muscle structure and function in HFpEF, which may further contribute to impairments in exercise capacity and tolerance. 35 In line with this, patients with higher IL-6 displayed a higher metabolic cost (VO 2 /W) of their peak exercise.…”