Skin Autofluorescence and Complications of Diabetes: Does Ethnic Background or Skin Color Matter?

Ahdi, Mohamed; Gerdes, Victor E. A.; Graaff, Reindert; Kuipers, Saskia; Smit, Andries J.; Meesters, Eelco W.

doi:10.1089/dia.2013.0374

Cited by 13 publications

(14 citation statements)

References 19 publications

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“…The study was approved by the local ethical committee of the Slotervaart Hospital, Amsterdam, the Netherlands. A total of 126 patients from a larger, previously described 33 cohort of patients with type 2 diabetes were included in the study. The cohort was recruited between May 2009 and December 2010 and consisted of patients visiting the Department of Internal Medicine, Slotervaart Hospital, for their annual comprehensive diabetes evaluation.…”

Section: Patientsmentioning

confidence: 99%

“…In addition to UAE and glucose biochemistry, the patients were characterized in terms of plasma lipid profile and serum and urinary creatinine by standard biochemical assays, as described previously. 33 Both blood and urine samples were centrifuged at 2000 Â g to obtain EDTA plasma and urine supernatant, respectively. To characterize normal values for sTAM receptors in body fluids, plasma and urine were collected from 18 healthy volunteers (nonobese, without diabetes mellitus, metabolic syndrome, hypercholesterolemia, hypertension, cardiovascular, or renal disease, age >40 years).…”

Section: Patientsmentioning

confidence: 99%

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Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy

Ochodnický

Lattenist

Ahdi

et al. 2017

The American Journal of Pathology

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TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity. Circulating TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to autoimmune disorders. We investigated TAM and their ligand protein S in patients with diabetes. Urinary and plasma levels of protein S, sTyro3, sAxl, and sMer were determined in 126 patients with diabetes assigned to a normoalbuminuric or macroalbuminuric (urinary albumin excretion <30 mg/24 hours and >300 mg/24 hours, respectively) study group and 18 healthy volunteers. TAM and protein S immunostaining was performed on kidney biopsy specimens from patients with diabetic nephropathy (n = 9) and controls (n = 6). TAM expression and shedding by tubular epithelial cells were investigated by PCR and enzyme-linked immunosorbent assay in an in vitro diabetes model. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer expression in diabetic nephropathy tissue and glomerular depositions of protein S. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer. Renal injury in diabetes is associated with elevated systemic and urine levels of sMer and sTyro3. This is the first study reporting excretion of sTAM receptors in urine, identifying the kidney as a source of sTAM.

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Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy

Ochodnický

Lattenist

Ahdi

et al. 2017

The American Journal of Pathology

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“…Recently, more studies confirmed the positive association between SAF and one or more complications. Four (cross-sectional) studies showed an independent relation between SAF and both micro- and macrovascular complications in T2DM [ 52 – 55 ]. Ahdi et al .…”

Section: Micro - and Macrovascular Complications In Diabetesmentioning

confidence: 99%

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Fokkens

Smit

2016

Glycoconj J

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Glycation is important in the development of complications of diabetes mellitus and may have a central role in the well-described glycaemic memory effect in developing these complications. Skin fluorescence has emerged over the last decade as a non-invasive method for assessing accumulation of advanced glycation endproducts. Skin fluorescence is independently related to micro- and macrovascular complications in both type 1 and type 2 diabetes mellitus and is associated with mortality in type 2 diabetes. The relation between skin fluorescence and cardiovascular disease also extends to other conditions with increased tissue AGE levels, such as renal failure. Besides cardiovascular complications, skin fluorescence has been associated, more recently, with other prevalent conditions in diabetes, such as brain atrophy and depression. Furthermore, skin fluorescence is related to past long-term glycaemic control and clinical markers of cardiovascular disease. This review will discuss the technique of skin fluorescence, its validation as a marker of tissue AGE accumulation, and its use as a clinical tool for the prediction of long-term complications in diabetes mellitus.

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“…Details on the measurement of blood pressure, the routine analysis of blood samples for fasting lipids, glucose, HbA1c, high-sensitivity Creactive protein (hs-CRP), and (micro)albuminuria, and the clinical definitions for diabetes-related microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular complications are described elsewhere [17].…”

Section: Clinical Data Measurements and Definitionsmentioning

confidence: 99%

Oral health information from the dentist to the diabetologist

Ahdi

Teeuw

Meeuwissen

et al. 2015

European Journal of Internal Medicine

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Skin Autofluorescence and Complications of Diabetes: Does Ethnic Background or Skin Color Matter?

Cited by 13 publications

References 19 publications

Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy

Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Oral health information from the dentist to the diabetologist

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