Skin autofluorescence is associated with vascular complications in patients with type 2 diabetes

Osawa, Saeko; Katakami, Naoto; Sato, Ihoko; Ninomiya, Hiroyo; Omori, Kazuo; Yamamoto, Yorimasa; Takahara, Mitsuyoshi; Miyashita, Kazuyuki; Sakamoto, Fumie; Kawamori, Dan; Matsuoka, Taka‐aki; Shimomura, Iichiro

doi:10.1016/j.jdiacomp.2018.06.009

Cited by 22 publications

(27 citation statements)

References 33 publications

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“…The flowchart of this systematic review and meta-analysis is presented in Figure 1 . The search retrieved a total of 90 articles, of which 25 studies [ 12 , 13 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] were selected for inclusion in the systematic review according to the inclusion criteria. Finally, 12 studies evaluating the association between PWv and SAF and 17 studies evaluating the association between C-IMT and SAF were identified and considered in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Evidence exists of the association between AGE levels and different CVD subclinical processes, such as arterial stiffness and atherosclerosis [ 11 , 12 ]. The accumulation of AGEs has been associated with an increase in pulse wave velocity (PWv), which is the gold standard for measuring arterial stiffness [ 13 ], both in healthy adults and individuals with different pathologies, such as patients with coronary heart disease, type 1 or 2 diabetes mellitus, and kidney disease [ 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Saz‐Lara

Álvarez‐Bueno

Martínez‐Vizcaíno

et al. 2020

IJERPH

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Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Saz‐Lara

Álvarez‐Bueno

Martínez‐Vizcaíno

et al. 2020

IJERPH

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show abstract

“…The presence and accumulation of AGEs can be measured by both circulating plasma AGEs or skin AGEs as measured by skin autofluorescence (SAF). The formation of AGEs is thought to be accelerated in chronic hyperglycaemia and oxidative stress [2,3] and as such, it is well known that AGE accumulation is associated with diabetes mellitus (DM) and its complications [1,4,5], including cardiovascular disease (CVD) [6][7][8], renal disease [4,9] and dementia [10,11].…”

Section: Introductionmentioning

confidence: 99%

Measures of lung function and their relationship with advanced glycation end-products

et al. 2020

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BackgroundAdvanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50–64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) and impulse oscillometry (IOS) in relation to SAF.MethodsParticipants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; DLCO, n=3889; IOS, n=3970). Linear regression was used to assess changes in lung function (as measured by spirometry (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC), DLCO and IOS (resistance measured at 5 (R5) and 20 Hz (R20), R5−R20, area of reactance, reactance measured at 5 Hz (X5), and resonant frequency)) by a 1-sd increase in SAF.ResultsFEV1, FVC and DLCO were significantly and inversely associated with SAF after adjustment for potential confounding factors (per 1-sd increase in SAF: FEV1 −0.03 L (95% CI −0.04– −0.02 L), p<0.001; FVC −0.03 L (95% CI −0.05– −0.02 L), p<0.001; DLCO −0.07 mmol·min−1·kPa−1 (95% CI −0.11– −0.03 mmol·min−1·kPa−1), p<0.001). This association was also found in nonsmokers and in non-COPD subjects. Pulmonary reactance (X5) but not pulmonary resistance (R5, R20 and R5−R20) was significantly associated with SAF (per 1-sd increase in SAF: X5 −0.001 kPa·L−1·s (95% CI −0.003–0.00 kPa·L−1·s), p=0.042), which was mirrored in non-COPD patients but not in current nonsmokers.ConclusionsAGE accumulation, as measured by SAF, is significantly associated with lung function decrements indicative of changes in the lung parenchyma

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“…The relations between SAF and these complications, as already reported for T1D [ 20 , 21 ] were therefore expected. Numerous studies have reported high sAF in complicated T2D [ 16 , [22] , [23] , [24] ]. In accordance with our findings, the largest previous study (N = 563) from Noordzij et al.…”

Section: Discussionmentioning

confidence: 99%

Skin autofluorescence, a marker of glucose memory in type 2 diabetes

et al. 2020

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Skin autofluorescence is associated with vascular complications in patients with type 2 diabetes

Cited by 22 publications

References 33 publications

Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Measures of lung function and their relationship with advanced glycation end-products

Skin autofluorescence, a marker of glucose memory in type 2 diabetes

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