Skin Biopsy in the Context of Dermatological Diagnosis: A Retrospective Cohort Study

Korfitis, Chrysovalantis; Gregoriou, Stamatis; Antoniou, Christina; Katsambas, Andreas; Rigopoulos, Dimitrios

doi:10.1155/2014/734906

Cited by 31 publications

(52 citation statements)

References 10 publications

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“…In a Malaysian experience of 400 biopsies, Yap et al recorded a clinicopathological concordance of 86.8% [7]. In a study of 282 cases, Gupta et al found the same to be 85.8% of the cases, whereas a Greek study found the same to be 68% [5,8]. The clinicopathological concordance in our study was found to be 61.01%.…”

Section: Discussionsupporting

confidence: 63%

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Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Malik

Siraj

Sharma

et al. 2020

Cureus

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Introduction To determine the spectrum of diseases and the level of clinicopathological concordance in skin biopsies received over a period of one year. Methods A total of 2216 skin biopsy cases received over a period of one year at a tertiary care center were retrospectively analyzed. The cases were further divided into further categories in levels of concordance based on the agreement between the clinical and histopathological diagnosis rendered. Results Of the cases, 61.01% showed clinicopathological concordance. Cases with a descriptive pathological diagnosis, not matching the clinical diagnosis, constituted 31.54%, whereas 4.02% of cases had a definitive pathological diagnosis, which was discordant with the clinical differentials; 3.29% biopsies were inadequate. Conclusion This study highlights the clinicopathological concordance in all the biopsies received from dermatology. It emphasizes the importance of skin biopsies in arriving at the diagnosis. However, it is a tool that must be used judiciously. Skin biopsies are also pivotal in flagging malignancies that may mimic benign lesions.

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Section: Discussionsupporting

confidence: 63%

“…The histopathological picture depends on a variety of factors that influence the diagnosis; this has been illustrated in various studies. These include the clinical information provided, age of the lesion, technique of the biopsy, and fixation and processing of the tissue amongst others [5].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Malik

Siraj

Sharma

et al. 2020

Cureus

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“…The skin is the most exposed organ to sunlight and other forms environmental hazards (1) . The management of skin diseases requires an accurate diagnosis, which in many instances constitutes a complex process (2) . Skin biopsy is a fundamental investigation in dermatology, where histopathologic finding assists in determining disease pattern as well as morphological correlations (1) .…”

Section: Introductionmentioning

confidence: 99%

“…Skin biopsies are routinely undertaken in the outpatient dermatology setting as a tool to diagnose benign tumors, malignant cancers, and inflammatory skin lesions. They are the link that allows dermatologists and dermatopathologists to participate in the treatment of patients (3) .Dermatologists often depend on skin biopsy for finalizing their diagnostic abilities (2) . Skin diseases are common and may be the cause of considerable morbidity, especially in elderly (1) .…”

Section: Introductionmentioning

confidence: 99%

“…Skin diseases are common and may be the cause of considerable morbidity, especially in elderly (1) . The prevalence of skin diseases varies widely according to various geographical regions and is affected by many factors such as environmental, genetic, dietary, hygiene and others (2) . There are a few published reports on the pattern of skin disease in general, (3)(4)(5)(6) and most, if not all studies which are published are based on clinical studies rather than histopathological ones.…”

Section: Introductionmentioning

confidence: 99%

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Profile of Skin Biopsies and Skin Cancer Subtypes in Hail Region : A Three Years Retrospective Study

Alshammari

Alghaythi

Alharbi

et al. 2018

Egyptian Journal of Hospital Medicine

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Objectives: to analyze the spectrum of skin lesions at our institute, and study the age, sex and anatomic distribution pattern. We will also classify the lesions into major categories and determine the incidence of each subcategory. Materials and Methods: we carried a three and half year's retrospective study of skin biopsies which were collected from King Khalid Hospital recording system in Hail region in a time period from January 2014 till April 2017.Results: The highest percentage was in the age group 30-39 year (25.1%) with a male preponderance of 52.8%. The head, neck and face were most frequently involved body parts (46.06%). Cysts were the most common (32.3%) which included the sub-types epidermoid cyst, ganglion, dermoid cyst, pilar cyst and brachial cleft cyst. Nevi (19.4%) including intradermal nevus, congenital nevus and blue nevus were the second most common skin lesion. Correlation with the histopathologic diagnosis was positive in 94.9% cases and negative in 5.1% cases.

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Dermatoscopy of primary localised cutaneous amyloidosis ‐ A cross‐sectional study in a setting of South Asian public dermatology department

Pudasaini,

Paudel,

et al. 2023

Skin Health and Disease

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BackgroundAmyloidosis, deposition of misfolded protein in body, is a fairly common condition. The deposition of misfolded proteins in skin which occurs in absence of systemic comorbidities, namely Primary Cutaneous Amyloidosis (PCA) is also a well‐known entity in skin of colour patients of Asian subcontinent. Primary Cutaneous Amyloidosis is usually diagnosed with good clinical acumen and typical clinical phenotype and involved site. Dermoscope has been used as an adjunct non‐invasive tool to confirm cases with diagnostic uncertainty and in those in whom biopsy is deferred. Typical dermoscopic features of PCA helps differentiate it from other pigmentary dermatoses and avoids unwanted invasive biopsies and investigations especially in resource poor settings with financial constraints.ObjectivesThis study aims to identify and corroborate clinically, typical dermoscopic features in PCA in 42 patients which includes Macular Amyloidosis (MA) and Papular Amyloidosis (PA) predominantly in skin of colour patients from government based hospital of a south east Asian country.Materials and methodsPatients with classic clinical features of PCA were selected. Primary Cutaneous Amyloidosis was subclassified into MA or PA and their corresponding clinically corroborative dermoscopic features were enlisted respectively. All patients (treatment naïve and previously treated), who consented to participate in the study were included. Patients were diagnosed based on the prototypical clinical features. Dermoscopy was done using DermLite III DL3N Polarised and Fluid Dermoscope w/PigmentBoost Brand (3Gen, DermLite LLC, San Juan Capistrano, CA, USA) and images were obtained to create digital dermoscopy system by attaching camera‐equipped mobile device via an optional connection kit (Redmi Note 11, MIUI version 13.0.5, CHINA) and the findings were enlisted concurrently.ResultsIn this study of dermoscopic findings of PCA, 42 patients were evaluated for their clinical lesions along with its corroboration with the dermoscopic features. Macular Amyloidosis was seen in 30 patients and 12 patients had typical cutaneous phenotypic and dermoscopic feature of PA. The most common dermoscopic finding seen in patients with MA was shiny to dull white, circular or oval central hub surrounded with halo of light brown dots. Most common configuration of brownish pigmentation around central hub was fine streak type. Also eccrine clues were seen in some cases of MA, which was a unique finding. Similarly in the PA subtype, the central hub was replaced by scar like structureless translucent white area surrounded by brownish black dot like structures, especially in those with large and thick plaques.ConclusionDermoscopic findings of PCA and their clinical corroboration is a much‐needed aspect in treating patients with pigmentary disorders and in those with skin of colour, especially in developing countries. Utilization of dermoscope in clinical settings of low income countries and in government based hospitals will decrease the add on economic burden of invasive diagnostic modalities like biopsy and other inadvertent tests done to rule out pigmentary conditions.

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Skin Biopsy in the Context of Dermatological Diagnosis: A Retrospective Cohort Study

Cited by 31 publications

References 10 publications

Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Clinicopathological Concordance in 2216 Cases of Skin Biopsy over One Year: An Indian Experience

Profile of Skin Biopsies and Skin Cancer Subtypes in Hail Region : A Three Years Retrospective Study

Dermatoscopy of primary localised cutaneous amyloidosis ‐ A cross‐sectional study in a setting of South Asian public dermatology department

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