Skin Cancer Identification Using Multifrequency Electrical Impedance—A Potential Screening Tool

Åberg, Peter; Nicander, Ingrid; Hansson, Johan; Geladi, Paul; Holmgren, Ulf; Ollmar, Stig

doi:10.1109/tbme.2004.836523

Cited by 262 publications

(180 citation statements)

References 23 publications

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“…108 Bioimpedance levels are a function of cell shape and structure, cell membranes, and the amount of water present in the cells. Based on these features, electrical impedance of cancer and benign cells are different because cancer cells typically have a different shape, size, and orientation than benign cells do.…”

Section: Cellular Electrical Resistance (Bioimpedance)mentioning

confidence: 99%

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

Rigel

Russak

Friedman

2010

CA: A Cancer Journal for Clinicians

342

274

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Early detection of malignant melanoma remains the key factor in lowering mortality from this cancer. Recognizing the importance of this issue 25 years ago, our group at New York University published in CA: A Cancer Journal for Clinicians the mnemonic "ABCD" to facilitate the early diagnosis of melanoma. Studies have demonstrated the usefulness of this paradigm in enhancing early melanoma diagnosis as a part of clinical examinations, mass screenings, and public education programs. Approaches to melanoma diagnosis have dynamically evolved during the ensuing quarter century. In the 1990s, dermoscopy enabled the recognition of new subsurface features to differentiate between malignant and benign pigmented lesions. During the last decade, new computer-based technologies have improved diagnostic sensitivity and specificity and may result in optimizing lesion selection for biopsy and pathology review. Despite all of the advances in melanoma diagnosis, timely recognition, detection, and rapid treatment of melanoma remain critical. Although pathologic examination remains the gold standard for diagnosis, this cancer has the potential to be diagnosed through noninvasive approaches because of its cutaneous location. From the development of the ABCDs through current attempts that use complex computer algorithms and genetic markers, a clinician's ability to detect melanoma in its earliest form has been augmented. However, a "good clinical eye" is still fundamental to selecting the lesions for evaluation among the sea of those that are prevalent. As current approaches are refined and new techniques are developed, the improved ability to diagnose this cancer will hopefully enhance reaching the goal of reducing melanoma mortality. CA Cancer J Clin 2010;60:301-316.

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Section: Cellular Electrical Resistance (Bioimpedance)mentioning

confidence: 99%

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

Rigel

Russak

Friedman

2010

CA: A Cancer Journal for Clinicians

342

274

View full text Add to dashboard Cite

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“…Electrical Impedance Spectroscopy (EIS) has been widely used to assess the condition of animal tissues, both in vivo, in vitro and ex vivo and for various other applications [2][3][4][5][6][7][8][9][10][11][12][13]. This method is useful to characterize cellular changes quantitatively [5,11,13].…”

Section: Introductionmentioning

confidence: 99%

Electrical impedance spectroscopy study of biological tissues

Dean

Ramanathan

Machado

et al. 2008

Journal of Electrostatics

247

154

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The objective of this study was to investigate the electrical impedance properties of rat lung and other tissues ex vivo using Electrical Impedance Spectroscopy. Rat lungs (both electroporated and naïve (untreated)), and mesenteric vessels (naïve) were harvested from male Sprague-Dawley rats; their electrical impedance were measured using a Solartron 1290 impedance analyzer. Mouse lung and heart samples (naïve) were also studied. The resistance (Real Z, ohm) and the reactance (Im Z, negative ohm)) magnitudes and hence the Cole-Cole (Real Z versus Im Z) plots are different for the electroporated lung and the naive lung. The results confirm the close relationship between the structure and the functional characteristic. These also vary for the different biological tissues studied. The impedance values were higher at low frequencies compared to those at high frequencies. This study is of practical interest for biological applications of electrical pulses, such as electroporation, whose efficacy depends on cell type and its electrical impedance characteristics.

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“…It is used for patient monitoring, diagnosis support and for different types of clinical studies [2] e.g. Impedance pneumography, Skin Cancer Screening [3] and assessment on body composition [4]. Electrical impedance tomography (EIT) aims at producing static or dynamic images related to the conductivity distribution of the measured region [5].…”

Section: Introduction Easurements Of Electrical Bioimpedance (Ebi)mentioning

confidence: 99%

Electrical Bioimpedance Cerebral Monitoring

Martinez¹,

Lindecrantz²

Encyclopedia of Healthcare Information Systems

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-i - A B S T R A C TNeurologically related injuries cause a similar number of deaths as cancer, and brain damage is the second commonest cause of death in the world and probably the leading cause of permanent disability. The devastating effects of most cases of brain damage could be avoided if it were detected and medical treatment initiated in time. The passive electrical properties of biological tissue have been investigated for almost a century and electrical bioimpedance studies in neurology have been performed for more than 50 years. Even considering the extensive efforts dedicated to investigating potential applications of electrical bioimpedance for brain monitoring, especially in the last 20 years, and the specifically acute need for such non-invasive and efficient diagnosis support tools, Electrical Bioimpedance technology has not made the expected breakthrough into clinical application yet. In order to reach this stage in the age of evidence-based medicine, the first essential step is to demonstrate the biophysical basis of the method under study. The present research work confirms that the cell swelling accompanying the hypoxic/ischemic injury mechanism modifies the electrical properties of brain tissue, and shows that by measuring the complex electrical bioimpedance it is possible to detect the changes resulting from brain damage. For the development of a successful monitoring method, after the vital biophysical validation it is critical to have available the proper electrical bioimpedance technology and to implement an efficient protocol of use. Electronic instrumentation is needed for broadband spectroscopy measurements of complex electrical bioimpedance; the selection of the electrode setup is crucial to obtain clinically relevant measurements, and the proper biosignal analysis and processing is the core of the diagnosis support system. This work has focused on all these aspects since they are fundamental for providing the solid medico-technological background necessary to enable the clinical usage of Electrical Bioimpedance for cerebral monitoring.Keywords: Electrical Bioimpedance Spectroscopy, Hypoxia, Ischemia, Stroke, Brain Monitoring, Impedance Measurements, Biomedical Instrumentation, Non-invasive Monitoring.-iiPreface -iii - P R E F A C EThis research work has been performed mainly in collaboration between the following research and academic institutions: the School of Engineering at University College of Borås, the Department of Signals and Systems at Chalmers University of Technology, the Sahlgrenska University Hospital, and the Sahlgrenska Academy at Göteborg University.Specific activities of this research work have been carried out in collaboration with the Department of Electronic Engineering at the Polytechnic University of Catalonia, Spain.This research work has been mainly funded by the Swedish Research Council (Vetenskapsrådet) through a research grant (No. 2002-5487). The research activity performed has also been part of the following European Network of Excellence: "Comp...

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Skin Cancer Identification Using Multifrequency Electrical Impedance—A Potential Screening Tool

Cited by 262 publications

References 23 publications

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

Electrical impedance spectroscopy study of biological tissues

Electrical Bioimpedance Cerebral Monitoring

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