Skin changes in dialysis patients: a review

Skin changes in chronic kidney disease

“…The mechanism underlying their development is not fully understood, however similarly to the pathogenesis of hyperpigmentation, it is suspected to involve an elevated level of MSH [2,3,6,9,16,17]. Clinically, in half-and-half nails the proximal portion of the nail is white, with normal or brown discolouration seen distally [2,6,9,11,16,17]. The disorder is more common on fingernails than toenails [6].…”

“…The disorder is more common on fingernails than toenails [6]. There is no effective treatment modality, however in some patients half-and-half nails have been shown to resolve after kidney transplantation [2,3,6,9,11,17]. Chronic kidney disease may also be accompanied by hypoalbuminaemia manifesting as the so-called Muehrcke's lines, i.e.…”

“…The lesions appear as a white deposit on the skin resulting from the elimination of excess urea by the sweat glands. The symptom has been observed to resolve after the initiation of dialysis treatment [3,9,17].…”

“…Mechanizm ich powstania nie jest znany, chociaż podobnie jak w patogenezie przebarwień podejrzewa się udział podwyższonego stężenia MSH [2,3,6,9,16,17]. Klinicznie zmiany mają postać prawidłowego lub brunatnego zabarwienia dystalnych części paznokci oraz zbielenia części proksymalnych [2,6,9,11,16,17]. Częściej dotyczą płytek paznokciowych rąk niż stóp [6].…”

Dermatological diseases in patients with chronic kidney disease

“…It is caused by reduction in the size of eccrine sweat glands and atrophy of sebaceous glands. Use of diuretics has also been implicated (1,6). Treatment of xerosis involves behavioral changes and use of topicals.…”