Skin dose for head and neck cancer patients treated with intensity-modulated radiation therapy(IMRT)

Fu, Hsiao-Ju; Li, Chi-Wei; Tsai, Wei-Ta; Chang, Chia Ju; Tsang, Yuk-Wah

doi:10.1016/j.radphyschem.2017.02.017

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…The TLD-100H responded linearly to radiation doses from 0.5 to 15 mSv. The conversion factor for the TLD-100H, obtained using the EXCEL linear regression function, was Y(mSv) = −0.768 + 9.978 × TLD (nC), and the square of the correlation coefficient ( R 2 ) was 0.9877 [25].…”

Section: Resultsmentioning

confidence: 99%

“…The regression equation between H E,TLD and the body weight of the examinee, H E,TLD (mSv) = 5.45×10 –3 W (kg)+1.361, has an R 2 of 0.87667. Because the R 2 in linear regression is high, it reveals that TLD is a good approach for evaluating the H E,TLD of PMMA phantoms during brain CT examinations [25, 30]. The H E,TLD value of the Rando phantom was 1.72 ± 0.28 mSv, which was lower than that of the 70 kg phantom, 1.80 ± 0.24 mSv.…”

Section: Resultsmentioning

confidence: 99%

“…This investigation has many limitations, including the following: (i) inherent variation among TLD-100H dosimeters, TLD chip positioning and directionality error; (ii) a lack of published data on conversion factors ( k ) of the new generation of CT scanners (128-slice CT scanners) for adult and pediatric use; (iii) lack of verification of results in clinical practice as TLDs cannot be used in patients for ethical reasons; (iv) limited evaluation of image noise in the quantitative image quality assessment; (v) effect of scanning range on H E,DLP values as a result of allowing a wider beam width in scanning acquisitions [6]; and (vi) inherent uncertainties in the definition of H E,TLD that arise from the use of an approximate W T , averaged over a population. Despite their limitations, TLDs remain the most practically useful devices for obtaining D T and H T values for medical procedures [25].…”

Section: Resultsmentioning

confidence: 99%

“…The phantom comprised a human skeleton that was embedded in the anthropomorphic material. The specified densities of the components of the anthropomorphic phantom were 0.98 g cm −3 for the soft tissue, 2.70 g cm −3 for the skeleton and 0.32 g cm −3 for the lungs [25]. Anthropometrically shaped skeletons, constructed from epoxy-resin and PMMA, were used to simulate humans [26].…”

Section: Methodsmentioning

confidence: 99%

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Radiation doses with various body weights of phantoms in brain 128-slice MDCT examination

Lin

Lai

Tseng

et al. 2019

Journal of Radiation Research

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The effective dose (HE) and organ or tissue equivalent dose (HT) for use in brain computed tomography (CT) examinations with various body weights were evaluated. Thermoluminescent dosimeters (TLD-100H) were inserted into Rando and five anthropomorphic phantoms. These phantoms were made of polymethylmethacrylate (PMMA), according to the specifications of ICRU 48, with masses from 10 to 90 kg. Brain CT examinations were conducted, scanning the maxillae from the external auditory meatus to the parietal bone using a 128-slice multi-detector CT (MDCT) scanner. To reduce errors, three independent trials were conducted. Calculated HE,TLD, based on the weighting factor recommended by ICRP 103, was 1.72 ± 0.28 mSv, which slightly exceeds the HE,DLP of 1.70 mSv, that was calculated from the dose–length product (DLP) of the Rando phantom. This experiment yielded HE,TLD values of ICRP 103 from the highest 1.85 ± 0.28 (90 kg) to the lowest 1.47 ± 0.22 (10 kg) mSv. HE,TLD (mSv) = 5.45×10−3 W(kg) + 1.361, with an R2 of 0.87667. Using the DLP protocol, HE,DLP was estimated from CTDIvol that was recorded directly from the console display of the CT unit and multiplied by the conversion coefficient (k) recommended by the ICRP 103. Finally, the experimental results obtained herein are compared with those in the literature. Physicians should choose and adjust protocols to prevent the exposure of patients to unnecessary radiation, satisfying the as low as reasonably achievable (ALARA) principle. These findings will be valuable to patients, physicians, radiologists and the public.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Radiation doses with various body weights of phantoms in brain 128-slice MDCT examination

Lin

Lai

Tseng

et al. 2019

Journal of Radiation Research

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“…In NPC treatments, skin reactions remain a concern [6][7][8][9] as they can seriously affect the patients' quality of life. Their acute effect is observed within days after irradiation and results from damage to the epidermis (0.03-0.3 mm thick).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a Skin Dose Reduction for Nasopharyngeal Carcinoma Treated With High-Intensity-Modulated Delivery Techniques

Liao

Wang

et al. 2018

Technol Cancer Res Treat

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Acute skin toxicity observed in radiotherapy treatment of head and neck cancer is a big concern. The purpose of this work is to evaluate the feasibility of a skin dose reduction in the treatment of nasopharyngeal carcinoma without compromising the overall plan quality. This research focused on comparison of the skin dose reduction that can be obtained for the main high conformal radiotherapy delivery techniques. Sixteen cases of early-stage nasopharyngeal carcinoma were included in this study. For each case, a dynamic intensity-modulated radiation therapy, a volumetric modulated arc therapy, and a helical tomotherapy treatment plans were performed with and without the skin as a sensitive structure in the inverse plan optimization. The dosimetric results obtained for the different treatment techniques and plan optimizations were compared. Dose–volume histogram cutoff points of D95%, D98%, and the homogeneity index were used for target comparison, while Dmean and Dmax/D1cc were used for the organs at risk. The skin volume receiving 5 Gy and then 10 to 70 Gy of radiation dosage registered at step of 10 Gy and Dmean were used for the skin dose comparison. One-way analysis of variance was used to assess the dosimetric results obtained for the different types of treatment plans and techniques investigated. A total of 96 treatment plans were analyzed. When the neck skin was considered in the treatment optimization process, the skin volume that received more than 30 Gy was reduced by 3.7% for dynamic intensity modulated, 4.1% for volumetric modulated arc, and 4.3% for dynamic intensity modulated, while the target dose coverage and organs at risk dosages remained unvaried (p > .05).

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Monitoring skin dose changes during image-guided helical tomotherapy for head and neck cancer patients

et al. 2019

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Skin dose for head and neck cancer patients treated with intensity-modulated radiation therapy(IMRT)

Cited by 8 publications

References 11 publications

Radiation doses with various body weights of phantoms in brain 128-slice MDCT examination

Radiation doses with various body weights of phantoms in brain 128-slice MDCT examination

Feasibility of a Skin Dose Reduction for Nasopharyngeal Carcinoma Treated With High-Intensity-Modulated Delivery Techniques

Monitoring skin dose changes during image-guided helical tomotherapy for head and neck cancer patients

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