Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

Abstract

Gadolinium retention in skin following formulated gadodiamide administration was located to the collagen fibril, in both the extracellular matrix and within activated fibroblasts.

Nephrogenic Systemic Fibrosis and Gadolinium-Based Contrast Media

“…Gadolinium was detected extracellularly around segments of the collagen fibrils and intracellularly within fragments of collagen fibrils in fibroblasts and in histiocytes (Haylor et al 2012). In rats given the same doses of gadoterate no gadolinium was detected within skin collagen fibrils or fibroblasts and there were no skin changes similar to NSF.…”

“…In rats given the same doses of gadoterate no gadolinium was detected within skin collagen fibrils or fibroblasts and there were no skin changes similar to NSF. Bone, liver, and kidney were also examined and the greatest difference between gadodiamide and gadoterate was in the skin, where the concentration of gadolinium was 40 times greater with gadodiamide than with gadoterate (Haylor et al 2012). …”

Distribution profile of gadolinium in gadolinium chelate-treated renally-impaired rats: Role of pharmaceutical formulation

“…Most non-clinical and clinical studies available to date favour a causal role of dissociated Gd in tissues in the pathogenesis of NSF (Abraham et al, 2008;Fretellier et al, 2011bFretellier et al, , 2012Fretellier et al, , 2013Haylor et al, 2012;Idée et al, 2014;Pietsch et al, 2009;Sieber et al, 2008a,b,c;Wadas et al, 2010), although this hypothesis remains disputed by some authors (Grant et al, 2009;Wermuth and Jimenez, 2014). Basically, GCs differ in their ability to release dissociated Gd, with macrocyclic GCs being kinetically more stable than linear agents and linear ionic compounds being thermodynamically more stable than linear non-ionic GCs (Port et al, 2008).…”

Manganese-containing Prussian blue nanoparticles for imaging of pediatric brain tumors

“…We use manganese ions in the nanoparticles to mitigate safety concerns associated with gadolinium ions (Gd 3+ , typically used in commercial contrast agents) that have been linked to nephrogenic systemic fibrosis in patients with impaired renal function. [27][28][29][30] The Prussian blue nanoparticle core is coated with fluorescently labeled avidin as previously described. 31 The avidin coating biofunctionalizes the nanoparticle and serves as a platform for attaching biotinylated ligands for tumor targeting.…”