Skin microbiome attributes associate with biophysical skin aging

Zhou, Wei; Fleming, Elizabeth; Legendre, Guylaine; Roux, Lauriane; Latreille, Julie; Gendronneau, Gaëlle; Forestier, Sandra; Oh, Julia

doi:10.1101/2023.01.30.526239

Cited by 3 publications

(6 citation statements)

References 56 publications

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“…21 The microbiome plays a role in aging as well. 3 Centenarians have higher levels of Lactobacillus and additionally, Lactobacillus present on skin reduces with age. 2 This study supports the notion of putting LAB back on aging skin to alleviate the skin aging phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…The microbiome plays a role in aging as well 3 . Centenarians have higher levels of Lactobacillus and additionally, Lactobacillus present on skin reduces with age 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Visually, it results in the skin becoming less firm, wrinkles and spots appear and get more prominent, the skin loses its youthful glow, and the skin microbiota changes. [1][2][3] Wrinkles and pores become more prominent due to the weakening of extracellular matrix proteins, such as collagen and elastin fibers. 4 Dullness and dry skin increase because of depleted moisture levels and lowered sebocyte activity, as well as reduced cell turnover and increased senescence.…”

Section: Introductionmentioning

confidence: 99%

“…Skin aging is a complex, albeit unavoidable, process. Visually, it results in the skin becoming less firm, wrinkles and spots appear and get more prominent, the skin loses its youthful glow, and the skin microbiota changes 1–3 . Wrinkles and pores become more prominent due to the weakening of extracellular matrix proteins, such as collagen and elastin fibers 4 .…”

Section: Introductionmentioning

confidence: 99%

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A proof of concept: Clinical anti‐aging efficacy and safety of Lactiplantibacillus plantarumLB244R® applied topically in a double‐blinded placebo‐controlled study

Elvebakken,

Christensen,

Vedel

et al. 2024

J of Cosmetic Dermatology

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BackgroundWith the increasing age of the westernized population, there is also increasing economic and aesthetic interest in reducing the signs of skin aging. Additionally, the physical aspect of aging can be displeasing and have detrimental effects psychologically in individuals. Probiotics have shown potential as anti‐aging agents, albeit proper studies are needed to confirm their potential.AimsProving that Lactiplantibacillus plantarum LB244R® could alleviate aging signs relative to its placebo vehicle.Patients/MethodsIn total, 46 subjects were randomly assigned either the ointment with live bacteria, L. plantarum LB244R® or its vehicle ointment, and had to use the assigned ointment twice daily for 56 days. On Day 0, Day 28, and Day 56 subepidermal low echogenic band (SLEB) thickness, dermal density, skin firmness and elasticity, skin hydration, transepidermal water loss (TEWL), skin pH, collagen fiber visualization using confocal microscopy, Crow's feet, spot score, skin smoothness, and complexion radiance were assessed by dermatologists.ResultsAll parameters except TEWL improved relative to their baseline (D0) for the active group. L. plantarum LB244R® improved SLEB thickness, dermal density, skin elasticity, skin hydration, and Crow's feet wrinkle score relative to the placebo vehicle ointment.ConclusionThe study demonstrates an anti‐aging effect of L. plantarum LB244R® for topical skin use in the first double‐blinded, vehicle‐ointment placebo‐controlled clinical study.

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Section: Discussionmentioning

confidence: 99%

“…The microbiome plays a role in aging as well 3 . Centenarians have higher levels of Lactobacillus and additionally, Lactobacillus present on skin reduces with age 2 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A proof of concept: Clinical anti‐aging efficacy and safety of Lactiplantibacillus plantarumLB244R® applied topically in a double‐blinded placebo‐controlled study

Elvebakken,

Christensen,

Vedel

et al. 2024

J of Cosmetic Dermatology

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“…The composition of the skin microbiome varies throughout life, with aged skin having increased overall diversity. Ageing is further correlated to increased antimicrobial production and physiological reductions in the production of cutaneous factors, notably reduced collagen and sebum [ 40 , 234 ].…”

Section: Skin Microbiome Applications In Personal Care Productsmentioning

confidence: 99%

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Nicholas-Haizelden,

Murphy,

Hoptroff

et al. 2023

Microorganisms

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Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability.

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Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis

Zhou,

Ring,

Caldwell

et al. 2024

Preprint

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Monogenic skin disorders such as ichthyosis introduce multiple sources of disturbance to the skin, including the direct biochemical consequences of the genotype, the phenotypic changes in skin physiology, and an altered skin microbiome. The association between changes in the skin microbiome and the disease's genotypic and phenotypic effects are of both ecological and clinical interest but are historically obscured by 1) the limited resolution of metagenomic profiles, and 2) additional sources of variation such as age and topical/oral treatments. Here we characterize the skin microbiome from seven ichthyosis genotypes, at species, strain, and metabolic pathway levels. Critically, we assess the association between these microbiome features and the ichthyosis genotype and phenotype while adjusting for contextual host covariables. We show that the ichthyosis genotype, especially that caused by mutations in TGM1, and the ichthyosis phenotype, particularly transepidermal water loss (TEWL), and personal covariables, such as topical emollients and oral retinoids, collectively, and sometimes antagonistically, influence the species community, strain population, and metabolic potential of the skin microbiome.

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Skin microbiome attributes associate with biophysical skin aging

Cited by 3 publications

References 56 publications

A proof of concept: Clinical anti‐aging efficacy and safety of Lactiplantibacillus plantarumLB244R® applied topically in a double‐blinded placebo‐controlled study

A proof of concept: Clinical anti‐aging efficacy and safety of Lactiplantibacillus plantarumLB244R® applied topically in a double‐blinded placebo‐controlled study

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis

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