Skin microdialysis coupled with Laser Speckle Contrast Imaging to assess microvascular reactivity

The contribution of sensory nerves to cutaneous vasodilatation of the forearm and leg to local skin heating

“…Our three prior studies used microdialysis fibres to intradermally administer pharmacological agents. While it has been reported that ~90 min is sufficient time to allow for needle insertion trauma to subside in the skin of the forearm following microdialysis fibre placement (Cracowski et al 2011;Anderson et al 1994;Hodges et al 2009), this might not be sufficient for the skin of the leg, resulting in our previously reported higher basal CVC. However, this is unlikely as others have used microdialysis fibres in the legs and reported no such differences in LDF or CVC (Yamazaki and Yuge 2011) or power spectra (Stewart et al 2007).…”

Assessment of Skin Microvascular Function and Dysfunction With Laser Speckle Contrast Imaging

“…3,8,54 This method is based on the use of fibers with a semipermeable membrane at the fiber tip. The fiber, which is implanted in the skin in the interstitial space, is continuously perfused with a physiological solution.…”

Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing

“…It has been becoming a fascinating tool to assess the cutaneous blood flow dynamics [18][19][20][21][22]. However, the turbid skin-induced static speckles conceals the dynamic information of the blood flow and reduces the imaging resolution and contrast, that makes it difficult to sensitively monitor the cutaneous blood flow dynamical response [23].…”