Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Manasa, G.; Mascarenhas, Ronald J.; Shetti, Nagaraj P.; Malode, Shweta J.; Mishra, Amit; Basu, Soumen; Aminabhavi, Tejraj M.

doi:10.1021/acsabm.1c01289

Cited by 42 publications

(23 citation statements)

References 190 publications

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“…Biosensors based on silk fibroin and their derivatives also attract great interest due to their ability to detect various small biomolecules, including biochemicals, proteins, electrolytes, and disease-specific genes. 98,99 The abundant functional groups in SF polymer chains, together with the complexity of physical interaction between molecules, can serve as excellent targets for the designing of novel detection systems for diverse diagnostic applications. 100 For example, various enzymes and aptamers can target the SF molecular chain by functional groups amino and hydroxyl, which improve their stability in the detection systems.…”

Section: Methodsmentioning

confidence: 99%

Silk‐based conductive materials for smart biointerfaces

2023

Smart Medicine

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Silk-based conductive materials are widely used in biointerface applications, such as artificial epidermal sensors, soft and implantable bioelectronics, and tissue/cell scaffolds. Such biointerface materials require coordinated physicochemical, biological, and mechanical properties to meet current practical needs and future sophisticated demands. However, it remains a challenge to formulate silk-based advanced materials with high electrical conductivity, good biocompatibility, mechanical robustness, and in some cases, tissue adhesion ability without compromising other physicochemical properties. In this review, we highlight recent progress in the development of functional conductive silk-based advanced materials with different morphologies. Then, we reviewed the advanced paradigms of these silk materials applied as wearable flexible sensors, implantable electronics, and tissue/cell engineering with perspectives on the application challenges. Silk-based conductive materials can serve as promising building blocks for biomedical devices in personalized healthcare and other fields of bioengineering.

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Section: Methodsmentioning

confidence: 99%

Silk‐based conductive materials for smart biointerfaces

2023

Smart Medicine

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“…Most of the non-invasive sensors are enzymatic sensors, while few are non-enzymatic. Much effort has been devoted to the fabrication and functionalization of the requisite sensors for obtaining improved sensitivity [ 107 ].…”

Section: Nanomaterials Integrated Wearable Electrochemical Sensors@ N...mentioning

confidence: 99%

Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

2023

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Sweat contains a broad range of important biomarkers, which may be beneficial for acquiring non-invasive biochemical information on human health status. Therefore, highly selective and sensitive electrochemical nanosensors for the non-invasive detection of sweat metabolites have turned into a flourishing contender in the frontier of disease diagnosis. A large surface area, excellent electrocatalytic behavior and conductive properties make nanomaterials promising sensor materials for target-specific detection. Carbon-based nanomaterials (e.g., CNT, carbon quantum dots, and graphene), noble metals (e.g., Au and Pt), and metal oxide nanomaterials (e.g., ZnO, MnO2, and NiO) are widely used for modifying the working electrodes of electrochemical sensors, which may then be further functionalized with requisite enzymes for targeted detection. In the present review, recent developments (2018–2022) of electrochemical nanosensors by both enzymatic as well as non-enzymatic sensors for the effectual detection of sweat metabolites (e.g., glucose, ascorbic acid, lactate, urea/uric acid, ethanol and drug metabolites) have been comprehensively reviewed. Along with this, electrochemical sensing principles, including potentiometry, amperometry, CV, DPV, SWV and EIS have been briefly presented in the present review for a conceptual understanding of the sensing mechanisms. The detection thresholds (in the range of mM–nM), sensitivities, linear dynamic ranges and sensing modalities have also been properly addressed for a systematic understanding of the judicious design of more effective sensors. One step ahead, in the present review, current trends of flexible wearable electrochemical sensors in the form of eyeglasses, tattoos, gloves, patches, headbands, wrist bands, etc., have also been briefly summarized, which are beneficial for on-body in situ measurement of the targeted sweat metabolites. On-body monitoring of sweat metabolites via wireless data transmission has also been addressed. Finally, the gaps in the ongoing research endeavors, unmet challenges, outlooks and future prospects have also been discussed for the development of advanced non-invasive self-health-care-monitoring devices in the near future.

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“…High blood sugar is a disease, but if monitored regularly, the chronic effects can be mitigated. Patchables are playing a very key role in achieving this [ 54 ]. A very promising study has been carried out on measuring the effects of ultra-violet radiations on the body using patchables [ 55 ].…”

Section: Wban Technical Issuesmentioning

confidence: 99%

A Survey on Wireless Wearable Body Area Networks: A Perspective of Technology and Economy

Bhatti

Saleem

Imran

et al. 2022

Sensors

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The deployment of wearable or body-worn devices is increasing rapidly, and thus researchers’ interests mainly include technical and economical issues, such as networking, interoperability, security, power optimization, business growth and regulation. To address these issues properly, previous survey papers usually focused on describing the wireless body area network architecture and network protocols. This implies that deployment issues and awareness issues of wearable and BAN devices are not emphasized in previous work. To defeat this problem, in this study, we have focused on feasibility, limitations, and security concerns in wireless body area networks. In the aspect of the economy, we have focused on the compound annual growth rate of these devices in the global market, different regulations of wearable/wireless body area network devices in different regions and countries of the world and feasible research projects for wireless body area networks. In addition, this study focuses on the domain of devices that are equally important to physicians, sportsmen, trainers and coaches, computer scientists, engineers, and investors. The outcomes of this study relating to physicians, fitness trainers and coaches indicate that the use of these devices means they would be able to treat their clients in a more effective way. The study also converges the focus of businessmen on the Annual Growth Rate (CAGR) and provides manufacturers and vendors with information about different regulatory bodies that are monitoring and regulating WBAN devices. Therefore, by providing deployment issues in the aspects of technology and economy at the same time, we believe that this survey can serve as a preliminary material that will lead to more advancements and improvements in deployment in the area of wearable wireless body area networks. Finally, we present open issues and further research direction in the area of wireless body area networks.

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Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Cited by 42 publications

References 190 publications

Silk‐based conductive materials for smart biointerfaces

Silk‐based conductive materials for smart biointerfaces

Electrochemical Nanosensors for Sensitization of Sweat Metabolites: From Concept Mapping to Personalized Health Monitoring

A Survey on Wireless Wearable Body Area Networks: A Perspective of Technology and Economy

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