Skin penetration and deposition of carboxyfluorescein and temoporfin from different lipid vesicular systems: In vitro study with finite and infinite dosage application

Chen, Ming; Liu, Xiangli; Fahr, Alfred

doi:10.1016/j.ijpharm.2011.02.006

Cited by 151 publications

(102 citation statements)

References 47 publications

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“…Shen et al found that the transethosomes prepared by either Lipoid S100 or SPC50 were smaller than those produced by Lipoid E80, and the phospholipids with higher phosphatidylcholine content led to the production of stabler vesicles. 27 Highly negatively charged vesicles were produced by the incorporation of DPPG (1,2-dipalmitoyl-sn-glycero-3-phosphatidylglycerol) in the ethosomal formulation, 48 while cationic ethosomal vesicles were produced by using a cationic lipid, such as DOTAP (1,2-dioleoyl-3-trimethylammonium-propane [chloride salt]). 22 In general, the concentration range of phospholipids in an ethosomal formulation is 0.5%-5%.…”

Section: Phospholipidsmentioning

confidence: 99%

“…Gu et al reported that the mean sizes of 5-fluorouracil ethosomes extruded through membranes with pore sizes of 50 nm and 100 nm were 60±10 nm and 110 ±13 nm, respectively. 93 Many commercially available extruders are used for the extrusion process, such as the Lipex ® extruder (Transferra Nanosciences, Burnaby, BC, Canada), a hand extruder (EMD Millipore, Billerica, MA, USA), 65 the Gastight 1001 extruder (Hamilton, Reno, NV, USA), 48 the Mini-Extruder (Avanti Polar Lipids, Alabaster, AL, USA), 94 and disposable filters. 80 The selection of membrane type, pore size, pressure, number of extrusions, filtration times, or cycles should be optimized according to the required properties of the ethosomal system.…”

mentioning

confidence: 99%

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Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

327

215

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Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

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Section: Phospholipidsmentioning

confidence: 99%

mentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

327

215

View full text Add to dashboard Cite

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“…Several formulation approaches have been adopted to overcome permeation problem associated with penetration enhancers. One possibility for increasing drug permeation across the skin is the use of vesicular carrier system 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Comparative Anti-inflammatory Potential of Crystalline and Amorphous Nano Curcumin in Topical Drug Delivery

Alrohaimi

2015

J. Oleo Sci.

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“…These results supported the acceptance of reconstructed human epidermis models as alternatives to human and pig skin, for the in vitro assessment of the permeation and penetration of substances from aqueous solutions [62,63]. Furthermore, Ulrich Schaefer established a fruitful collaboration with Alfred Fahr the chair of Pharmaceutical Technology at the University in Jena (Germany) who concentrates his research on the development of vesicular drug delivery systems [64,65]. …”

Section: Saarbruecken (Germany): Helmut Loth Ulrich Schaefer Claus-mentioning

confidence: 63%

From the Structure of the Skin Barrier and Dermal Formulations to in vitro Transport Models for Skin Absorption: Skin Research in the Netherlands and in Germany

Windbergs

Hansen²,

Schroeter

et al. 2013

Skin Pharmacol Physiol

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This review presents an overview of German and Dutch research institutions and their studies in the field of skin drug delivery and adjacent topics. In the Netherlands, the involved research groups are mainly localized in Leiden, whereas in Germany the skin research institutions are spread over the whole country. The scientific studies in the Netherlands focus on the in-depth analysis of human skin composition and its individual components as well as on the development and characterization of dermal drug delivery systems ranging from liquid crystalline systems and vesicles up to microneedles with an emphasis on examining the interactions of these drug delivery systems with the human skin in vitro and in vivo. In Germany, the individual areas of research span from in-depth investigations on various drug delivery systems intended for skin application and the development of novel in vitro models for skin absorption testing up to in vivo studies focusing on the biological performance of topically applied actives. Furthermore, sophisticated analytical techniques are applied for the elucidation of skin assembly and transport processes. In addition, experimentally derived data are correlated with advanced computational modelling. Even though the individual research topics in the Netherlands and Germany are quite diverse, the exchange of knowledge and interdisciplinary collaborations between the two neighbouring countries were and are still frequently made. In this context, the review aims at highlighting crosslinks between the different institutions and individual persons to complete the picture. For each institution, the principal investigators and their studies are presented and the upcoming young scientists are introduced as an outlook for the field. This review does not claim completeness, but is rather intended to give a general overview of Dutch and German research in the field of skin drug delivery and adjacent topics.

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Skin penetration and deposition of carboxyfluorescein and temoporfin from different lipid vesicular systems: In vitro study with finite and infinite dosage application

Cited by 151 publications

References 47 publications

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Comparative Anti-inflammatory Potential of Crystalline and Amorphous Nano Curcumin in Topical Drug Delivery

From the Structure of the Skin Barrier and Dermal Formulations to in vitro Transport Models for Skin Absorption: Skin Research in the Netherlands and in Germany

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