Skin sensitivity to denture base materials in the burning mouth syndrome

Abstract

The significance of sensitizing compounds in the denture base for the etiology of the burning mouth syndrome (BMS) has been studied in 53 denture-wearing persons, seven males and 46 females. Epicutaneous patch tests were performed with standard concentrations of benzoyl peroxide, dibutylphthalate, dimethyl-p-toluidine, formaldehyde, hydroquinone, methylmethacrylate, p-phenylendiamine and with cadmium sulfate, potassium dichromate, cobalt chloride and nickel sulfate. Furthermore, patch testing was performed with filings from the denture mixed with the patient's own saliva. In cases with an inflamed oral mucosa, the presence of hyphae of Candida albicans was assessed by a smear technique. Positive skin reactions were observed in 15 persons to dimethyl-p-toluidine, hydroquinone, formaldehyde, methylmethacrylate, p-phenylendiamine, potassium dichromate, cobalt chloride and nickel sulfate, including three cases with reactions to filings from their dentures, and one patient who after subsequent testing showed skin sensitivity to balsam of Peru. In 12 cases an etiological connection could be traced between the oral symptoms and the denture base, indicating that contact sensitivity to base materials or to allergens and microbial antigens on the denture plate plays a greater role in the pathogenesis of BMS in edentulous persons than previously suggested.

HPLC Analysis of Toxic Additives and Residual Monomer from Dental Plate

“…Potential to oral mucosa irritation was small (10)(11)(12)(13)(14). MMA, BPO and DMPT were reported to be allergen (1 5,16).…”

Anxiolytics, Antidepressants and Autogenous training in the therapy of burning mouth syndrome

“…Their results were positive as far as stomatopyrosis is concerned.Glass et al (46) believe that some drugs cause stomatopyrosis, such as tricyclic antidepressants, phenodiazepine, benzodiazepine derivatives, Monoamine oxidaze (MAO) inhibitor and antihistamines. Maresky et al (41) confirmed that the intake of some drugs results in the reduction of salivation, which facilitates the burning sensation.…”

“…Local etiological factors are various stimuli which can be found in the oral cavity.These are: mechanic irritation of oral mucosa and dental treatment against mechanical irritations, particularly problems with mobile dentures, followed by infections of the mouth of bacterial or fungal etiology, dysfunctional TMJ and disorders in the function of the salivary glands.Nater et al (39) established that people suffering from stomatopyrosis have more candidae and coli bacteria than the ones in the control group, where stomatopyrosis wasn't present.Katz et al (40) concluded that infections by fusospyrochetes are more common with people suffering from stomatopyrosis.Maresky et al (41) concluded that people with stomatopyrosis often suffer from gingivitis and periodontitis.…”

Mundtrockenheit und Mundschleimhautbrennen

“…Eine fehlerhafte Zahnprothese (Sitz, Okklusion,Stabilität),eine Allergie gegen Prothesenmaterialien (Methylmethacrylate, Hydrochinon, Dimethyl-p-toluidin, Benzoylperoxid, Dibuthylphtalat, p-Phenylendiamin, Formaldehyd sowie eine Reihe von Metallverbindungen), Kandidainfektionen bei Immunschwäche oder eine mangelhafte Mundhygiene können eine Prothesenstomatitis zur Folge haben [31,40].Die Therapie der Wahl besteht neben symptomatischen Maßnahmen (s. oben) in der Beseitigung der zugrunde liegenden Ursachen.…”