Skin thickness in neonates: Implications for intradermal vaccination

Saitoh, Akihiko; Nirei, Jun; Tanaka, Takeshi; Haniu, Hisanori; Sakai, Tadashi; Okubo, Soichiro; Hirano, Harunobu

doi:10.1016/j.vaccine.2020.06.061

Cited by 3 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent milestones in skin development are the appearance of rete ridges in the 30 th week of gestation and the generalization of basketweave keratin at approximately the 28 th week of gestation. All layers of the skin become thicker with gestational age, which has been shown by both autopsy and ultrasonographic (USG) methods [ 32 , 33 ]. The comparison of preterm and term-born patients’ skin on ultrasound images is shown in Figure 2 (own, unpublished data).…”

Section: Premature Skin and Risk Of Admentioning

confidence: 99%

“…According to the current state of knowledge, interleukin-25 (IL-25), interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are present in skin with an impaired barrier and are responsible for enhancing type 2 inflammation and the overproduction of Th2-profile interleukin-4 (IL-4) Table 3. Differences in preterm and term-born patients' skin, based on the studies of Saitoh et al [33], Visscher et al [31] and interleukin-13 (IL-13) [22,44]. Additionally, CCL (CC chemokine ligand), CCL17, CCL18, CCL22 and CCL26, chemokines related to IL-4 and IL-13, are also overexpressed in the affected skin in patients with AD [45].…”

Section: Inflammation and Cytokine Imbalancementioning

confidence: 99%

See 1 more Smart Citation

Atopic dermatitis and gestational age – is there an association between them? A review of the literature and an analysis of pathology

Kowalik¹,

Cichocka‐Jarosz²,

Kwinta³

2023

pdia

View full text Add to dashboard Cite

Introduction The connection between prematurity and atopic dermatitis (AD) is an intensively investigated topic with existing knowledge gaps. The last review with a meta-analysis in this field was published in 2018. Since then, there have been great advances in the comprehension of AD pathophysiology. Aim To update the knowledge and to discuss the recent findings in the field of AD and its association with prematurity in light of the newest publications. Material and methods An electronic search of Medline was conducted, limited to the last eleven years. The screening of the full version of English articles was performed to ensure the fulfilment of the selection criteria. Results Thirteen articles met the inclusion criteria, with a total of over 4 million participants. In the majority of the studies ( n = 8), prematurity was associated with a lower risk of atopic dermatitis, although there were also publications ( n = 5) that did not find an association between these factors. Conclusions According to this study, prematurity is associated with a lower risk of atopic dermatitis.

show abstract

Section: Premature Skin and Risk Of Admentioning

confidence: 99%

Section: Inflammation and Cytokine Imbalancementioning

confidence: 99%

Atopic dermatitis and gestational age – is there an association between them? A review of the literature and an analysis of pathology

Kowalik¹,

Cichocka‐Jarosz²,

Kwinta³

2023

pdia

View full text Add to dashboard Cite

show abstract

“…The difference between the median TSH values of the disinfectant groups was greater at lower gestational ages, whereas those of the term infants were alike. This may be attributed to the greater absorption capability of preterm infants' thin, immature skin 6 …”

Section: Discussionmentioning

confidence: 99%

“…Hakan Kucuker 1 | Salih Cagri Cakir 2 | Nilgun Koksal 2 | Hilal Ozkan 2 | Fatma Kocael 2 | Bayram Ali Dorum 2 | Cansu Sivrikaya Yildirim 2 | Solmaz Celebi 3 | Mustafa Hacimustafaoglu 3 Free iodine can easily be absorbed from the skin of neonates, especially from those of preterm babies; this has been attributed to the thin and immature skin layer of neonates. 6 As neonates exposed to PVP-I solution are more vulnerable to iodine-induced hypothyroidism, an alternative disinfectant for neonatal care is essential. Chlorhexidine-based antiseptics have been used for general disinfection since 1957 and are effective against gram-positive and gram-negative bacteria and fungi.…”

Section: O R I G I N a L A R T I C L E A Comparison Of Chlorhexidine ...mentioning

confidence: 99%

“…As identified by Wolff and Chaikoff in 1948, excess amounts of iodine in the circulation diminishes the rate of iodine transportation and organification in the thyrocytes 5 . Free iodine can easily be absorbed from the skin of neonates, especially from those of preterm babies; this has been attributed to the thin and immature skin layer of neonates 6 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A comparison of chlorhexidine and povidone‐iodine solutions in neonatal intensive care units

Küçüker

Çakır

Köksal

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

BackgroundPovidone‐iodine (10%; PI) and 2% chlorhexidine in 70% isopropyl alcohol (CHG‐IA) solutions are among the most widely used disinfectants in the neonatal intensive care units. This study compares the use of these disinfectants and helps decide which is superior to the other for neonatal use.MethodsAll term and preterm infants born and hospitalized in Bursa Uludag University Hospital between July 2018–March 2020 were included. The infants were randomized into two disinfectant groups before birth. The application site was cleaned with the assigned disinfectant before intervention. The infants were screened for rates of neonatal sepsis, thyroid‐stimulating hormone (TSH) levels, free thyroxine (fT4) levels, skin reactions to the assigned solution, and acute neurological side effects.ResultsWe enrolled 208 term and preterm infants (PI:104 vs. CHG‐IA: 104) in the study. The prematurity rates were identical (PI: 74.0%; CHG‐IA: 72.1%; p = 0.755). Neonatal sepsis rates among these groups were not statistically different (PI: 8.7%; CHG‐IA: 4.8%; p = 0.406). The median TSH value of the PI group was high (4.05 mIU/L) in comparison with that of the CHG‐IA group (3.09 mIU/L; p = 0.016). No cutaneous or neurological side effects were recorded in patients treated with CHG‐IA solution.ConclusionsAlthough these two solutions were equally protective against infections, the CHG‐IA solution was a better alternative to PI for neonatal use. Considering that the PI solution may be responsible for impaired thyroid function, the CHG‐IA solution is a good alternative because it provides sufficient protection with a safer adverse effect profile.

show abstract

Deep learning enabled in vitro predicting biological tissue thickness using force measurement device

Hu,

Tan,

2024

Computers in Biology and Medicine

View full text Add to dashboard Cite

Skin thickness in neonates: Implications for intradermal vaccination

Cited by 3 publications

References 25 publications

Atopic dermatitis and gestational age – is there an association between them? A review of the literature and an analysis of pathology

Atopic dermatitis and gestational age – is there an association between them? A review of the literature and an analysis of pathology

A comparison of chlorhexidine and povidone‐iodine solutions in neonatal intensive care units

Deep learning enabled in vitro predicting biological tissue thickness using force measurement device

Contact Info

Product

Resources

About