Skin Tissue Engineering in Severe Burns: A Review on Its Therapeutic Applications

Chua, Alvin Wen Choong; Saphira, Chairani Fitri; Chong, Si Jack

doi:10.1007/978-3-030-19962-3_9

Cited by 2 publications

(2 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most important advantages of these artificial skins compared with skin grafts are the lack of resource limitations as well as the absence of inflammatory and immune reactions. [10][11][12][13] Considering two-dimensional nature of the skin, it seems that the design and construction of threedimensional porous scaffolds with nanometer structures have a very high potential in the treatment and reconstruction of skin injuries by using TE strategy. In skin tissue engineering (STE), a suitable scaffold should simulate the natural extracellural matrix (ECM) of skin, motivate wound healing process, increase permeability to oxygen and moisture, and inhibit infection.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, tissue engineering (TE) has been recommended as an efficient alternative to circumvent the abovementioned issues and fabricating artificial skin substitutes. The most important advantages of these artificial skins compared with skin grafts are the lack of resource limitations as well as the absence of inflammatory and immune reactions 10–13 . Considering two‐dimensional nature of the skin, it seems that the design and construction of three‐dimensional porous scaffolds with nanometer structures have a very high potential in the treatment and reconstruction of skin injuries by using TE strategy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanofibrous electroconductive scaffolds composed of poly(vinyl alcohol) and modified polyaniline for skin tissue engineering application

Javid,

Eskandani,

Jaymand

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Nanofibrous electroconductive scaffolds were designed and fabricated using electrospinning approach based on a poly(vinyl alcohol)‐grafted polyaniline (PVA‐g‐PANI) and neat PVA with various PVA‐g‐PANI content for skin tissue engineering (STE) application. At first, phenylamine‐functionalized PVA macromonomer was synthesized, and then aniline was grafted onto macromonomer by an oxidation polymerization technique. The resultant PVA‐g‐PANI with different ratios was co‐electrospun with PVA to afford PVA‐g‐PANI/PVA electrically conductive nanofibrous scaffolds. Physicochemical features of the scaffolds, including water uptake properties, surface wettabilities, and morphologies as well as biological properties such as biodegradabilities, cytocompatibilities, cells adhesion and proliferation potentials, hemolysis rates, and protein adsorption capacities were investigated. Surface wettabilities of the scaffolds were altered from 55.7° for pure PVA up to 105.1° for the scaffold with the highest PVA‐g‐PANI content (30 wt%). It was found that the biodegradation rates of the scaffolds were decreased by increasing PVA‐g‐PANI content owing to very low biodegradation nature of PANI. Hemolysis assay revealed that all scaffolds were nonhemolytic (hemolysis rate <2%), except the scaffold that fabricated with 30 wt% of PVA‐g‐PANI. As results, the constructed scaffolds with 15 and 20 wt% of PVA‐g‐PANI (S3 and S4, respectively) exhibited higher potentials in both physicochemical and biological properties for STE application.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%