Skin Wound Healing

Sun, Zhao Li; Williams, G. M.

doi:10.1016/b978-0-12-802225-2.00018-0

Cited by 6 publications

(3 citation statements)

References 124 publications

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“…CHS significantly induced the proliferation and migration of dermal fibroblasts, indicating how CHS potentially facilitates dermal restoration through migration and proliferation of fibroblasts to close the wound site and re-establish the skin's barrier function. Accordingly, the increase in proliferation and migration is in agreement with literature that the secretome influences the success of tissue healing during skin regeneration (23,29,30). Besides the increase of cell viability, CHS can potentially regulate ECM synthesis in HDFs.…”

Section: Cordycepin-induced Hacat Secretome (Chs) Regulated the Expre...supporting

confidence: 89%

Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration

Kunhorm

Chaicharoenaudomrung

Noisa

2023

In Vivo

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Section: Cordycepin-induced Hacat Secretome (Chs) Regulated the Expre...supporting

confidence: 89%

Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration

Kunhorm

Chaicharoenaudomrung

Noisa

2023

In Vivo

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“…Pretreatment of BMCs show better cell survival, help to suppress inflammatory factors and immune response, and improve functional recovery. 43 BM-derived cells play a vital role in tissue maintenance throughout the body. 44 The specification in the growth factors determines the specific regeneration of tissue in that area.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

Fatima

Saleem

2021

The International Journal of Lower Extremity Wounds

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The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

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“…Platelets stick to each other and form a platelet plug. In case of a torn tissue, information is sent to the clotting factors floating in the nearby blood and fibrin is produced that in turn tightly bounds the platelets leading to coagulation [37] [38]. In inflammatory stage, vascular inflammatory response increases the blood flow to the deficient area.…”

Section: Introductionmentioning

confidence: 99%

Design and simulation of microfluidic smart bandage using Comsol Multiphysics

Rajput¹

2021

TURCOMAT

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Microfluidics is an emerging field finding its applications in biomedical engineering for investigations of cellular micro structures. Human body is composed of 70% of water having thin and fine structure of microfluidic blood channels spread throughout the body. These microchannels supply essential nutrients to each part of the body at right time and in right amount. Microfluidics is the science of controlling and manipulating the fluid in micro channels. Manipulating the flow through the microchannels is useful for developing electronic devices, artificial human body parts, and economical diagnostics tools. Microfluidics also helps in manufacturing of pharmaceuticals and carrying out precise chemical analysis of complex systems. A number of diagnostic devices and artificial human organs like lungs, heart, kidneys, etc. have been simulated using microfluidics for developing easy, economical, non-invasive, and rapid method of drug testing. Recently, its applications have also been investigated in smart bandage design. Further, blend of microfluidics with herbal medicines is expected to enhance the healing along with negligible side effects unlike allopathic treatments. The scope of the present research is to develop a smart bandage capable of sensing the status of the wound and supplying required amount of drugs using microfluidic channels. The flow rate of drugs through microchannels is simulated using the physics of laminar flow, capillary action, and diffusion phenomena for optimizing the size and shape of the constituent components of the bandage like microfluidic channels, mixers, and porous material used for drug distribution with in the active area of the bandage. The analysis of the results shows that the mixer having inner radius as 150 microns and outer radius as 250 microns is sufficient to mix the incoming drugs via inlets of 50 microns’ diameter. Results also show that capillary action dominates the diffusion phenomenon for supplying the drugs to the wound. The investigations of the prototype show that a smart bandage having the provisions of uniform drug distribution, automatic control, on board pH, moisture, O2 measurement, and dc current based healing mechanism is possible to be incorporated with in a comfortable size for fast wound healing.

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Skin Wound Healing

Cited by 6 publications

References 124 publications

Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration

Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

Design and simulation of microfluidic smart bandage using Comsol Multiphysics

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