Skull Metastasis from Renal Cell Carcinoma Case Report and Literature Review

Koutnouyan, Hrair A.; Rumore, Gregory J.; Kahn, Jonathan M.

doi:10.1177/000348949810700710

Cited by 20 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Forbes et al [10] reviewed 1,668 patients with RCC and only five patients developed skull metastasis. Out of all the cases documented with skull metastasis, in only seven cases, along with the current case, calvarial metastasis was the first presentation [4][5][6][7][8][9]. Occipital and frontal bones have been found to be commonly involved.…”

Section: Discussionmentioning

confidence: 88%

“…In some cases, metastasis precedes the clinical manifestations of the primary tumor as noted in our case. However, calvarium is an extremely rare site for a metastatic RCC [4][5][6][7][8][9]. Forbes et al [10] reviewed 1,668 patients with RCC and only five patients developed skull metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Other commonly occurring tumors in the calvarial location (in occipital bone) such as chordoma, germinoma, paraganglioma, hemangioblastoma, clear cell meningioma, oligodendroglioma (in view of intracranial extension) as well as other metastatic tumors which exhibit clear cell morphology were considered as in previous studies [4,6,7]. Clear cell sarcoma of kidney also known as "bone metastatising tumor" found in younger age group can present with skull metastasis [7].…”

Section: Discussionmentioning

confidence: 99%

“…Calvarium is an extremely unusual site for a metastatic RCC. There are only a handful of reports in the literature describing calvarial mass as the primary presentation of a disseminated RCC [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Calvarial Metastasis of a Renal Cell Carcinoma, Mimicking a Primary Alveolar Soft Part Sarcoma, in a Young Girl—a Rare Case Report

Rekhi

Kumar

Menon

et al. 2008

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) is characterized by an unpredictable clinical behavior. It has a tendency for early metastasis, which, at times is the initial presentation and therein poses a diagnostic challenge. We present a rare case of a disseminated RCC in a 15-year-old girl, who primarily presented with an occipital soft tissue mass. Computed tomography (CT) of the head revealed a soft tissue mass in the scalp, eroding the occipital bone and extending intracranially. Biopsy examination showed overlapping features of an alveolar soft part sarcoma (ASPS) and a RCC. Immunohistochemistry (IHC) showed diffuse positivity for CD10 and focal positivity for vimentin. Cytokeratin (CK) and epithelial membrane antigen (EMA) were negative. The patient was recommended a clinical 'work-up' to rule out a possible primary in the kidneys. Her CT scan abdomen unraveled a large, lobulated, heterogeneous cystic mass, involving the middle and upper pole of the left kidney. Diagnosis of a metastatic RCC was ascertained. The present case represents a rare manifestation of a RCC metastasizing at an unusual location i.e. calvarium in the youngest patient known, so far and masquerading a primary ASPS. It also highlights the value of clinico-patho-radiological correlation, including CD10 as a useful IHC marker in diagnosing a RCC in young patients, especially when histopathological features overlap with ASPS.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Calvarial Metastasis of a Renal Cell Carcinoma, Mimicking a Primary Alveolar Soft Part Sarcoma, in a Young Girl—a Rare Case Report

Rekhi

Kumar

Menon

et al. 2008

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…Only a subpopulation of cells in the primary tumor has the properties of genetic, biochemical, immunological and biological for metastasis [5].…”

Section: Discussionmentioning

confidence: 99%

Metastasis to Paranasal Sinuses as the First Presenting Sign of Renal Cell Carcinoma

Bechara¹,

Júnior²,

Gouveia³

et al. 2012

OJU

View full text Add to dashboard Cite

The clear cell carcinoma is a relatively rare tumor, represented approximately 85% by renal cell carcinoma (RCC), but has a characteristic of early metastatic, which sometimes spread to unusual places. Metastatic tumors in the paranasal sinuses are very rare. This case report a 65 years-old patient who presented sinusitis and epitaxis as a first sign of renal cell carcinoma with metastasis to the right maxillary sinus, which was opereted at Lagoa Hospital-RJ and strengthen the inclusion of this disease in the differential diagnosis of sinus disease. The renal cell carcinoma is a relatively rare tumor, representing approximately 3% of malignant tumors. About a third of patients with renal cell carcinoma have metastasis at diagnosis. The sinuses are a rare location of metastasis. The maxillary sinuses and the paranasal sinuses are most commonly affected by metastatic tumors to the sinuses region. The most frequent primary tumor to metastasis to paranasal sinuses is the renal cell carcinoma. This report highlights the rarity of the case and the importance in the differential diagnosis of sinus disease.

show abstract

Metastasectomy for extracalvarial renal cell carcinoma

Abo Kasem,

Joseph,

Shaik

et al. 2024

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessagePalliative surgical resection of extra‐calvarial metastatic lesions from renal cell tumors is crucial for controlling metastatic spread, improving quality of life, and preventing associated morbidity. Careful surgical planning, including selective preoperative embolization and controlled resection around critical structures such as the sagittal sinus, is essential for successful outcomes. Cranioplasty with Titanium mesh and bone cement post‐resection can provide symptomatic relief, better cosmesis, and overall improved quality of life.AbstractRenal cell carcinomas are aggressive tumors with distant systemic disease. The calvarium appears to be an unusual and rare site for distant metastasis. The treatment modalities are challenging and out of the normal realm for the management of these tumors. We report a case of a 63‐year‐old woman with a previous history of nephrectomy who presented with symptoms of severe headaches, and swelling of bi‐frontal and bi‐parietal scalp regions due to multifocal extracalvarial disease. Preoperative bilateral superficial temporal artery embolization was performed to control the intraoperative bleeding. Surgical technique has been described with the critical steps involved, and a literature review has been conducted. Palliative tumor resection surgery was performed to improve the patient's quality of life as well as to confirm the histopathological diagnosis. Gross total resection of the extracalvarial metastatic tumor was achieved. Biopsy confirmed renal cell tumor with the clear cell subtype. The patient recovered well from her surgery with slow healing of the scalp wound. At 6‐month follow‐up, no recurrence of the extracalvarial disease was observed on serial imaging. Extracalvarial metastasis is a rare presentation in renal cell carcinoma. Considering the inherent radioresistant nature of the tumor, palliative surgical resection can be offered to control the metastatic spread, relieve agonizing pain symptoms, and to improve the quality of life. Preoperative embolization helps to decrease intraoperative blood loss. Moreover, palliative surgical resection of extracalvarial diseases helps to treat the metastasis as well as avoiding the associated morbidity that may occur if left untreated.

show abstract

Skull Metastasis from Renal Cell Carcinoma Case Report and Literature Review

Cited by 20 publications

References 10 publications

Calvarial Metastasis of a Renal Cell Carcinoma, Mimicking a Primary Alveolar Soft Part Sarcoma, in a Young Girl—a Rare Case Report

Calvarial Metastasis of a Renal Cell Carcinoma, Mimicking a Primary Alveolar Soft Part Sarcoma, in a Young Girl—a Rare Case Report

Metastasis to Paranasal Sinuses as the First Presenting Sign of Renal Cell Carcinoma

Metastasectomy for extracalvarial renal cell carcinoma

Contact Info

Product

Resources

About