Sleep Architecture and REM Sleep Measures in Prepubertal Children With Major Depression

Puig-Antich, Joaquim; Goetz, Raymond R.; Hanlon, Cleo; Davies, Mark; Thompson, J. Kevin; Chambers, William J.; Tabrizi, Mary Ann; Weitzman, Elliot D.

doi:10.1001/archpsyc.1982.04290080046007

Cited by 166 publications

(40 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…29 In depressed children and adolescents, no sleep EEG changes were found in comparison to age-matched healthy controls in most studies. [30][31][32] In contrast, other studies reported similar changes in depressed adults, children, and adolescents. 26,33,34 Kupfer and Foster submitted the hypothesis that a shortened REM latency is a specific marker of depression.…”

Section: Controlsmentioning

confidence: 83%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

View full text Add to dashboard Cite

Abstract:The sleep electroencephalogram (EEG) provides biomarkers of depression, which may help with diagnosis, prediction of therapy response, and prognosis in the treatment of depression. In patients with depression, characteristic sleep EEG changes include impaired sleep continuity, disinhibition of rapid-eye-movement (REM) sleep, and impaired non-REM sleep. Most antidepressants suppress REM sleep in depressed patients, healthy volunteers, and in animal models. REM suppression appears to be an important, but not an absolute requirement, for antidepressive effects of a substance. Enhanced REM density, a measure for frequency of REM, characterizes high-risk probands for affective disorders. REM-sleep changes were also found in animal models of depression. Sleep-EEG variables were shown to predict the response to treatment with antidepressants. Furthermore, certain clusters of sleep EEG variables predicted the course of the disorder for several years. Some of the predicted sleep EEG markers appear to be related to hypothalamic-pituitary-adrenal system activity.

show abstract

Section: Controlsmentioning

confidence: 83%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

View full text Add to dashboard Cite

show abstract

“…27 Considering all studies in this field, the only relatively consistent finding emerging from the cumulative subjective and objective sleep studies is related to increased sleep latency. 24 Reduced REM sleep latency may also be found in depressed youth.…”

Section: Sleep and Depressionmentioning

confidence: 99%

Sleep, emotional and behavioral difficulties in children and adolescents

Gregory

Sadeh

2012

Sleep Medicine Reviews

590

389

View full text Add to dashboard Cite

“…This group has described a markeu dissociation between sleep complaints and polysomnographic abnormalities in prepubertal depressives during an episode, compared with psychiatric and normal controls (18). We hypothesized that the presence or absence of clinical sleep complaints might be related to sleep spindle characteristics.…”

mentioning

confidence: 96%

Spindle Characteristics in Prepubertal Major Depressives During an Episode and After Sustained Recovery: A Controlled Study

Goetz

Hanlon

et al. 1983

Sleep

Self Cite

View full text Add to dashboard Cite

Summary: In a previous publication, this group reported a dissociation between multiple sleep complaints and polysomnographic abnormalities in prepubertal major depressive children. Spindle activity has been thought by some to be a correlate of restorative sleep. On this basis, it was hypothesized that prepubertal depressives might exhibit differences in sleep spindle characteristics when compared with normal and psychiatric control groups, and with their former state during sustained recovery in a drug-free state. Further, it was thought that clinical complaints of disrupted sleep might be related to differences in spindle characteristics. Spindle frequency (Hz) was the only significant finding among the groups, but it was not specific to depressive disorder, since all psychiatric groups presented higher frequencies than did normal children. As expected, significant differences across halves of the sleep period time (SPT) were also found for the number of spindles, frequency (Hz), duration (ms), spindle density (rate), and the amount of stage 2 sleep (min). The presence or absence of sleep complaints had no bearing on spindle characteristics, thus indicating a lack of apparent relationship between the two. Upon recovery the depressives exhibited no changes across clinical state, and a cross-sectional comparison of the recovered data with the original control data gave results essentially identical to the first (active illness) comparisons. It is suggested that high spindle frequency may be a nonspecific correlate of emotional disorders in prepuberty, which, at least in depressives, does not change with clinical state. Key Words: Spindle characteristics-Prepubertal depressives-Across clinical states.Various polysomnographic patterns have been shown to be associated with neuropsychiatric illnesses in humans, for instance, shortened first REM period latency, increased REM density, and other sleep continuity/architecture changes among adult depressives 0), and REM sleep abnormalities among schizophrenics (2). Research investigating specific EEG waveform parameters has also shown that certain wave

show abstract

Sleep Architecture and REM Sleep Measures in Prepubertal Children With Major Depression

Cited by 166 publications

References 23 publications

Sleep electroencephalography as a biomarker in depression

Sleep electroencephalography as a biomarker in depression

Sleep, emotional and behavioral difficulties in children and adolescents

Spindle Characteristics in Prepubertal Major Depressives During an Episode and After Sustained Recovery: A Controlled Study

Contact Info

Product

Resources

About