Sleep Disorder, Gastrointestinal Problems  and Behaviour Problems Seen in Autism  Spectrum Disorder Children and Yoga as  Therapy: A Descriptive Review

Narasingharao, Kumar; Pradhan, Balaram; Navaneetham, Janardhana

doi:10.7860/jcdr/2016/24175.8922

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…Autism spectrum disorder (ASD) is considered as a relatively serious developmental disorder in brain [1], usually congenital and found in early childhood development [2, 3]. It is currently one of the most severe childhood psychiatric diseases, which mainly manifested in social and communication dysfunction [4], language dysfunction [5], and repetitive ritualized stereotypes [6].…”

Section: Introductionmentioning

confidence: 99%

Tracking the Brain State Transition Process of Dynamic Function Connectivity Based on Resting State fMRI

Liu

Xue²,

Cheng³

et al. 2019

Computational Intelligence and Neuroscience

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BOLD-fMRI technology provides a good foundation for the research of human brain dynamic functional connectivity and brain state analysis. However, due to the complexity of brain function connectivity and the high dimensionality expression of brain dynamic attributions, more research studies are focusing on tracking the time-varying characteristics through the transition between different brain states. The transition process is considered to occur instantaneously at some special time point in the above research studies, whereas our work found the brain state transition may be completed in a time section gradually rather than instantaneously. In this paper, a brain state conversion rate model is constructed to observe the procedure of brain state transition trend at each time point, and the state change can be observed by the values of conversion rate. According to the results, the transition of status always lasts for a few time points, and a brain state network model with both steady state and transition state is presented. Network topological overlap coefficient is built to analyze the features of time-varying networks. With this method, some common regular patterns of time-varying characteristics can be observed strongly in healthy children but not in the autism children. This distinct can help us to distinguish children with autism from healthy children.

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Section: Introductionmentioning

confidence: 99%

Tracking the Brain State Transition Process of Dynamic Function Connectivity Based on Resting State fMRI

Liu

Xue²,

Cheng³

et al. 2019

Computational Intelligence and Neuroscience

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“…These symptoms not only aggravate the symptoms of autism itself but also lead to other behavioral problems [34]. ASDs can be categorized as the "Yu" differentiation grouping of TCM.…”

Section: Discussionmentioning

confidence: 99%

“…Among these characteristics, loss of appetite and GI problems are common with this constitution, which shows features that are similar to the typical symptoms of autism. These symptoms not only aggravate the symptoms of autism itself but also lead to other behavioral problems [ 34 ]. ASDs can be categorized as the “ Yu ” differentiation grouping of TCM.…”

Section: Discussionmentioning

confidence: 99%

Treatment with the traditional Chinese medicine <i>BuYang HuanWu Tang</i> induces alterations that normalize the microbiome in ASD patients

Zhang

Cai

et al. 2020

Bioscience of Microbiota, Food and Health

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Autism spectrum disorders (ASDs) are prevalent neurobiological conditions with complicated causes worldwide. Increasing researcher awareness of ASD and accumulated evidence suggest that the development of ASD may be strongly linked to the dysbiosis of the gut microbiota. In addition, most of the current studies have compared autistic children and neurotypical children or have compared ASD patients before and after antibiotic treatment. Treatment of autism with traditional Chinese medicine (TCM) has increasingly been promoted, but the relationship between its efficacy and intestinal flora has rarely been reported. Under the premise that treatment with the TCM BuYang HuanWu Tang is effective, we conducted a comparative bioinformatics analysis to identify the overall changes in gut microbiota in relation to ASD by comparing the intestinal flora before and after treatment with TCM and contrasting the intestinal flora with that of healthy controls. At the phylum level, Proteobacteria showed a significant increase in children with ASD, which may be a signature of dysbiosis in the gut microbiota. At the genus level, Blautia, Coprococcus 1, the Lachnospiraceae family, and the Ruminococcaceae family were found at the lowest levels of relative abundance in children with ASD, whereas the abundances of Escherichia-Shigella, Klebsiella, and Flavonifractor were significantly increased compared with those in the healthy control group. In sum, this study characterized the alterations of the intestinal microbiome in children with ASD and its normalization after TCM treatment (TCMT), which may provide novel insights into the diagnosis and therapy of ASD.

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“…Patients with ASD associated with intellectual disability often have a pre-existing sleep disorder. [ 1 – 4 , 18 – 20 ] It has been suggested that insomnia symptoms of sleep problems, such as increased sleep onset latency, increased wake after sleep onset episodes, and reduced total sleep time, are commonly experienced with ASD. [ 14 , 15 ] Therefore, we consider that daily medication with these drugs for maintenance of mental condition might have a major influence on sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Study on the preventive effect of ramelteon on the onset of sleep disorder after general anesthesia in patients with autism spectrum disorder

Ayuse¹,

Ozaki-Honda

Kurata

et al. 2020

Medicine

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Background: The persistent loss of consciousness caused by general anesthesia without the existence of repeated 90-minute cycles of non-REM and REM sleep might significantly disturb and suppress the cycle of normal physiological sleep in postoperative periods after general anesthesia. Patients with autism spectrum disorders (ASD) with existing circadian rhythm disorder are reported to rapidly deteriorate due to acute sleep disorder during the perioperative period after general anesthesia. A melatonin receptor agonist, ramelteon (Rozerem), which is a sleep cycle regulator, is used as a therapeutic drug for patients with sleep disorders, but there are no studies on the prevention of postoperative sleep disorder after general anesthesia. In this study, we investigate whether prophylactic administration of a sleep-inducing substance, a melatonin receptor agonist, is effective against sleep disorder after general anesthesia in patients with ASD. Methods/design: This study is intended for patients with ASD aged 12 years and above who undergo treatment at Nagasaki University Hospital, Isahaya General Hospital Dentistry, and Sasebo City General Medical Center Dentistry and undergo dental treatment under general anesthesia. A melatonin receptor agonist (Rozerem) will be taken 7 days prior and 7 days postsurgery in patients diagnosed with insomnia. A randomized comparison will be made between 2 groups: an experimental group that is additionally administered Rozerem and a control group. The primary endpoint is the incidence of NREM-REM sleep disorders that occur within 3 to 5 days after general anesthesia. The secondary endpoint is the incidence of circadian rhythm sleep disorders (rate of occurrence of sleep-retardation syndrome with drowsiness and strong fatigue). Discussion: Postoperative sleep disorders after general anesthesia has been reported in patients with ASD; however, effective preventive pharmacological treatments have not been established. A sleep cycle regulator, ramelteon (Rozerem), is used as a therapeutic drug for patients with sleep disorders by decreasing the difficulty of falling asleep in insomnia. If sleep disorder can be prevented after the administration of general anesthesia in patients with ASD, we can support social participation while maintaining their quality of life. Trial registration: The study was registered with the jRCT1071200030.

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Sleep Disorder, Gastrointestinal Problems and Behaviour Problems Seen in Autism Spectrum Disorder Children and Yoga as Therapy: A Descriptive Review

Cited by 10 publications

References 22 publications

Tracking the Brain State Transition Process of Dynamic Function Connectivity Based on Resting State fMRI

Tracking the Brain State Transition Process of Dynamic Function Connectivity Based on Resting State fMRI

Treatment with the traditional Chinese medicine <i>BuYang HuanWu Tang</i> induces alterations that normalize the microbiome in ASD patients

Study on the preventive effect of ramelteon on the onset of sleep disorder after general anesthesia in patients with autism spectrum disorder

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