Sleep disordered breathing in cystic fibrosis

Milross, Maree; Piper, Amanda J.; Dobbin, Catherine J.; Bye, Peter; Grunstein, Ronald R.

doi:10.1016/j.smrv.2004.03.004

Cited by 48 publications

(49 citation statements)

References 67 publications

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“…İAH tanılı olgular, kronik hastalığa bağlı stres, solunum anormallikleri ve tedavi yan etkileri gibi nedenlerle uyku bozuklukları açısından risk altındadırlar (4,16). Özellikle İPF gibi halen etkin tedavisi olamayan İAH hastalarında, hastalık progresyonunun yavaşlatılmasında uyku bozuklukları gibi eşlik eden komorbiditelerin önlenmesi ve tedavi edilmesi önemlidir (6).…”

Section: Sonuçunclassified

Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Hanci¹,

Alpaydın²,

İtil³

et al. 2016

jtsm

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Objective:Interstitial lung disease (ILD) may create sleep disturbances due to chronic disease-related stress, respiratory abnormalities and adverse effects of treatment. We aimed to determine the quality of sleep in ILD patients, and the incidence of Obstructive sleep apnea syndrome (OSAS) in these patients. Materials and Methods: Taken to this study were 52 patients who were followed up in our center due to ILD. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were applied to the patients. Spirometry and diffusion test were performed. Polysomnography (PSG) was performed to 27 patients whose ESS were more than or equal to 10. Results: Demographic characteristics, body mass index, spirometry and diffusion measurements, PSQI global score and the sub-components of it didn't show difference according to ESS daytime sleepiness.

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Section: Sonuçunclassified

Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Hanci¹,

Alpaydın²,

İtil³

et al. 2016

jtsm

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“…O comprometimento da função pulmonar é responsável pela maioria das mortes dos pacientes com FC, seguido de insuficiência respiratória, hipertensão pulmonar e cor pulmonale 3,4 .…”

Section: Introductionunclassified

“…Vários fatores podem levar a perturbações e fragmentações do sono nesses pacientes, incluindo hipóxia noturna, hipoventilação, tosse crônica, inflamação crônica e efeitos de drogas 3 . Os distúrbios respiratórios do sono (DRS), especialmente a síndrome da apneia obstrutiva do sono (SAOS), podem também levar a perturbações no sono, causando, posteriormente, alterações na ventilação e na troca gasosa em pacientes com FC, o que pode ser agravado pela presença de doença pulmonar avançada.…”

Section: Introductionunclassified

“…Os distúrbios respiratórios do sono (DRS), especialmente a síndrome da apneia obstrutiva do sono (SAOS), podem também levar a perturbações no sono, causando, posteriormente, alterações na ventilação e na troca gasosa em pacientes com FC, o que pode ser agravado pela presença de doença pulmonar avançada. Essas alterações podem resultar em dessaturação da oxi-hemoglobina e hipercapnia, particularmente durante o estágio REM (rapid eye movement) do sono 3 .…”

Section: Introductionunclassified

“…Dados prévios têm demonstrado que a obstrução das vias aéreas superiores causada por infecção crônica e polipose nasal pode contribuir para a presença e a severidade da SAOS em pacientes com FC 3,5,6 . No entanto, a SAOS não é considerada uma causa importante de distúrbios do sono em pacientes com FC, nem parte integrante da etiologia da dessaturação da oxi-hemoglobina observada nesses pacientes 3 .…”

Section: Introductionunclassified

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Arquitetura do sono e perfil respiratório polissonográfico de crianças e adolescentes com fibrose cística

Ramos¹,

Salles²,

Daltro³

et al. 2011

J Pediatr (Rio J)

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Objectives: To evaluate sleep architecture in children and adolescents with both cystic fibrosis (CF) and a clinical suspicion of sleep-disordered breathing (SDB), and to identify the respiratory polysomnographic profile of these patients.Methods: Parents or guardians of children with CF filled out a questionnaire designed to assess their clinical and sleep conditions. Children who were identified as having behaviors associated with SDB underwent polysomnography. After polysomnography, patients were grouped according to the obstructive apnea index (AI) obtained (either < 1 or ≥ 1), and a multiple correspondence factor analysis was used to analyze and identify the polysomnographic profile of patients. Results:Of the 74 patients who met inclusion criteria for this study, 67 underwent polysomnography, and 38 (56.7%) of the 67 patients showed an AI ≥ 1. Median age was 8 years. The group of patients with an AI ≥ 1 was characterized by total sleep time (TST) during stage 4 and rapid eye movement (REM) stage of sleep < 21 and 13%, respectively, REM sleep latency > 144 minutes, percentage of TST with pulse oxyhemoglobin saturation (SpO 2 ) < 90% higher than 0.28 seconds, and an oxygen desaturation index higher than 0.92. Conclusion:Results suggest that clinically stable pediatric patients with CF have a high prevalence of SDB and present frequent sleep complaints, significant changes in sleep architecture, and episodes of oxygen desaturation during sleep.J Pediatr (Rio J). 2011;87(1):63-69:: Cystic fibrosis, children, adolescents, polysomnography, obstructive sleep apnea. ResumoObjetivos: Avaliar a arquitetura do sono em crianças e adolescentes com fibrose cística (FC) e com suspeita clínica de distúrbios respiratórios do sono (DRS), e identificar o perfil respiratório polissonográfico desses pacientes. Métodos:Os pais ou responsáveis dos pacientes com FC preencheram um questionário que abordava questões clínicas e relacionadas ao sono.As crianças e adolescentes que foram identificadas com quadro clínico sugestivo de DRS foram submetidas a polissonografia. Após a realização da polissonografia, os pacientes foram agrupados de acordo com o índice de apneia obstrutiva (IA) observado (< 1 ou ≥ 1) e utilizou-se a análise fatorial de correspondência múltipla para análise e identificação dos perfis polissonográficos dos pacientes.Resultados: Dos 74 pacientes que preencheram os critérios de inclusão para este estudo, 67 foram submetidos à polissonografia; observou-se que 38 (56,7%) dos 67 pacientes apresentaram um IA ≥ 1. A mediana das idades foi de 8 anos. O grupo de pacientes com IA ≥ 1 caracterizou-se por apresentar tempo total de sono (TTS) nos estágios 4 e no REM < 21 e 13%, respectivamente, latência do sono REM > 144 minutos, o percentual de TTS com saturação da oxi-hemoglobina medida por oximetria de pulso (SpO 2 ) < 90% maior que 0,28 segundos e o índice de dessaturação de oxigênio maior que 0,92. Conclusão:Os resultados sugerem que pacientes pediátricos clinicamente estáveis com FC têm uma alta prevalência de D...

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Early Occurrence of Obstructive Sleep Apnea in Infants and Children With Cystic Fibrosis

Spicuzza¹,

Sciuto²,

Leonardi³

et al. 2012

Arch Pediatr Adolesc Med

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To assess the occurrence of sleepdisordered breathing, hypoxemia, and sleep architecture in a cohort of infants and children with cystic fibrosis (CF) and normal or mildly impaired lung function in stable clinical condition. Design: Case-control study. Setting: Cystic Fibrosis Unit of a university hospital and pediatric sleep laboratory. Participants: A total of 40 children (aged 6 months to 11 years) with CF in stable condition and 18 healthy agematched control subjects. Intervention: Nocturnal sleep and cardiorespiratory monitoring was performed using a full polysomnographic recording in a sleep laboratory. Main Outcomes Measures: Sleep architecture and respiratory variables. Results: Although awake oxyhemoglobin saturation (SaO 2) values were similar in the 2 groups (98%), the CF group had significantly lower values of nocturnal mean SaO 2. The apnea-hypopnea index was significantly higher in the CF group compared with the controls (mean [SE], 7.3 [1.3] vs 0.5 [0.4], respectively, P Ͻ .001), particularly in preschool-aged children and in children with upper airway abnormalities. In addition, 28 (70%) of the 40 children with CF had mild to moderate obstructive sleep apnea (defined as an apnea-hypopnea index Ͼ2). Children with CF compared with controls also had reduced sleep efficiency (CF group vs controls mean [SE], 80% [41%] vs 88% [13.1%], P Ͻ.001), rapid eye movement sleep duration (11% [0.9%] vs 13% [1%], PϽ.05), and increased number of arousals per hour (11.0 [10] vs 8.2 [0.7], P Ͻ.001). Conclusions: This study showed an early occurrence of obstructive sleep apnea in children with CF in stable condition, associated with a mild level of sleep disruption. Early routine nocturnal respiratory monitoring is advised in children with CF.

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Sleep disordered breathing in cystic fibrosis

Cited by 48 publications

References 67 publications

Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Evaluation of Sleep Related Breathing Disorders and Obstructive Sleep Apne Syndrome in Interstitial Lung Patients

Arquitetura do sono e perfil respiratório polissonográfico de crianças e adolescentes com fibrose cística

Early Occurrence of Obstructive Sleep Apnea in Infants and Children With Cystic Fibrosis

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