Sleep-disordered breathing in patients with COPD and mild hypoxemia: prevalence and predictive variables

Júnior, José Laerte Rodrigues Silva; Conde, Marcus Barreto; Corrêa, Krislainy de Sousa; Rabahi, Helena; Rocha, Arthur Alves; Rabahi, Marcelo Fouad

doi:10.1590/s1806-37562016000000051

Cited by 10 publications

(7 citation statements)

References 31 publications

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“…The normal range for PaO 2 was defined as PaO 2 >80 mmHg; mild hypoxia was defined as 60 mmHg<PaO 2 ≤ 80 mmHg [18]. The normal range for SaO 2 was defined as SaO 2 >94%; mild hypoxia was defined as 90% ≤ SaO 2 ≤ 94% [19].…”

Section: Methodsmentioning

confidence: 99%

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Yin

Wang

et al. 2019

BMC Pulm Med

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BackgroundTo explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI).MethodsA total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed.ResultsThere was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1.ConclusionsThese findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.

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Section: Methodsmentioning

confidence: 99%

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Yin

Wang

et al. 2019

BMC Pulm Med

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“…Two studies, one using an AHI cut-off ≥ 5events/hr with symptoms [13] and one > 10events/hr [15] found a significantly increased risk of hypertension in the overlap population compared to the COPD population [OR=2.42, 95%CI 1.58-3.69) and OR 2.56, 95%CI 1.18-5.57 respectively]. While a remaining five studies [18,20,21,31,32] found no significant difference. Only one study investigated cardiovascular mortality [15] and found a significantly increased risk in patients with overlap compared to COPD patients (OR=2.81, 95%CI 1.40-5.64).…”

Section: Comparison Of Cardiovascular Outcomes Between Patients With ...mentioning

confidence: 99%

“…A total of 17 studies [11][12][13][14][15][16][17][18][19][20][21][22]29,[31][32][33][34] (n= 4580) looked at the prevalence of hypertension in the overlap population (Figure S2). Studies were heterogenous in terms of their AHI cut-off, with eight studies [11,12,16,17,22,29,33,34] using AHI ≥ 5events/hr (n=2000, pooled prevalence 57%, 95%CI 44%-71%); two [13,14] using AHI ≥ 5events/hr with symptoms (n=210, pooled prevalence 74%, 95%CI 68%-79%); two [15,21] using AHI > 10events/hr (n= 89, pooled prevalence 50%, 95%CI, 39%-60%); four [18][19][20]31] using AHI ≥ 15events/hr (n= 2267, pooled prevalence 60%, 95%CI 49%-71%) and one [32] using AHI ≥ 30events/hr (n= 14, pooled prevalence 64%, 95%CI 51%-66%).…”

Section: Hypertensionmentioning

confidence: 99%

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Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis

Quek

Alqahtani³

et al. 2022

Sleep Medicine Reviews

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“…Compared with healthy control subjects, poor sleep quality is more frequent in COPD patients. The prevalence of sleep-disordered breathing is reported to be between 50% and 60% in patients with COPD [7,8]. The most common symptoms include sleep onset insomnia, nighttime awakenings, and sleep deprivation [9,10].…”

Section: Introductionmentioning

confidence: 99%

The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease

et al. 2023

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Purpose Study the impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease (COPD) patients. Methods This was a prospective study. Patients with COPD were recruited into the study and followed up for one year. Pittsburgh sleep quality index (PSQI) was collected at baseline. Symptom change was assessed with Minimum clinically important difference (MCID) in COPD Assessment Test (CAT) at 6-month visit, which is an indicator to assess symptom improvement. Exacerbation was recorded during the one-year visit. PSQI score > 5 was defined as poor sleep quality, whereas PSQI score ≤ 5 was defined as good sleep quality. MCID was defined as attaining a CAT decrease ≥ 2. Results A total of 461 patients were enrolled for final analysis. Two hundred twenty-eight (49.4%) patients had poor sleep quality. Overall, 224 (48.6%) patients attained MCID at 6-month visit and the incidence of exacerbation during the one-year visit was 39.3%. Fewer patients with impaired sleep quality achieved MCID than patients with good sleep quality. Good sleepers were significantly more likely to attain MCID (OR: 3.112, p < 0.001) than poor sleepers. Fewer poor sleepers in GOLD A and D groups attained MCID with ICS/LABA, and fewer poor sleepers in the GOLD D group attained MCID with ICS/LABA/LAMA than good sleepers. Poor sleep quality was a greater risk factor of future exacerbation in Cox regression analysis. The ROC curves showed that PSQI score had a predictive capacity for future exacerbation. More patients with poor sleep quality experienced future exacerbation in GOLD B and D group with treatment of ICS/LABA/LAMA compared to good sleepers. Conclusions COPD patients with impaired sleep quality were less likely to achieve symptom improvement and were at increased risk of future exacerbation compared to patients with good sleep quality. Besides, sleep disturbance may affect the symptom improvement and future exacerbation of patients with different inhaled medication or in different GOLD groups.

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Sleep-disordered breathing in patients with COPD and mild hypoxemia: prevalence and predictive variables

Cited by 10 publications

References 31 publications

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Cardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis

The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease

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