Sleep factors were associated with a higher risk of MAFLD and significant fibrosis

Li, Yaxin; Tan, Shiyun

doi:10.1007/s11325-024-03017-0

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Patients with sleep-disordered SD have higher risk of NAFLD in a Taiwanese population-based study ( 96 ). In addition, poor sleep patterns were associated with a high risk of MAFLD and severe fibrosis, and sleep difficulties, snoring, excessive daytime sleepiness, and sleep apnea symptoms were positively associated with the odds of MAFLD when specific factors of sleep patterns were examined in isolation ( 97 ). Good sleep habits, therefore, help reduce the prevalence of MAFLD.…”

Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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MAFLD has become a major global health problem and is the leading cause of liver disease worldwide. The disease progresses from a simple fatty liver to gradual fibrosis, which progresses to cirrhosis and even hepatocellular liver cancer. However, the methods currently used for diagnosis are invasive and do not facilitate clinical assessment of the condition. As a result, research on markers for the diagnosis of MAFLD is increasing. In addition, there are no clinical medications for the treatment of MAFLD, and lifestyle interventions remain effective in the prevention and treatment of MAFLD. In this review, we attempt to make a summary of the emerging diagnostic indicators and effective lifestyle interventions for MAFLD and to provide new insights into the diagnosis and treatment of MAFLD.

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Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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Interaction between trouble sleeping and diabetes on metabolic dysfunction-associated fatty liver disease and liver fibrosis in adults results from the National Health and Nutrition Examination Survey 2017–2018

Zhang,

Cao,

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Background Metabolic dysfunction-associated fatty liver disease (MAFLD), trouble sleeping, and diabetes, as major public health problems, were closely related. The study examined the interaction between trouble sleeping and diabetes on MAFLD and liver fibrosis in adults with MAFLD. Methods The data were obtained from the National Health and Nutrition Examination Survey 2017–2018. Multivariate logistic regression model and subgroup analyses were conducted to assess the relationship between either trouble sleeping or diabetes on MAFLD and liver fibrosis. Relative excess risk due to interaction (RERI), attributable proportion of interaction (AP), and synergy index (S) were utilized to assess the additive interaction. Results Ultimately, 3747 participants were included, with 2229 known MAFLD subjects. Compared with participants without diabetes, those with diabetes had a higher risk of MAFLD [odds ratio (OR) = 5.55; 95% confidence interval (CI) = 4.07–7.56] and liver fibrosis risk (OR = 3.61; 95% CI = 2.67–4.89). We also found a significant association of trouble sleeping with an increased risk of MAFLD (OR = 1.54; 95% CI = 1.17–2.02) and liver fibrosis risk (OR = 1.51; 95% CI = 1.06–2.16), compared with those without trouble sleeping. Moreover, there was a significant interaction between diabetes and trouble sleeping on MAFLD [RERI = 1.76 (95% CI: −0.22 to 3.73), AP = 0.35 (95% CI: 0.08–0.63), S = 1.80 (95% CI: 1.02–3.16)] and liver fibrosis risk [RERI = 1.79 (95% CI: 0.37–3.21), AP = 0.44 (95% CI: 0.20–0.69), S = 2.44 (95% CI: 1.18–5.08)]. Conclusion The findings highlight that trouble sleeping and diabetes had a synergistic effect on MAFLD and liver cirrhosis. The study highlights the importance of addressing both trouble sleeping and diabetes management in adults to mitigate the risk of MAFLD and liver fibrosis.

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Impact of Sleep Fragmentation and Arousal on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study

Zhong,

Wang,

Huang

et al. 2024

NSS

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Purpose Obstructive sleep apnea (OSA) is a contributing factor to nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the clinical and polysomnographic characteristics of OSA patients with and without NAFLD, focusing on the relationships between sleep fragmentation, arousal and NAFLD. Materials and Methods We consecutively enrolled patients who underwent polysomnography, anthropometry, blood sampling, and abdominal ultrasonography. Patients were categorized into NAFLD and non-NAFLD groups. A comparative analysis of clinical and polysomnographic profiles was conducted, followed by multivariate binary logistic regression to explore the relationship between sleep disturbance indices and NAFLD. Results A total of 403 subjects were included, including 92 patients with NAFLD and 311 with non-NAFLD. NAFLD patients exhibited a greater apnea-hypopnea index (AHI) (51.19/h vs 33.60/h, p = 0.002) and oxygen desaturation index (ODI) (37.90/h vs 21.40/h, p=0.034) compared to non-NAFLD patients. Specifically, NAFLD patients had a higher rapid eye movement (REM)-AHI (53.70/h vs 43.60/h, p=0.001) and greater arousal index (AI) (32 vs 25, p = 0.009). Additionally, sleep latency (SL) was significantly lower in the NAFLD group (p < 0.05). Multivariate logistic regression analysis confirmed that REM-AHI (OR=1.023, p = 0.024), AI (OR=1.140, p = 0.01), and SL (OR=0.956, p = 0.035) were significantly associated with NAFLD in OSA patients. Conclusion This study revealed that sleep disturbance indices, especially AI, REM-AHI and SL, were closely related to NAFLD. When evaluating whether OSA patients are complicated with NAFLD, more attention should be given to sleep fragmentation and arousal.

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Sleep factors were associated with a higher risk of MAFLD and significant fibrosis

Cited by 3 publications

References 38 publications

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Interaction between trouble sleeping and diabetes on metabolic dysfunction-associated fatty liver disease and liver fibrosis in adults results from the National Health and Nutrition Examination Survey 2017–2018

Impact of Sleep Fragmentation and Arousal on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study

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