Sleep habits, academic performance, and the adolescent brain structure

Urrila, Anna S.; Artiges, Éric; Massicotte, Jessica; Miranda, Rubén; Vulser, Hélène; Bézivin-Frere, Pauline; Lapidaire, Winok; Lemaître, Hervé; Penttilä, Jani; Conrod, Patricia J.; Garavan, Hugh; Martinot, Marie‐Laure Paillère; Martinot, Jean‐Luc

doi:10.1038/srep41678

Cited by 96 publications

(92 citation statements)

References 37 publications

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“…Shorter sleep time in schoolchildren is associated with poorer cognitive and academic performance . Urrila et al also demonstrated correlations between shorter weekday sleep and later weekend sleeping hours in adolescents with decreased grey matter volumes in frontal, anterior cingulate, and precuneus cortex, suggesting that unsuitable sleeping schedules may have lasting effects on brain structure.…”

Section: Sleep: Evolution Over Childhood and Correlation With Neurodementioning

confidence: 99%

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Chan¹

2019

Develop Med Child Neuro

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Although the influence of sleep on epilepsy has long been recognized, this relationship has yet to be fully exploited to benefit patients. The past decade has seen significant advances in understanding paediatric sleep, providing a framework by which to properly evaluate the sleep of children with epilepsy, which itself has been subject to increasing scrutiny. The role of sleep in learning and the potential for interictal discharges to disrupt sleep‐related memory consolidation provide a novel perspective for understanding the association of childhood epilepsy with a high rate of intellectual disability. In this review, I outline the evolution of sleep duration, architecture, and homeostasis across childhood, relating this to the development of cognitive functions. I describe how these may be disrupted or preserved in children with epilepsy; in particular, collating data from polysomnography. Finally, I explore how sleep may, in the future, be modulated to improve cognitive outcome in these patients. What this paper adds Children with epilepsy have less rapid eye movement sleep than controls, but this improves with seizure cessation. Deep or slow‐wave sleep is highly conserved in children with epilepsy. Sleep homeostasis may be disrupted either at a local or global level by the presence of interictal epileptiform discharges.

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Section: Sleep: Evolution Over Childhood and Correlation With Neurodementioning

confidence: 99%

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Chan¹

2019

Develop Med Child Neuro

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“…Only the French adolescents were assessed for their sleep habits and were thus eligible for this study. Details of the sample at baseline have been previously reported (Urrila et al, 2017). This study focuses on the sample at age 16, at which time point written informed assent and consent to study participation were obtained from a total of 138 adolescents and their parents, respectively.…”

Section: Participantsmentioning

confidence: 99%

“…The hippocampus and amygdala masks were created with the Anatomical Automatic Labeling (AAL) atlas in SPM. The medial prefrontal region was marked with a 10 mm radius from coordinates [-2, 34, -14] taken from our previous results on an analogous sample at age 14, which indicated a strong relationship between sleep habits and GMV in this region (Urrila et al, 2017). Subsequently, it was investigated whether psychometrics measures (spatial working memory, delay discounting, internalising and externalising problems) were associated with grey matter volumes in these regions of interest.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…In our previous study of 14-year-old adolescents, we found late sleep during the weekend and short sleep during the week to be associated with smaller regional grey matter volumes, particularly in the medial prefrontal cortex (mPFC). In addition, there was a correlation between mPFC GMV and school performance (Urrila et al, 2017). Since sleep characteristics and brain morphology undergo constant changes though adolescence (Hagenauer et al, 2009;Gied et al, 2009), it is important to study their interconnections repeatedly at different points of development.…”

Section: Introductionmentioning

confidence: 99%

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Sleep, regional grey matter volumes, and psychological functioning in adolescents

Lapidaire

Urrila

Artiges

et al. 2019

Preprint

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Changing sleep rhythms in adolescents often lead to sleep deficits and increased variability in sleep schedules. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n=101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationship between regional grey matter volumes with psychological functioning. Sleep was assessed with self-reports and psychological functioning with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and both externalising and internalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development.

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“…In depressed adolescents, both structural and functional changes in the PFC have been reported, i.e., a trend towards decreased regional volumes, abnormal cortical thinning, and reduced activation in cognitive control and decision-making tasks [13]. The structure and function of the PFC have likewise been observed to correlate with sleep habits [14,15,16], sleep loss [17,18], and sleep pathologies [19,20,21]. …”

Section: Introductionmentioning

confidence: 99%

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study

Urrila¹,

Hakkarainen

Castaneda

et al. 2017

Neuropsychobiology

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Aim: This study used proton magnetic resonance spectroscopy (¹H MRS) to evaluate the neurochemistry of the frontal cortex in adolescents with symptoms of sleep and depression. Methods: Nineteen non-medicated adolescent boys (mean age 16.0 years; 9 clinical cases with depression/sleep symptoms and 10 healthy controls) underwent ¹H MRS at 3 T. MR spectra were acquired from the anterior cingulate cortex (ACC), the dorsolateral prefrontal cortex, and frontal white matter. Concentrations of N-acetyl aspartate, total creatine, choline-containing compounds, total glutamine plus glutamate, and myo-inositol (mI) were compared in the 2 subgroups, and correlated with sleep and clinical measures in the total sample. Sleep was assessed with self-report questionnaires and ambulatory polysomnography recordings. Results: Concentrations of mI were lower in both frontal cortical regions among the depressed adolescents than in controls. No statistically significant differences in other metabolite concentrations were observed between the subgroups. Frontal cortex mI concentrations correlated negatively with depression severity, subjective daytime sleepiness, insomnia symptoms, and the level of anxiety, and correlated positively with total sleep time and overall psychosocial functioning. The correlations between mI in the ACC and total sleep time as well as daytime sleepiness remained statistically significant when depression severity was controlled in the analyses. Conclusion: Lower frontal cortex mI may indicate a disturbed second messenger system. Frontal cortical mI may thus be linked to the pathophysiology of depression and concomitant sleep symptoms among maturing adolescents. Short sleep and daytime sleepiness may be associated with frontal cortex mI independently from depression.

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Sleep habits, academic performance, and the adolescent brain structure

Cited by 96 publications

References 37 publications

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Sleep, regional grey matter volumes, and psychological functioning in adolescents

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study

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