Sleep quality and its relationship with quality of life among high-risk pregnant women (gestational diabetes and hypertension)

Saadati, Fatemeh; Shafaei, Fahimeh Sehhatiei; Mirghafourvand, Mojgan

doi:10.1080/14767058.2016.1277704

Cited by 30 publications

(27 citation statements)

References 15 publications

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“…It was observed that as the life quality, "physical role limitation", "physical role limitation", "emotional role limitation", "vitality", "mental health", "social function" and "general health" became impaired, d-so did the sleep quality. It was reported in many studies in the literature that as sleep quality deteriorated, life quality became also impaired (16,(34)(35)(36). In our result, no significant relations were detected between thyroid functions and any of the subdimensions of life quality.…”

Section: Discussioncontrasting

confidence: 69%

“…In a study investigating the life and sleep quality scores of pregnant women with high risks (pregnant women diagnosed with diabetes and hypertension), it was determined that sleep and life quality were impaired (35). In a study that was conducted on life quality and problem-solving skills of diabetes patients, no relations were detected between blood sugar and hemoglobin A1c levels and life quality.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Endocrinological Parameters on Sleep Quality, Life Quality, Depression and Anxiety Levels in Pregnancy

Özsoy

Doğru

Delibaş

et al. 2020

Clinical and Experimental Health Sciences

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Objectives: Examining the relation between sleep quality, quality of life, depression and anxiety levels with some endocrinological parameters in pregnancy. Methods:The oral glucose loading test and thyroid function test results of the pregnant women who were in the 24-29th weeks of pregnancy were used in the study. Non-pregnant women, who were matched with the study group in terms of sociodemographic data, were also included in the study as the healthy control group. All participant completed a standardized sociodemographic data collection form and the following scales; Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburg Sleep Quality Scale (PDCA), Quality of Life Scale (SF-36).Results: No significant differences were detected between the sociodemographic data of the participants except for the educational status and living area. As a result, statistically significant differences were detected between the "sleep latency" (p=0.016), "usual sleep activity" (p=0.004), "sleep disorder" (p=0.000) subcomponents compared to the control group. For SF-36, on the other hand, the results of the pregnant group in "physical function" (p=0.000), "physical role limitation" (p=0.002) and "pain" (p=0.000) sub-dimensions were worse than the control group. The Thyroid Stimulating Hormone (TSH) value was positively correlated with "sleep time" (r=0.233); the "fasting blood glucose" was positively correlated with "pain" sub-dimensions (r=0.497); and the "physical function" sub-dimension was negatively correlated (r=-0.192). Conclusion:Our data suggest that the depression and anxiety scores of the pregnant women were high, and life and sleep quality was impaired in certain sub-dimensions.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

The Effect of Endocrinological Parameters on Sleep Quality, Life Quality, Depression and Anxiety Levels in Pregnancy

Özsoy

Doğru

Delibaş

et al. 2020

Clinical and Experimental Health Sciences

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“…Clinical research has shown that high‐risk pregnant women (those with gestational diabetes and hypertension) also suffer from poor quality sleep . Ten genome‐wide association scans involving 36,610 Europeans showed that variants in the gene encoding the melatonin (Mel) receptor 1b were associated with disruption of normal glucose homeostasis .…”

Section: Introductionmentioning

confidence: 99%

Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia

Zhang

Liu

et al. 2019

Stem Cells

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Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one of the most devastating complications of gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective actions in various stresses. However, the role of autophagy and the involvement of Mel in NSCs in hyperglycemia (HG) have not yet been fully established. Here, we found that HG increased autophagy and autophagic flux of NSCs as evidenced by increasing LC3B II/I ratio, Beclin-1 expression, and autophagosomes. Moreover, Mel enhanced NSCs proliferation and self-renewal in HG with decreasing autophagy and activated mTOR signaling. Consistently, inhibition of autophagy by 3-Methyladenine (3-Ma) could assist Mel effects above, and induction of autophagy by Rapamycin (Rapa) could diminish Mel effects. Remarkably, HG induced premature differentiation of NSCs into neurons (Map2 positive cells) and astrocytes (GFAP positive cells). Furthermore, Mel diminished HG-induced premature differentiation and assisted NSCs in HG differentiation as that in normal condition. Coincidentally, inhibiting of NSCs autophagy by 3-Ma assisted Mel to modulate differentiation. However, increasing NSCs autophagy by Rapa disturbed the Mel effects and retarded NSCs differentiation. These findings suggested that Mel supplementation could contribute to mimicking normal NSCs proliferation and differentiation in fetal central nervous system by inhibiting autophagy in the context of gestational diabetes. STEM CELLS 2019;37:504-515 SIGNIFICANCE STATEMENTNeural stem cells play important roles in fetal neurodevelopment. The incidences of gestational diabetes are rising in the world and prevention of fetal neuropathy in gestational diabetes mellitus (GDM) needs to be deeply explored. In addition, autophagy of NSCs in HG is still unclear. Here, it is reported that HG inhibits proliferation and induces premature differentiation of NSCs by promoting autophagy and autophagic flux. The naturally occurring hormone melatonin (Mel) antagonized HG-mediated effects and maintained normal proliferation and differentiation in NSCs by modulating autophagy, which protected NSCs mainly by downregulating Beclin-1 and up modulating mTORC1 signaling. This work indicates that Mel could be used as a potential drug to aid in fetal central nervous system (CNS) development in GDM patients.

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“…A score of 5 and above indicates poor sleep quality. The reliability, sensitivity and specificity of the questionnaire were equal to 0.83, 89.6% and 86.5%, respectively (18) which have been used in various studies in Iran (15,19).…”

Section: Data Collection Toolmentioning

confidence: 99%

The Relationship Between Leg Muscle Cramps and Sleep Quality in Pregnant Women Visited the Health Centers in Tabriz

Mansouri¹,

Bahrami-Vazir

Mohammad‐Alizadeh‐Charandabi

et al. 2019

Shiraz E-Med J

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Background: Leg muscle cramps (LMCs) and sleep disorders are a common problem during pregnancy, and may be correlated. Objectives: The aims of this study were to determine the features of LMCs and sleep quality as well as their association in the third trimester of pregnancy. Methods: This cross-sectional study was conducted on 439 pregnant women referred to health centers/posts of Tabriz, Iran, in 2014. The participants were selected through double stage cluster sampling method. Data were collected by using a socio-demographic questionnaire, Pittsburgh sleep quality index and leg muscle cramp characteristics questionnaire. Chi-square, Independent t, Pearson and Spearman correlation and Mann-Whitney U tests were used for data analysis. Results: The mean ± SD total sleep quality score was 8.8 ± 3.9, within a possible score range of 0 to 21. About 84% of the women had sleep quality disturbances. LMCs were observed in more than half of the participants and there was a statistically significant correlation between the occurrence of LMCs and total sleep quality score (P = 0.001) and sub domains of sleep disturbances and daytime dysfunction (P < 0.001). There was also a significant relationship between occurrence of sleep quality disturbances and occurrence of LMCs (P = 0.006). Conclusions: The present study showed that leg muscle cramps and sleep disorder are common during pregnancy and sleep quality disturbances are correlated with occurrence of leg muscle cramps. Prevention and treatment actions should be considered in the prenatal care.

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Sleep quality and its relationship with quality of life among high-risk pregnant women (gestational diabetes and hypertension)

Abstract: The findings of current research show that sleep quality is low among high-risk pregnant women and quality of life is medium. So, it is necessary that required training is given by health cares for improving sleep quality and quality of life to mothers.

Cited by 30 publications

References 15 publications

The Effect of Endocrinological Parameters on Sleep Quality, Life Quality, Depression and Anxiety Levels in Pregnancy

The Effect of Endocrinological Parameters on Sleep Quality, Life Quality, Depression and Anxiety Levels in Pregnancy

Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia

The Relationship Between Leg Muscle Cramps and Sleep Quality in Pregnant Women Visited the Health Centers in Tabriz

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