Sleep quality in patients with Behçet's disease

Yazmalar, Levent; Batmaz, İbrahim; Sarıyıldız, Mustafa Akif; Yıldız, Mehmet; Uçmak, Derya; Türkçü, Fatih Mehmet; Akdeniz, Dicle; Sula, Bilal; Çevik, Remzi

doi:10.1111/1756-185x.12459

Cited by 22 publications

(27 citation statements)

References 27 publications

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“…[10] In addition, studies focusing on the effect of BD on sleep disturbance and QoL found that patients with BD have reduced sleep quality and QoL. [11][12][13] The findings from the present study are consistent with previous studies for the evolution of depression, anxiety, and QoL in the patients with BD. A significant role of emotional dysfunction was also shown in the course of rheumatic diseases such as BD.…”

Section: Discussionsupporting

confidence: 90%

The frequency and effect of fibromyalgia in patients with Behçet’s disease

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et al. 2017

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the scores of depression, anxiety, sleep and quality of life (QoL), to identify the prevalence of fibromyalgia (FM) in Behçet's disease (BD), and to evaluate whether there is a difference between BD patients with and without FM in these scores. Patients and methods: Between March 2008 and January 2009, 97 patients with BD and 95 age-and sex-matched healthy controls were included in the study. The patients with BD were divided into two groups according to the presence or absence of FM. All participants were evaluated by the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), and Medical Outcomes Study Short Form-36 (SF-36). Results: Compared to the controls, FM prevalence was higher (19.6% vs 3.2%) with increased BDI and BAI scores, while the subscores of SF-36 including physical function, physical role, pain, general health, social function, and emotional role decreased in BD patients (for all p<0.001). All BD patients with FM were females (n=19), while only 46% of BD patients without FM were females (n=36) (p<0.001). In BD patients with FM, compared to female BD patients without FM, the mean age (p=0.017), disease duration (p=0.028), and BDI scores (p=0.017) were significantly higher, while the PSQI scores (p=0.001) and SF-36 subscores, except general health (p=0.114), were significantly lower (for all p<0.05). Conclusion: Our study results suggest that patients with BD have an increased severity of depression and anxiety, higher frequency of FM, and worsened QoL than healthy individuals. In addition, the presence of FM seems to be related with female sex, longer disease duration, older age, depression, sleep disturbance, and poor QoL in BD patients.

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Section: Discussionsupporting

confidence: 90%

The frequency and effect of fibromyalgia in patients with Behçet’s disease

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Alpaycı

et al. 2017

Turk J Phys Med Rehab

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“…The results of the study showed that BD patients had increased anxiety, depression and MAF scores compared to the healthy control group. Ertam et al showed that in chronic diseases due to pain, depression and sleep disorders were also present and all of these contributed to a reduced QoL . Yazmalar et al investigated the frequency of depression in BD patients using the HADS, as in the current study .…”

Section: Discussionmentioning

confidence: 79%

An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

et al. 2018

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Objectives Behçet's disease (BD) is a type of systemic vasculitis and inflammatory disease of unknown etiology, which is associated with fatigue and lower quality of life (QoL). The aim of this study was to assess the relationship between Behçet's Disease Current Activity Form (BDCAF) and Behçet's Disease Quality of Life (BDQoL), depression, anxiety and fatigue in Behçet's disease. Methods We conducted a cross‐sectional study of 155 BD patients and 107 healthy subjects in a single center over a 1 year period. All participants completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, and the Hospital Anxiety and Depression (HADS) scale. Disease activity in the BD patients was assessed using the BDCAF, and the physician's global assessment (PGA). BD patients also completed the BDQoL questionnaire. Results There was no significant difference in age and gender between the groups. BD patients had significantly higher HADS‐anxiety (HADS‐A), HADS‐depression (HADS‐D) and MAF scores than the healthy control group (P < 0.05). BD patients with active disease had significantly higher MAF and HADS‐A scores compared to inactive BD patients (P < 0.05). MAF scores showed positive correlations with HADS‐A, HADS‐D, BDCAF and BDQoL. Conclusions Fatigue and anxiety are common in clinically active BD patients compared with healthy control subjects and inactive BD patients.

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“…Behçet's disease (BD) is a systemic inflammatory disorder characterized by recurrent oral and genital ulcers, uveitis, and skin lesions such as erythema nodosum and pustules . Although our understanding of the causes and pathogenesis of BD remains incomplete, the features of BD as an inflammatory multi‐system disease with spontaneous remissions and relapses are similar to those of other autoimmune diseases .…”

Section: Introductionmentioning

confidence: 99%

Serum GDF‐15 level in Behçet's disease: relationships between disease activity and clinical parameters

et al. 2016

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Growth differentiation factor-15 (GDF-15), a member of the transforming growth factor-β superfamily of cytokines, plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate serum GDF-15 levels and their relationships with disease-related variables in patients with Behçet's disease (BD). Forty-six patients diagnosed with BD and 30 demographically matched healthy control subjects participated in the study. GDF-15 levels were measured in blood samples from patients and controls. The Behçet's Disease Current Activity Form (BDCAF) was used to evaluate the disease activity of BD. There were no significant differences between the two groups in C-reactive protein (CRP) level, mean erythrocyte sedimentation rate (ESR), age, body mass index, and mean GDF-15 levels (P > 0.05). Serum GDF-15 levels were positively correlated with findings for peripheral arthritis and CRP, and with BDCAF erythema nodosum, BDCAF arthralgia, and BDCAF arthritis scores. Patients with BD were divided into two groups according to the presence of peripheral arthritis; nine subjects (20%) were positive for peripheral arthritis. Serum ESR, CRP, white blood cell counts, and GDF-15 levels were significantly higher in the group that was positive for peripheral arthritis (P < 0.05). GDF-15 may play a role in the progression and pathway of Behçet's joint involvement and erythema nodosum that is independent of classic inflammatory response measures.

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Sleep quality in patients with Behçet's disease

Abstract: Sleep quality is disturbed in patients with BD. The lower quality of sleep is greatly associated with anxiety, depression, QoL, genital ulcers and arthritis.

Cited by 22 publications

References 27 publications

The frequency and effect of fibromyalgia in patients with Behçet’s disease

The frequency and effect of fibromyalgia in patients with Behçet’s disease

An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

Serum GDF‐15 level in Behçet's disease: relationships between disease activity and clinical parameters

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