Slimpid May Boost Plasma IGF-1 Level and Improve the Quality of Life in Patients with Risk of Developing Metabolic Syndrome

Chui, Shiu Hon; Chow, Fung Chun; Chan, Kelvin; Fu, Samuel; Szeto, Yim Tong Savio

doi:10.2202/1553-3840.1090

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Results of the present study illustrated that a metabolomics-based analysis of the effects of a multi-component preparation can be used to study potential target processes or novel ingredients. Preparations having their origin in other healthcare systems such as CM have been shown to provide interesting starting points [36] – [42] . In a previous study it was found that SUB885C improved insulin sensitivity compared to control in pre-diabetic ApoE*3Leiden mice fed with a high fat diet for 10 weeks [7] .…”

Section: Discussionmentioning

confidence: 99%

Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice

Wei¹,

Wang³

et al. 2012

PLoS ONE

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BackgroundCauses and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses.Methodology/Principal FindingsApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (−49%, p<0.001), CETP levels (−31%, p<0.001), CETP activity (−74%, p<0.001) and increased HDL-C (39%, p<0.05). It influenced lipidomics classes of cholesterol esters and triglycerides the most. Rimonabant induced a weight loss (−9%, p<0.05), but only a moderate improvement of lipid profiles. In vitro, SUB885C extract caused adipolysis stimulation and adipogenesis inhibition in 3T3-L1 cells.ConclusionsSUB885C, a multi-components preparation, is able to produce anti-atherogenic changes in lipids of the ApoE*3Leiden.CETP mice, which are comparable to those obtained with compounds belonging to known drugs (e.g. rimonabant, atorvastatin, niacin). This study successfully illustrated the power of lipidomics in unraveling intervention effects and to help finding new targets or ingredients for lifestyle-related metabolic abnormality.

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Section: Discussionmentioning

confidence: 99%

Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice

Wei¹,

Wang³

et al. 2012

PLoS ONE

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“…The spray‐dried extract containing active ingredients of the medicine was machine‐ground to fine powder form. When used for the preparation of a prescribed decoction, dry powders of individual medicines were mixed in appropriate ratios calculated from the concentration factor and the weight of the raw medicines required for the prescription (Chui et al ., ). Powder concentrates of the chosen CM were obtained from one distributor while the raw medicines were from a different distributor.…”

Section: Methodsmentioning

confidence: 97%

Study of Heavy Metal Poisoning in Frequent Users of Chinese Medicines in Hong Kong and Macau

Chui

Wong²,

Chio

et al. 2012

Phytotherapy Research

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This study is a direct assessment of blood heavy metal concentrations of frequent users of Chinese medicines (CM), who had been taking prescribed CM at least 6 days per week for not less than 3 months, to determine whether their intake of CM could cause an increased load of toxic heavy metals in the body. From November 2009 to June 2010, 85 subjects were recruited with informed consent, and their blood samples were collected for measurement of arsenic, cadmium, lead and mercury concentrations. Results showed that blood concentrations of four heavy metals of nearly all 85 subjects were within reference ranges. Only one subject who had consumed plentiful seafood was found to have transiently increased blood arsenic concentration (29% higher than the upper limit of the reference range). However, after refraining from eating seafood for 1 month, his blood arsenic concentration returned to normal. Eighty commonly prescribed CM in both raw medicine and powder concentrate supplied by local distributors were also tested for the four heavy metals. Twelve out of the 80 raw medicines were found to contain one or more of the heavy metals that exceeded the respective maximum permitted content. Cadmium was most frequently found in the contaminated samples. None of the powder concentrates had heavy metal content exceeding their respective maximum permitted level.

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“…For example, Liu et al [31] considered that the Chinese Quality of Life (ChQOL) instrument, a domestic general assessment instrument, reflected the characteristics of Chinese medicine and Chinese culture. Those characteristics specified by the Wong W et al [3] ChQOL instrument (Liu FB et Chui SH et al [4] ChQOL instrument (Liu FB et Liu WH et al [5] ChQOL instrument Wang HY et al [6] ChQOL instrument (Liu FB et Zhang YJ et al [10] Fatigue self-rating scale ( Ji ZY et al [11] Fatigue self-rating scale (Wang TF et al)…”

Section: Application In Basic and Theoretical Researchmentioning

confidence: 99%

Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine

Liu

Hou

Yang

et al. 2013

Journal of Integrative Medicine

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OBJECTIVE:To evaluate the application of health assessment instruments in Chinese medicine. METHODS: According to a pre-defined search strategy, a comprehensive literature search for all articles published in China National Knowledge Infrastructure databases was conducted. The resulting articles that met the defined inclusion and exclusion criteria were used for analysis. RESULTS: A total of 97 instruments for health outcome assessment in Chinese medicine have been used in fundamental and theoretical research, and 14 of these were also used in 29 clinical trials that were randomized controlled trials, or descriptive or cross-sectional studies. In 2 152 Chinese medicine-based studies that used instruments in their methodology, more than 150 questionnaires were identified. Among the identified questionnaires, 51 were used in more than 10 articles (0.5%). Most of these instruments were developed in Western countries and few studies (4%) used the instrument as the primary evidence for their conclusions. CONCLUSION: Usage of instruments for health outcome assessment in Chinese medicine is increasing rapidly; however, current limitations include selection rationale, result interpretation and standardization, which must be addressed accordingly. KEYWORDS: treatment outcome; health-related quality of life; patient-reported outcome; personal satisfaction; questionnaires; instrumentation; medicine, Chinese traditional; outcome assessment (health care) DOI: 10.3736/jintegrmed2013023 Liu FB, Hou ZK, Yang YY, Li PW, Li QW, Xie N, Li JW, Zeng XJ. Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine.

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Slimpid May Boost Plasma IGF-1 Level and Improve the Quality of Life in Patients with Risk of Developing Metabolic Syndrome

Cited by 5 publications

References 17 publications

Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice

Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice

Study of Heavy Metal Poisoning in Frequent Users of Chinese Medicines in Hong Kong and Macau

Literature review and analysis of the application of health outcome assessment instruments in Chinese medicine

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