Slow Down and Seize: Seizures Triggered by Slow Wave Oscillations in a GABAergic Model of Dravet Syndrome

Buchanan, Gordon F.

doi:10.1177/15357597231174111

Cited by 1 publication

(1 citation statement)

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“…Dendritic GABAergic inhibitory dysfunction has been connected to gamma band activity observed in EEG seizure recordings [ 52 , 53 , 54 ]. However, elevating GABA concentration by giving the GABA antagonist vigabatrin to both rats and people has enhanced resting delta power [ 55 , 56 ], demonstrating that the U-shaped spectral profile in ASD cannot be fully explained by a simple decrease in GABA.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Retained Primitive Reflexes and Hemispheric Connectivity in Autism Spectrum Disorders

Melillo,

Leisman,

Machado

et al. 2023

Brain Sciences

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Background: Autism Spectrum Disorder (ASD) can be identified by a general tendency toward a reduction in the expression of low-band, widely dispersed integrative activities, which is made up for by an increase in localized, high-frequency, regionally dispersed activity. The study assessed ASD children and adults all possessing retained primitive reflexes (RPRs) compared with a control group that did not attempt to reduce or remove those RPRs and then examined the effects on qEEG and brain network connectivity. Methods: Analysis of qEEG spectral and functional connectivity was performed, to identify associations with the presence or absence of retained primitive reflexes (RPRs), before and after an intervention based on TENS unilateral stimulation. Results: The results point to abnormal lateralization in ASD, including long-range underconnectivity, a greater left-over-right qEEG functional connectivity ratio, and short-range overconnectivity in ASD. Conclusion:. Clinical improvement and the absence of RPRs may be linked to variations in qEEG frequency bands and more optimized brain networks, resulting in more developmentally appropriate long-range connectivity links, primarily in the right hemisphere.

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