Slow Evoked Cortical Responses to Linear Frequency Ramps of a Continuous Pure Tone

Arlinger, Stig; Jerlvall, Lars; Ahrén, T.; Holmgren, Eddy

doi:10.1111/j.1748-1716.1976.tb10330.x

Cited by 35 publications

(25 citation statements)

References 18 publications

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“…Potentials associated with oscillation between the notes A and B were consistently present at the slowest rate of 4 4 Ž 8 changesrs negativity peaking about 150 ms after each . change but of very low amplitude or absent at the two Ž .…”

Section: Methodsmentioning

confidence: 94%

“…Responses of eight subjects were obtained to connected tones oscillating between A and B before 4 4 coming to rest on B . The identical sequence was pre- 4 sented at three different speeds, such that the rate of oscillation was 8, 12 or 16 changesrs with durations of 5, 3.3 or 2.5 s, respectively, and the duration of the steady note was 0.5, 0.33 or 0.25 s The triggers were delivered to the averager 15 ms before the 3rd, 7th, 11th, 15th and 19th Ž repetitions of the note A these responses being averaged 4 . together and at the end of the oscillatory period, 15 ms before the next presentation of A should have occurred.…”

Section: Methodsmentioning

confidence: 99%

“…together and at the end of the oscillatory period, 15 ms before the next presentation of A should have occurred. 4 Responses were averaged to 220 oscillatory changes and 45 'non-events' at the end of the sequence, and three repetitions performed for each condition.…”

Section: Methodsmentioning

confidence: 99%

“…Responses of eight subjects were recorded to the notes A and B 100 ms in duration 4 4 Ž . including riserfall time with silent gaps of 250 ms The deviant B tones occurred regularly after every five pre- 4 sentations of the standard A . In each run the responses to 4 ( )Ž 100 deviants and 300 standards the three preceding each .…”

Section: Methodsmentioning

confidence: 99%

“…In the MMN study, responses to the standard A tones 4 presented five times in every cycle consisted of a P1 at 60-70 ms followed by a shallow N1 and P2. Responses to the deviant B presented once in every cycle consisted of 4 a similar P1 and P2 but a larger N1.…”

Section: Methodsmentioning

confidence: 99%

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Cortical processing of complex tone stimuli: mismatch negativity at the end of a period of rapid pitch modulation

Pato

Jones

1999

Cognitive Brain Research

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In this study, synthesised instrumental tones were used to examine human auditory cortical processes engaged at the end of a period of w rapid pitch modulation. It was previously S.J. Jones, O. Longe, M. Vaz Pato, Auditory evoked potentials to abrupt pitch and timbre Ž . x change of complex tones: electrophysiological evidence of 'streaming'?, Electroencephalogr. Clin. Neurophysiol., 108 1998 131-142 suggested that the 'change-N1' produced by infrequent changes in pitch or timbre of a continuous complex tone represents the activity of a neuronal population topographically distinct from that responsible for the 'onset-N1' at the beginning of the tone. In the present study a Ž . superficially similar negativity was produced when the tone came to rest on a steady pitch after a period of rapid 8-16 changesrs modulation; its scalp maximum was anterior to that of the two previously identified potentials but similar to that of the mismatch negativity elicited by discontinuous tones. By varying the modulation rate the latency was shown to be relatively constant with respect to the time the next pitch change was expected but failed to occur. The largest responses averaging c. 7 mV were evoked at the end of modulation sequences which were both rhythmic and repetitive, but a potential was still produced when there was no rhythmic pattern or repetition of individual notes. This response to non-occurrence of an expected but not necessarily specified change implies an automatic process for comparing the incoming sound with an extrapolated template of the preceding pattern in which timing as well as pitch information is accurately represented. We suggest this technique offers a robust method for eliciting the mismatch negativity, which may extend the opportunities for electrophysiological investigation of higher auditory processes. q

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Section: Methodsmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Cortical processing of complex tone stimuli: mismatch negativity at the end of a period of rapid pitch modulation

Pato

Jones

1999

Cognitive Brain Research

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Tone-Evoked Acoustic Change Complex (ACC) Recorded in a Sedated Animal Model

Presacco

Middlebrooks

2018

JARO

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The acoustic change complex (ACC) is a scalp-recorded cortical evoked potential complex generated in response to changes (e.g., frequency, amplitude) in an auditory stimulus. The ACC has been well studied in humans, but to our knowledge, no animal model has been evaluated. In particular, it was not known whether the ACC could be recorded under the conditions of sedation that likely would be necessary for recordings from animals. For that reason, we tested the feasibility of recording ACC from sedated cats in response to changes of frequency and amplitude of pure-tone stimuli. Cats were sedated with ketamine and acepromazine, and subdermal needle electrodes were used to record electroencephalographic (EEG) activity. Tones were presented from a small loudspeaker located near the right ear. Continuous tones alternated at 500-ms intervals between two frequencies or two levels. Neurometric functions were created by recording neural response amplitudes while systematically varying the magnitude of steps in frequency centered in octave frequency around 2, 4, 8, and 16 kHz, all at 75 dB SPL, or in decibel level around 75 dB SPL tested at 4 and 8 kHz. The ACC could be recorded readily under this ketamine/azepromazine sedation. In contrast, ACC could not be recorded reliably under any level of isoflurane anesthesia that was tested. The minimum frequency (expressed as Weber fractions (df/f)) or level steps (expressed in dB) needed to elicit ACC fell in the range of previous thresholds reported in animal psychophysical tests of discrimination. The success in recording ACC in sedated animals suggests that the ACC will be a useful tool for evaluation of other aspects of auditory acuity in normal hearing and, presumably, in electrical cochlear stimulation, especially for novel stimulation modes that are not yet feasible in humans.

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Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction

Vonck

Lammers

Waals

et al. 2019

JARO

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Recent literature on cortical auditory evoked potentials has focused on correlations with hearing performance with the aim to develop an objective clinical tool. However, cortical responses depend on the type of stimulus and choice of stimulus parameters. This study investigates cortical auditory evoked potentials to sound changes, so-called acoustic change complexes (ACC), and the effects of varying three stimulus parameters. In twelve normal-hearing subjects, ACC waveforms were evoked by presenting frequency changes with varying magnitude, rate, and direction. The N1 amplitude and latency were strongly affected by magnitude, which is known from the literature. Importantly, both of these N1 variables were also significantly affected by both rate and direction of the frequency change. Larger and earlier N1 peaks were evoked by increasing the magnitude and rate of the frequency change and with downward rather than upward direction of the frequency change. The P2 amplitude increased with magnitude and depended, to a lesser extent, on rate of the frequency change while direction had no effect on this peak. The N1–P2 interval was not affected by any of the stimulus parameters. In conclusion, the ACC is most strongly affected by magnitude and also substantially by rate and direction of the change. These stimulus dependencies should be considered in choosing stimuli for ACCs as objective clinical measure of hearing performance.

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Slow Evoked Cortical Responses to Linear Frequency Ramps of a Continuous Pure Tone

Cited by 35 publications

References 18 publications

Cortical processing of complex tone stimuli: mismatch negativity at the end of a period of rapid pitch modulation

Cortical processing of complex tone stimuli: mismatch negativity at the end of a period of rapid pitch modulation

Tone-Evoked Acoustic Change Complex (ACC) Recorded in a Sedated Animal Model

Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction

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