Slow progression and benign course of a primary malign melanoma of a lumbar nerve root

Ganiüsmen, Ozan; Özer, Füsun Demirçivi; Mete, Mesut; Özdemir, Nail; Bayol, Ümit

doi:10.1016/j.clineuro.2011.09.012

Cited by 10 publications

(16 citation statements)

References 5 publications

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“…3,8,17,21,22 Of the total 27 cases, only 2 cases had recurrence records. 14,17 The survival time of PSM was between 2 weeks and 17 years (median time: Abbreviations: Ch, chemotherapy; da, days; Enh, enhancement; F, female; Hyper-, hyperintense; hypo-, hypointense; M, male; mo, months; NS, not stated; Rad, radiotherapy; wk, weeks; yr, years.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of tumors were solitary and only one patient with multiple foci was reported. 4 A few tumors originated from the nerve roots or had spinal nerve root involvement, [5][6][7][8][9] which led to the enlargement of the intervertebral foramen, and even spread outside the intervertebral foramen 2,10 or destruction of the vertebral pedicles. 8,11 Signs and symptoms of this tumor were nonspecific and dependent on location.…”

Section: Discussionmentioning

confidence: 99%

“…4 A few tumors originated from the nerve roots or had spinal nerve root involvement, [5][6][7][8][9] which led to the enlargement of the intervertebral foramen, and even spread outside the intervertebral foramen 2,10 or destruction of the vertebral pedicles. 8,11 Signs and symptoms of this tumor were nonspecific and dependent on location. 12 However, literature concerning the symptomatic bilateral papilledema induced by increased intracranial pressure 13 or the presence of subarachnoid hemorrhage-like symptoms have been reported, and thus clinicians should be aware of these rare presentations.…”

Section: Discussionmentioning

confidence: 99%

“…3,[5][6][7][9][10][11][17][18][19] Ninety percent of melanomas found in the CNS are metastatic tumors. 8 A thorough physical examination is required to rule out melanoma in other organs outside of the spinal cord, before a diagnosis of PSM can be established. Spinal schwannoma or meningioma lacks the characteristic signals (hyperintensity on T1W and hypointensity on T2W) on MRI examination, even in pigmented schwannoma or meningioma.…”

Section: Discussionmentioning

confidence: 99%

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Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

et al. 2015

Spinal Cord Ser Cases

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STUDY DESIGN: A review of the literature and three case reports. OBJECTIVES: Primary spinal melanoma (PSM) of extramedullary origin is a rare malignant condition with limited current literature in regards to its clinical course, magnetic resonance imaging (MRI) findings, treatment strategies and prognosis. We reported here three cases of PSM of extramedullary origin. SETTING: China, Guangzhou. METHODS: We report three cases of PSM of extramedullary origin. The clinical and radiological findings of these cases were retrospectively analyzed. RESULTS: The three cases were all of males aged 39, 47 and 76 years, respectively. The duration of their symptoms was 3 weeks, 2 months and 11 months respectively. The extramedullary tumors were all well-defined solitary tumors and were located at C4-5, L2-3 and T9-10, respectively. In one case, involvement of the intervertebral foramen was found. Preoperative MRI showed hyperintense T1W signals and hypointense T2W signals in all three cases and all tumors were clinically misdiagnosed as schwannomas. The patients received total or subtotal resection surgery without radiotherapy or chemotherapy. Patients were alive at 18 months, 27 months and 36 months postoperative follow-up, respectively. CONCLUSION: PSM of extramedullary origin is a rare malignant tumor that shows characteristic findings on MRI. Surgical resection is the preferred treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

et al. 2015

Spinal Cord Ser Cases

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“…Primary malignant melanoma of the central nervous system (CNS) accounts for 1% of all cases of melanoma. Primary spinal melanoma is particularly rare and may be intra- or extradural, or may possess intra- and extramural components (2). Spinal melanoma is primarily found in the middle or lower thoracic spine.…”

Section: Introductionmentioning

confidence: 99%

Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review

Zhang

She

et al. 2014

Oncology Letters

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Primary spinal melanoma is a rare lesion, which occurs throughout the cranial and spinal regions, however, is primarily observed in the middle or lower thoracic spine. The clinical features of primary spinal melanoma are complex and unspecific, resulting in a high misdiagnosis rate. In the present case report, a rare case of spinal melanoma exhibiting the dural tail sign and mimicking spinal meningioma is reported. The initial diagnosis, using magnetic resonance imaging (MRI), was unclear. Thus, melanin-containing tumors and spinal meningioma should have been considered in the differential diagnosis. The tumor was completely resected using a standard posterior midline approach, which was followed by chemotherapy. Subsequent to the surgery, the patient was discharged with improved motor capacity and a follow-up MRI scan showed no recurrence after six months. The present study demonstrates that it is critical for neurosurgeons to focus on increasing the accuracy of initial diagnoses in order to make informed decisions regarding the requirement for surgical resection. The present case report presents the clinical, radiological and pathological features of primary extramedullary spinal melanoma mimicking spinal meningioma to emphasize the importance of early identification and diagnosis.

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Primary Spinal Melanoma: Case Report and Systematic Review

Haberfellner

Elbaroody

Alkhamees

et al. 2021

Clinical Neurology and Neurosurgery

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Slow progression and benign course of a primary malign melanoma of a lumbar nerve root

Cited by 10 publications

References 5 publications

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

Primary spinal melanoma of extramedullary origin: a report of three cases and systematic review of the literature

Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review

Primary Spinal Melanoma: Case Report and Systematic Review

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