Slow-stimulated Multifocal ERG in High- and Normal-tension Glaucoma

Palmowski-Wolfe, Anja; Allgayer, Reiner; Vernaleken, Bernhild; Schötzau, Andy; Ruprecht, Klaus W.

doi:10.1007/s10633-006-0007-9

Cited by 18 publications

(16 citation statements)

References 20 publications

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“…At a stimulus base interval of~54 ms there is no overlap between the induced component and the m sequence response. Under these conditions, oscillatory potentials become apparent in the induced component [21] and the sensitivity to detect NTG increases to about 85% [22].…”

Section: Introductionmentioning

confidence: 99%

The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma

et al. 2006

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Section: Introductionmentioning

confidence: 99%

The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma

et al. 2006

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“…Recently a special slow mfERG stimulus sequence has been suggested to be sensitive in OAG [14,15]. With an increase in the stimulus base interval to 53.3 ms or more, there is no more overlap between the induced component and the m-sequence response.…”

Section: Introductionmentioning

confidence: 99%

“…These mfOPs, show a marked naso-temporal asymmetry [16,17] which may be attributed to the misalignment and partial cancellation of the RC with the ONHC in the nasal retina and their relative alignment and enhancement in the temporal retina [16]. Under these conditions the sensitivity to detect normal tension OAG increases to about 85% [15].…”

Section: Introductionmentioning

confidence: 99%

Influence of Dopamine Deficiency in Early Parkinson’s Disease on the Slow Stimulation Multifocal-ERG

et al. 2006

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In contrast to our previous findings in NTG, there was a consistent presence of three OPs. Under the stimulus conditions applied, we did not find an influence of dopaminergic amacrine cells on the mfERG in our patients with moderate stages of Parkinsion's. The difficulties in obtaining an adequate signal-to noise ratio due to e.g. muscle artifacts even in Parkinson patients of moderate disease stages render a success of mfERG recording in patients with more advanced stages unlikely. The question of the influence of dopaminergic amacrine cells on the mfERG could possibly be addressed using MPDT in animal research.

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“…For the full-field S-cone ERG, the PhNR has been reported to be able to differentiate patients with HTG but not with NTG from a control group [34]. For the mfERG with special stimulation parameters, small differences in the distribution and the amount of retinal dysfunction have been seen when HTG patients were compared with NTG patients [21,35,36].…”

Section: In Itmentioning

confidence: 99%

MfERG responses to long-duration white stimuli in glaucoma patients

Todorova

Palmowski-Wolfe

2011

Doc Ophthalmol

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The intent of our study was to evaluate whether the response to a long-duration white stimulus in the multifocal electroretinogram (mfERG) is sufficiently sensitive to detect early retinal dysfunction in glaucoma. On-off mfERGs were recorded from 15 NTG and 15 HTG patients and compared with 14 control subjects. Recording parameters were the following: LED stimulus screen (RETIscan™), 100-ms stimulus duration, 200-ms stimulus interval, 11-min total recording time, stimulus matrix of 61 elements, frame rate: 70 Hz, Lmax: 180 cd/m(2), Lmin: 0 cd/m(2), and filter setting: 1-200 Hz. The second negative response following stimulus onset (N2-on), as well as following stimulus offset (N2-off), was analyzed as an overall response and in quadrants, as well as in 4 small central and four adjoining peripheral areas per quadrant. The latency of the N2-on was significantly delayed in HTG in all response averages tested, while in NTG this was only seen in the overall response and in the small central response averages (P < 0.05). The most sensitive measure in HTG was the latency of the N2-on of the small peripheral response average of the superior temporal quadrant with an area under the ROC curve of 0.881. For NTG, the most representative measure was the latency of the N2-on of the small central response average of the inferior nasal quadrant with an area under the ROC curve of 0.793. Our results showed that in stimulation with long-duration flashes, the second negative response following the on response, representative of the early PhNR, is affected in glaucoma where N2-on showed a latency delay in POAG patients. The latency delay of the N2-on was more prominent for HTG than for NTG.

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Slow-stimulated Multifocal ERG in High- and Normal-tension Glaucoma

Abstract: Under these conditions, the slow-stimulated mfERG can detect glaucomatous dysfunction in NTG (85.0%). The differences observed between NTG and HTG are in support of a different underlying pathomechanism.

Cited by 18 publications

References 20 publications

The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma

The ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma

Influence of Dopamine Deficiency in Early Parkinson’s Disease on the Slow Stimulation Multifocal-ERG

MfERG responses to long-duration white stimuli in glaucoma patients

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