Slower prefrontal metastable dynamics during deliberation predicts error trials in a distance discrimination task

Benozzo, Danilo; Camera, Giancarlo La; Genovesio, Aldo

doi:10.1016/j.celrep.2021.108934

Cited by 20 publications

(24 citation statements)

References 44 publications

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“… 8 More recently, states coding for more abstract stimulus features have been found in a distance-discrimination task in which monkeys had to report which of two stimuli were farther from a central location on a computer screen. 9 In this case, it was found that some states reflect the relative distance of the two stimuli based on their features [e.g., whether they were a blue circle or a red square, see Fig. 3(a) ].…”

Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 97%

“…Since these original works, metastable dynamics has been reported in rat gustatory cortex (GC), 12 in monkey somatosensory, motor, and premotor cortex, 7,15,53 in monkey's area V4, 54 in monkey's orbitofrontal, 14 parietal 13 and dorsolateral prefrontal cortex, 9 in the hippocampus of rats, 55 in the zebrafish 56 and in multiple human brain areas. 6 …”

Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 99%

“…In addition to sensory information, metastable activity has been implicated in changes of behavioral and cognitive states during tasks requiring attention, 54 expectation, 8 decisions, 9,14,15,57 spatial navigation, 55,56 and working memory. 6,15 …”

Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 99%

“… 8 Metastable states have been found to code for more abstract concepts such as the relative distance of two target stimuli based on stimulus features. 9 In addition to the meaning of coding states, it is their organization in sequences that promises the largest benefit in terms of coding. In one example, when states coding for different stimulus features 10–12 or different decisions 13,14 occur in the same sequence, they allow the possibility to code for all options relevant to a particular task, even while the subject is being presented with a subset of them.…”

Section: Introductionmentioning

confidence: 99%

“… 8 On the other hand, monkeys performing a distance-discrimination task tend to make errors when state sequences stretch out in time, i.e., when the metastable dynamics slow down. 9 …”

Section: Introductionmentioning

confidence: 99%

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Metastable dynamics of neural circuits and networks

Brinkman

Yan

Maffei

et al. 2022

Applied Physics Reviews

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Cortical neurons emit seemingly erratic trains of action potentials or “spikes,” and neural network dynamics emerge from the coordinated spiking activity within neural circuits. These rich dynamics manifest themselves in a variety of patterns, which emerge spontaneously or in response to incoming activity produced by sensory inputs. In this Review, we focus on neural dynamics that is best understood as a sequence of repeated activations of a number of discrete hidden states. These transiently occupied states are termed “metastable” and have been linked to important sensory and cognitive functions. In the rodent gustatory cortex, for instance, metastable dynamics have been associated with stimulus coding, with states of expectation, and with decision making. In frontal, parietal, and motor areas of macaques, metastable activity has been related to behavioral performance, choice behavior, task difficulty, and attention. In this article, we review the experimental evidence for neural metastable dynamics together with theoretical approaches to the study of metastable activity in neural circuits. These approaches include (i) a theoretical framework based on non-equilibrium statistical physics for network dynamics; (ii) statistical approaches to extract information about metastable states from a variety of neural signals; and (iii) recent neural network approaches, informed by experimental results, to model the emergence of metastable dynamics. By discussing these topics, we aim to provide a cohesive view of how transitions between different states of activity may provide the neural underpinnings for essential functions such as perception, memory, expectation, or decision making, and more generally, how the study of metastable neural activity may advance our understanding of neural circuit function in health and disease.

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Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 97%

Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 99%

Section: Metastable Dynamics In Neural Circuitsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 8 On the other hand, monkeys performing a distance-discrimination task tend to make errors when state sequences stretch out in time, i.e., when the metastable dynamics slow down. 9 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations